Rastavić – Equisetum arvense (Equisetaceae)

Rastavić – Equisetum arvense (Equisetaceae)

BILJNI PREPARATI RASTAVIĆA:

TINKTURA – RASTAVIĆ HSS, hidroetanolni tečni ekstrakt sušene biljke DER 1:5 i
MATIČNA TINKTURA – RASTAVIĆ TM, hidroetanolni tečni ekstrakt sveže biljke DER 1:1

Equiseti tinctura DER 1:5
Equiseti herbae recentis extractum ethanolicum liquidum DER 1:1 (Pharmacopée française 2004)

namenjeni kod kalkuloza i infekcija urinarnog trakta

BILJNI PREPARATI RASTAVIĆA:

TINKTURA – RASTAVIĆ HSS, hidroetanolni tečni ekstrakt sušene biljke DER 1:5 i
MATIČNA TINKTURA – RASTAVIĆ TM, hidroetanolni tečni ekstrakt sveže biljke DER 1:1

Equiseti tinctura DER 1:5
Equiseti herbae recentis extractum ethanolicum liquidum DER 1:1 (Pharmacopée française 2004)

namenjeni kod kalkuloza i infekcija urinarnog trakta

 

ATC: diuretik, antiedemik, antiinflamatik, antioksidans, vulnerar, hepatoprotektor.

 

U skladu sa:

Eu. Ph. 8 (01.07.2015) monografijom: 1825 Equiseti herba
EMA/HMPC/278089/2015, Committee on Herbal Medicinal Products (HMPC) od 2. februara 2016.: Assessment report on Equisetum arvense L., herba

EMA/HMPC/278091/2015, Committee on Herbal Medicinal Products (HMPC) od 07. 07. 2015.: European Union herbal monograph on Equisetum arvense L., herba 

Fr. Ph. 2004 ANSM Equisetum arvense ad praeparationes homoeopathicas 

(PRÊLE DES CHAMPS POUR PRÉPARATIONS HOMÉOPATHIQUES) – Pharmacopée française 2004

 

a) Equisetum arvense, herba (Field horsetail fresh, sterile, aerial part).

Biljni preparati u tečnom obliku (nerazblaženi ili razblaženi) za oralnu i lokalnu upotrebu.

 

Sastav: a) tečni ekstrakt (DER 1:1), ekstrakcioni rastvarač etanol 51% (v/v), HAB 2a;

 

Equisetum arvense L., sadrži 210 istraženih hemijskih jedinjenja koja ispoljavaju 616 aktivnosti (*podaci ažurirani septembra 2020.).

 

Sadržaj:

a) minimalno 0,01% m/m, totalnih flavonoida, izraženih kao izokvercitrozid/ izokvercetin (isoquercitroside) (MF: C21H20O12, MW: 464,3763 g/mol−1),

b) u većoj koncentraciji sadrži kafeinsku kiselinu, karbohidrate, flavonoide, phenolic acid, fosfor, kalijum hlorid, shikimic acid, silicijum (najviše posle Oryza sativa), silicijumovu kiselinu (najviše posle Agrimonia eupatoria),

c) više od svih biljaka sadrži equisetoninisoquercitroside, niacincistationin (cystathionine), Di-E-caffeoyl-meso-tartaric acid, protogenkwanin, rhodoxanthin,

d) herba sadrži vode do 78,6 %.

 

Indikacije: biljni preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva. Upotreba kod urogenitalnih, gastrointestinalnih, respiratornih i kožnih  tegoba.

 

Dr. Džems Djuk (Dr. James Duke) u Handbook of Medicinal Herbs, 2nd Ed. (2002). CRC Press, navodi sledeće:

– ima jako dejstvo kod: infekcija urinarnog trakta, cistitisa i uretritisa, edema, kalkuloza, peska i kamena bubrega i bešike, inflamacija, respiratornih tegoba, zastoja tečnosti, povreda, opekotina,  …

– delotvoran kod: bakterijskih infekcija, mikobakterijskih, stafilokoknih i streptokoknih, nefritisa, lumbaga, osteoporoze i osteoartroza, polipa, gojaznosti, slabog razvoja kostiju, slabe kose i noktiju, prostatitisa, metroragije, krvarenja u gastrointestinalnom i respiratornom traktu, bolova, imunodepresije, otoka, dermatitisa, … 

– u narodnoj medicini kod: alopecije, artroza, albuminurije, Ca. (abdomena, kostiju, grudi, kolona, intestinuma, bubrega, jezika, usne i usta, jetre, želuca), dijabetesa, dermatoza, dispepsije, disurije, denticije, epistaksije, enureze, fraktura, grčeva, groznice, gasova, gastritisa, gonoreje, gihta, glavobolje, bolesti hematopoeze, hematurije, hemoptizije, holecistitisa, hidropsije, hemoroida, hidropsije, inkontinencije, konjunktivitisa, konstipacije, kalkulusa, reumatizma, rinitisa, nadimanja, proliva, promrzlina, ulceracija, peska i kamena UG trakta, bubrežnih i plućnih tegoba,  tuberkuloze, tumora, rana, kao anodin, antiseptik, adstringent, diuretik, hemopoietik, hemostat, otežanog mokrenja, uganuća, …

– spoljašnja primena kod: dermatitisa, povreda, opekotina, … 

– upotrebljava se kao: jak diuretik i vulnerar, antibakterik, antiedemik, antiinflamatik, antispazmodik, akvaretik, adstringent, hemolitik, hemostatik, imunostimulator, leukocitogenik, tonik, kao biter, karminativ, kuler, dijaforetik, emenagog, nefrotonik, … 

Monografija nemačke E komisije (Commission E Monographs), terapijski vodič za biljne lekove, preporučuje Equisetum aevense za tretman posttraumatskog i statičkog edema, bakterijskih i inflamatornih tegoba, infekcija donjeg urinarnog trakta, peska i kamenaca bubrega i bešike, opekotina, rana, jača kosu, nokte i kosti.

Doziranje i način primene: 2 mL (80 kapi) podeljeno u 2 do 4 doze.

Biljni preparat RASTAVIĆ TM:

pojedinačna doza: 0,5-1 mL,

preporučena dnevna doza (PDD): 2 mL.

Oralna, 15 minuta pre obroka, i lokalna primena.

Upotreba na koži: aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja.

 

Napraviti pauzu posle 4 nedelje neprekidne upotrebe.

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze. 

Kontraindikacije: preosetljivost na aktivne supstance, preosetljivost na biljke porodice (genus Equisetum, family Equisetaceae). 

Potrebna je pažljiva upotreba kod bolesti srca, visokog ili niskog krvnog pritiska, poremećaja u radu bubrega ili jetre, dijabetesa ili edema (oticanja ruku, lica i nogu ) i kod upotrebe proizvoda koji sadrže diuretike,

Čuvanje: na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju,  u dobro zatvorenoj originalnoj ambalaži.

Rok upotrebe: 5 godina, posle prvog otvaranja 6 meseci.  

Pakovanje: 50 mL i 100 mL (1 3/4 fl oz i 3 1/2 fl oz), standardne farmaceutske braon bočice; 250 mL, 500 mL, 1L i 5 L na zahtev.

 

Nutritivne informacije:

RASTAVIĆ HSS I TM:

energetska vrednost u 100 mL: 1172 kJ/ 280 kcal,

u preporučenoj dnevnoj dozi (PDD) 2 mL: 23,45kJ/ 5,6 kcal,

suve materije (DR) više od 0,7% (Fr. Ph.).

 

Bez konzervanasa, proteina, masti i ugljenih hidrata. RASTAVIĆ TM je rukom rađen preparat. 

CENOVNIK

TINKTURA – RASTAVIĆ HSS, hidroetanolni tečni ekstrakt sušene biljke DER 1:5, samo po prethodnom dogovoru. 

MATIČNA TINKTURA – RASTAVIĆ TM, hidroetanolni tečni ekstrakt sveže biljke DER 1:1,

 50 mL –  600 RSD (5 evra), 100 mL – 1200 RSD (10 evra). 

Equisetum arvense (Equisetaceae)

Common names: Horsetail; Field Horsetail

How used Medicinal

Activities: 616 Chemicals w/Activities: 84 All Chemicals: 210

Activity (spisak dejstava po broju bioaktivnih jedinjenja)

antioxidantpesticideCancer-Preventiveantibacterialantitumorantimutagenicantiinflammatoryantiradicularantispasmodic

antiherpetic

diuretic

antiviral

aldose-Reductase-Inhibitor

antiseptic

antileukemic

analgesic

choleretic

hypotensive

hepatoprotective

immunostimulant

antitumor-Promoter

fungicide

antihepatotoxic

cardioprotective

anticancer

antiulcer

Vasodilator

antiHIV

antiaggregant

antiatherosclerotic

hypocholesterolemic

anticataract

antidiabetic

allergenicapoptoticantiallergicantifeedantantihistaminicantiarthriticcytotoxicantiarthriticantinitrosaminic

antiestrogenic

antiasthmatic

antiperoxidant

anxiolytic

Lipoxygenase-Inhibitor

antiarrhythmic

antiproliferant

antiosteoporotic

antitumor (Skin)

antitumor (Lung)

antidepressant

antiaging

ornithine-decarboxylase-inhibitor

Topoisomerase-I-Inhibitor

Immunomodulator

estrogenic

ubiquiot

antihypertensive

immunomodulator

estrogenic

Ubiquiot

antihypertensive

ACE-Inhibitor

TNF-alpha-Inhibitor

antisyndrome-Xantiobesityantialzheimeranantitumor (Colon)candidicideantistresscolorantlaxativehemostat

xanthine-oxidase-inhibitor

antistaphylococcic

antiacne

antipolio

laxative

hemostat

xanthine-oxidase-inhibitor

antistaphylococcic

antiacne

antipolio

antiplaque

Quinone-Reductase-Inducer

insulinogenic

NO-Inhibitor

antiescherichic

neuroprotective

anticolitic

topoisomerase-II-Inhibitor

antiperiodontitic

11B-HSD-Inhibitor

Insectifuge

aromatase-Inhibitor

antiophidic

antiedemic

 Reference:

Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

Williamson, E. M. and Evans, F. J., Potter’s New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.

Economic & Medicinal Plant Research, 5: 198.

List, P.H. and Horhammer, L., Hager’s Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.

Shin*, K.H., Chung, M.S., Chae, Y.J., Yoon, K.Y., Cho, T.S. 1992. A survey for aldose reductase inhibition of herbal medicines. Fitoterapia 64(2): 130, 1993.

Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46.

Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp.

Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X – The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95

Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.

Martindale’s 30th

Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.

Planta Medica, 57: A54, 1991.

Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690.

Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp.

Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY.

Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19.

Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705.

Journal of Medicinal Food 2: 227.1999.

Journal of Medicinal Food 2: 235.1999.

Merck 11th Edition

Chem. & Pharm. Bull. 38: 1772.

Economic & Medicinal Plant Research, 5: 197.

Economic & Medicinal Plant Research, 5: 363.

Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.

Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).

Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.

Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994.

Data  by Dr. Dzejms A. Djuk (Dr. James A. Duke)

 

Horsetail (Equisetum arvense)

Synonyms / Common Names / Related Terms

Bottle brush, cola de caballo, common horsetail, common scouring rush, corncob plant, corn horsetail, Dutch rush, Equisetaceae (family), Equisetum arvense, Equisetum myriochaetumEquisetum ramosissimumEquisetum telmateia, field horsetail, horse willow, hippuric acid, homovanillic acid, horsetail grass, horsetail rush, mokuzoku, mokchok, muzei (E. hymale), paddock pipes, pewterwort, prele, pribes des champs, running clubmoss, Schachtelhalm, scouring rush, Shenjincao, shave grass, toadpipe, Wenjing, Zinnkraut,

Crude drugs derived from Equisetum arvense include Wenjing, Jiejiecao, and Bitoucai.

Combination product examples: Goldenrod-Horsetail® (Herb Pharm Compounds) (liquid extract including 22.5% goldenrod flowering tips, 22.5% corn silk, 22.5% horsetail, 22.5% pipsissewa leaf, and 10% juniper berry); Osteosil® calcium (combination of horsetail and , available in Italy); Eviprostat®.

NoteEquisetum arvense should not be confused with members of the genus Laminaria, bladderwrack, or brown alga, for which „horsetail“ has been used as a synonym.

 

Mechanism of Action

Pharmacology:

  • Constituents: The benzoic acid derivative hippuric acid and the quercetin derivative homovanillic acid are metabolites of Equisestum arvense.5 Crude drugs derived from Equisetum arvense include Wenjing, Jiejiecao, and Bitoucai.6
  • Antioxidant effectsEquisetum telmateia may be a useful source of antioxidants with huge scavenger ability.1
  • Diuretic effects: There is limited research regarding the mechanism of action of horsetail. Horsetail possesses weak diuretic properties, which are believed to be due to equisetonin and flavone glycosides. In one human trial examining patients with a history of nephrolithiasis, an 18-24% statistically significant increase in diuresis was noted in those taking horsetail vs. baseline after 8-12 weeks; these individuals had an increase in glomerular filtration rate (GFR) of 22%.3 Horsetail was also noted to lower urine pH. Renal excretion of uric acid increased as did urine uric acid crystal formation.
  • Hepatoprotective effects: The phenolic petrosin onitin and flavonoid luteolin isolated from Equisetum arvense L. (Equisetaceae) exhibited hepatoprotective activities on tacrine-induced cytotoxicity in human liver cells, displaying EC50 values of 85.8 ± 9.3mcM and 20.2 ± 1.4mcM, respectively.2
  • Steroidal effects: Sterols contained in Equisetum arvense include beta-sitosterol, campesterol, isofucosterol, and trace amounts of cholesterol.4

 

Pharmacodynamics/Kinetics:

  • Insufficient available evidence.

 

References

  1. Stajner, D., Popovic, B. M., Canadanovic-Brunet, J., and Boza, P. Free radical scavenging activity of three Equisetum species from Fruska gora mountain.Fitoterapia 2006;77(7-8):601-604. 16934417
  2. Oh, H., Kim, D. H., Cho, J. H., and Kim, Y. C. Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense.J Ethnopharmacol  2004;95(2-3):421-424. 15507369
  3. Tiktinskii, O. L. and Bablumian, I. A. [Therapeutic action of Java tea and field horsetail in uric acid diathesis]. Urol Nefrol (Mosk)1983;3(1):47-50. 6829092
  4. D’Agostino, M., Dini, A., Pizza, C., Senatore, F., and Aquino, R. Sterols from Equisetum arvense. Boll Soc Ital Biol Sper12-30-1984;60(12):2241-2245. 6529502
  5. Graefe, E. U. and Veit, M. Urinary metabolites of flavonoids and hydroxycinnamic acids in humans after application of a crude extract from Equisetum arvense. Phytomedicine1999;6(4):239-246. 10589442
  6. Nitta, A., Yoshida, S., and Tagaeto, T. A comparative study of crude drugs in Southeast Asia. X. Crude drugs derived from Equisetum species. Chem Pharm Bull (Tokyo)1977;25(5):1135-1139. 264177

 

Izvor: www.sigmaaldrich.com

German Commission E Monographs (Phytotherapy)

German Commission D Monographs preparation

Preslica sadrži visokovredna silicijumova jedinjenja, mangan, kalcium, gvožđe, flavonoide, fitosterole, glikozide, fenolne i akonitinske kiseline. Sposobna je apsorbovati jedinstvene minerale iz tla kao na primer silicijumov dioksid, koje nije lako naći u drugim biljkama. Zbog velike količine minerala i drugih nutrijenata preslicu nazivaju i biljkom koja remineralizira organizam. Preporučuje se za obnavljanje koštanih tkiva nakon traume ili telesne dekalcifikacije.












Pakovanje mL/ g:
 10 20 30 50 100 250 500 1000

Količina:
1 2 3 više 

 

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