Kleka (Juniperus communis L.)

Kleka (Juniperus communis L.)

BILJNI PREPARATI KLEKE:

TINKTURA, KLEKA HSS, hidroetanolni tečni ekstrakt sušenog ploda kleke, DER 1:5,

MATIČNA TINKTURA, KLEKA TM, hidroetanolni tečni ekstrakt svežeg ploda kleke, DER 1:2,

Juniperi tinctura DER 1:5,

Juniperi fructus recentis extractum ethanolicum liquidum DER 1:3.

 

BILJNI PREPARATI KLEKE:

TINKTURA, KLEKA HSS, hidroetanolni tečni ekstrakt sušenog ploda kleke, DER 1:5,

MATIČNA TINKTURA, KLEKA TM, hidroetanolni tečni ekstrakt svežeg ploda kleke, DER 1:2,

Juniperi tinctura DER 1:5,

Juniperi fructus recentis extractum ethanolicum liquidum DER 1:3.

 

ATC:

G01A – antiinfektivi i antiseptici,

G04BC – solvensi urinarnih konkremenata,

– diuretik.

 

U skladu sa:

Eu. Ph. 01.07.2015. monografijom: 1532 (Iuniperi pseudo-fructus), 1832 (Iuniperi aetheroleum).

EMEA 12.11.2009.: Assessment report on Juniperus communis L., pseudo-fructus

Fr. Ph. ANSM 2005 Juniperus communis ad praeparationes homoeopathicas

 

Biljni preparat u tečnom obliku (nerazblažen ili razblažen) za oralnu i lokalnu upotrebu.

 

a) Juniperus communis L.,pseudo-fructus (Juniper fresh berry).

 

Sastav:

a) tečni ekstrat (DER 1:2), ekstrakcioni rastvarač etanol 65% (v/v).

 

Juniperus communis L., sadrži 290 *(362) istraženih hemijskih jedinjenja koja ispoljavaju 637 *(742) dejstava (*podaci ažurirani juna 2016.).

 

Sadržaj:

a) minimalno 0,012% m/m, seskviterpena (sesquiterpene), izraženih kao cedren (cedrene) (MF: C15H24, MW: 204,351060 g/mol−1),

b) u većoj koncentraciji sadrži α-pinen, α-terpinen, kalcijum, hrom, kobalt, γ-cadinene, resin,

c) više od svih biljaka sadrži γ-elemen (seskviterpen), pentosan

d) sveži plod sadrži do 69% vode.

 

Indikacije:

biljni preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva.

Upotreba kod urogenitalnih, gastrointestinalnih, respiratornih, kožnih, endokrinih, kardiovaskularnih i neuroloških tegoba: mišićno-skeletni sistem; mišićna napetost, ukočenost, artritis, reumatizam, grčevi, tretman posle treninga, giht, bolovi donjeg dela leđa, … digestivni sistem; slab apetit, nadimanje, spora probava, prekomerna težina, … nervni sistem; letargija, nervna iscrpljenost, brige, … urogenitalni sistem; cistitis, infekcije bešike, urinarne tegobe, … respiratorni sistem; bronhitis, sinuzitis, kašalj, astma, prehlade, grip, obilna sluz, upala grla, … kožni sistem; celulit, edem, akne, gubitak kose, seboreja, herpes, …

Efektivno deluje na Escherichia coli i Helicobacter spp.

 

Dr. Džems Djuk (Dr. James Duke) u Handbook of Medicinal Herbs, 2nd Ed. (2002). CRC Press, navodi sledeće:

 

– ima jako dejstvo kod:

anoreksije, kamena u bubregu, urogenitalnih infekcija, …

 

– delotvoran kod:

artroza, ascita, karcinoma (bubrega, nogu, jetre, slezene), kandidijaza, kardiopatije, kondiloma, cistitisa, dijabetesa, dispepsije, edema, nadutosti i gasova, gihta, zadaha iz usta, gorušice, herpesa, povišenog krvnog pritiska, infekcija, upala, niskog krvnog pritiska, morbus Crohn, malarije, šuge, mikoza, reumatizma, otoka, tumora, virusnih i gljivičnih infekcija, zadržavanja tečnosti, poremećaja u radu endokrinog sistema, bolova u mišićima, …

 

– u narodnoj medicini kod:

amenoreje, anasarke, ateroskleroze, astme, bolova u leđima, bakterijskih infekcija, krvarenja, blenoreje, akutne i hronične infekcije bubrega, bronhitisa, katara, porođaja, hloroze, holecistitisa, prehlada, grčeva, zagušenja, zatvora, kašlja, proliva, vodene bolesti, dizenterije, dismenoreje, dispneje, disurije, encefalitisa, enteritisa, eneureze, epilepsije, eruktacije (povraćanja), groznice, fistula, gripa, peska i kamena u žuči i bubregu, gastritisa, gonoreje, glavobolje i migrene, zapalenja jetre i slezine, hidročele, histerije, enduracija (otvrdnuća), nesanice, žutice, leukoreje, lumbaga, mijalgija, nefroza, nervoze, neuralgije, neurastenije, neuroze, odontosisa, oftalmije, otitisa, pareza i paraliza, polipa, psorijaze, infekcija respiratornog trakta, pijelitisa, rinitisa, škrofula, infekcija, grlobolje, uganuća, tenesmusa (nedovoljnog pražnjenja creva), tonzilitisa, zubobolje, tuberkuloze, urogenitalnih zapalenja, čira, uretritisa, uteritisa, vaginitisa, veneričnih bolesti, parazita, loše probave, gubitka apetita, kod otežanog disanja, …

 

– spoljašnja primena kod:

zarastanje rana od opekotina i povreda, ujeda insekata, zmija i životinja, dekubitusa, gljivica, reumatizma, bradavica, dermatoza, uganuća,  …

 

– upotrebljava se kao:

diuretik, adstrigent, antireumatik, depurativ, antihipertenziv, rubefacijent, dezinfekcijens, antispazmatik, ekspektorans, antiastmatik, antiinflamatik, karminativ, tonikum, antibiotik, analgetik, antimikotik, antitrombotik, antiseptik, kozmetik, aromatik i digestiv, sekretolitik, dermetik, dijaforetik, epitelizant, antidijabetik, antiskorbutik, antibakterik, antivirotik, emenagog, antiarteriosklerotik, urinarni antiseptik, stimulator,…

 

Monografija nemačke E komisije (Commission E Monographs), terapijski vodič za biljne lekove, preporučuje Juniperus comunis pseudo-fructus kao jak diuretik i za tretman dispepsije.

 

Doziranje i način primene:

2 mL (80 kapi) podeljeno u 2 do 4 doze.

Biljni preparat KLEKA HSS i TM:

pojedinačna doza: 0,5-1 mL,

preporučena dnevna doza (PDD): 2 mL.

Oralna (sat vremena pre obroka) i lokalna primena.

Upotreba na koži: aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja.

Napraviti pauzu posle 4 nedelje neprekidne upotrebe.

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze.

 

Kontraindikacije:

preosetljivost na aktivne supstance,

preosetljivost na biljke porodice (genus Juniperus, family Cupressaceae).

 

Čuvanje:

na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju, u dobro zatvorenoj originalnoj ambalaži.

 

Rok upotrebe:

5 godina, posle prvog otvaranja 6 meseci.

 

Pakovanje:

50 mL i 100 mL, farmaceutske braon bočice standarno, 250 mL, 500 mL, 1L i 5 L na zahtev.

 

Nutritivne informacije:

KLEKA HSS i TM:

energetska vrednost u 100 mL: 1504 kJ/ 360 kcal,

u preporučenoj dnevnoj dozi (PDD) 2 mL: 30 kJ/ 7,17 kcal,

suve materije (DR) više od 2,5% (Fr. Ph.), 10,0% (GHP), RD 1,030-1,050.

 

Bez konzervanasa, proteina, masti i ugljenih hidrata.

 

KLEKA HSS i TM su rukom rađeni proizvodi. 

Analizu na teške metale, pesticide i mikrobiološku ispravnost preparata broj 4603120601 od 29.03.2016. godine izvršila ANAHEM LABORATORIJA BEOGRAD, u sklopu preparata RESPIRO 30.

CENOVNIK

 

TINKTURA, KLEKA HSS, hidroetanolni tečni ekstrakt sušenog ploda kleke, DER 1:5,

500,00 RSD za 50 mL,   1000,00 RSD za 100 mL

MATIČNA TINKTURA, KLEKA TM, hidroetanolni tečni ekstrakt svežeg ploda kleke, DER 1:2,

600 RSD za 50 mL,   1200 RSD za 100 mL.

 

http://www.biljni-preparati.com/preparati/kleka/                                                                                                              avgust 2016.

.

E Juniperus communis (Cupressaceae)

  1. Common names Yoshu-Nezu; Juniper; Ardic; A’Ra’R A’Di; Havrest; Ardij Aghaji; Enebro
upotreba reference
arterioskleroza Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
ujed (zmije) Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.
bronhitis Al-Rawi, Ali. 1964. Medicinal Plants of Iraq. Tech. Bull. No. 15. Ministry of Agriculture, Directorate General of Agricultural Research Projects.
bronhitis Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
karminativ Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.
karminativ Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
karminativ Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
cefalik Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
kolike Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.
deobstruent Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
depurativ Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
depurativ Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
dijaforetik Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
digestiv Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
diuretik Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.
diuretik Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
diuretik Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
diuretik Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
hidropsija Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
dizenterija Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
 emenagog Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.
emenagog Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
empyreumatic Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
fumigant Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
gleet
gonoreja
giht Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
giht Al-Rawi, Ali. 1964. Medicinal Plants of Iraq. Tech. Bull. No. 15. Ministry of Agriculture, Directorate General of Agricultural Research Projects.
giht Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
histerija Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
incense Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
bubrezi Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
bubrezi Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.
leukoreja
liniment Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
liniment Al-Rawi, Ali. 1964. Medicinal Plants of Iraq. Tech. Bull. No. 15. Ministry of Agriculture, Directorate General of Agricultural Research Projects.
liqueur Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
pluća
medicine
veterina Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
reumatizam
shortwindedness
koža
stimulant Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
stomahik Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
sudorifik Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
sudorifik Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
tenesmus Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
Tu Hartwell, J.L. 1967-71. Plants used against cancer. A survey. Lloydia 30-34.
urogenital Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.
urogenital Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.
venereal
vermifug Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.
bradavice Hartwell, J.L. 1967-71. Plants used against cancer. A survey. Lloydia 30-34.
rane, povrede Krochmal, Arnold and Connie. 1973. A guide to the medicinal plants of the United States. Quadrangle/The N.Y. Times Book Co.

 

Activity:

Pesticide, Antibacterial, Antioxidant, Antiinflammatory, Perfumery, FLavor, Cancer-Preventive, Antispasmodic, Antiviral, Fungicide, Antiseptic, Insectifuge, Antimutagenic, Antitumor, Irritant, Allergenic, Antifeedant, Aldose-Reductase-Inhibitor, Analgesic, Antiradicular, Antiradicular, Sedative, Hypocholesterolemic, Antileukemic, Hepatoprotective, Antiedemic, AntiHIV, Antidiabetic, Choleretic, Antiperoxidant, Antiaggregant, Candidicide, Cytotoxic, Antiacne, Nematicide, Immunostimulant, Antiasthmatic, Antiherpetic, Antihistaminic, Antihepatotoxic, Herbicide, Diuretic, Expectorant, ACE-Inhibitor, Allelochemic, Anticancer, Apoptotic, Hypotensive, Cardioprotective, Lipoxygenase-Inhibitor, Hypoglycemic, Vasodilator, Xanthine-Oxidase-Inhibitor, Insecticide, Antiproliferant, Antitumor-Promoter, Antiallergic, Antistaphylococcic, Chemopreventive, Antinitrosaminic, …

Reference:

Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.

Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

Aloe Research Council – Duke writeup of non-peer reviewd book by Coats and draft by Henry

Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine – A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.

Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387

Martindale’s 28th

Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994.

Lawrence Review of Natural Products, Jun-90.

Singleton, V.L. 1981. Naturally Occurring Food Toxicants: Phenolic Substances of Plant Origin Common in Foods. Advances in Food Research 27: 149-217.

Economic & Medicinal Plant Research, 5: 225.

Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 210.

Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X – The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95

Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155.

Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).

Shoyakugaku Zasshi, 44: 183.

McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82.

Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l’ORSTROM, Paris. 569 pp.

Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp.

Pedersen, M. 1987. Nutritional Herbology. Pederson Publishing. Bountiful, Utah. 377 pp.

Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.

Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.

Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46.

Podaci ažirirani oktobra 2016.

Izvor: dr Duke, James A.

 

Mechanism of Action

Pharmacology:

– Constituents: Monoterpenes (which make up most of the essential oil) – alpha- and beta-pinene, sabinene, limonene, terpinen-4-ol, alpha-terpineol, borneol, geraniol5, myrcene, camphene2, camphor, alpha-eudesmol1 and many others.

– Sesquiterpenes – beta-caryophyllene, delta-cadinene, farnesol, gamma-elemente, gamma-muurolene, humulene2, pregeijerene6 and many others.

– Diterpenes – sugiol, xanthoperol, 4-epi-abietic acid, 4-epi-dehydroabietic acid, 4-epi-palustric acid, 4-epi-abietinal, 4-epi-abietinol7, isopimaric acid, isocommunic acid, (-)ent-trans communic acid, sandracopimaric acid8 and many others.

– Neolignan glycosides – junipercomnoside A and B, icariside E4, and others9.

– Lignans – podophyllotoxin is present and is toxic to the nerves, gut and liver.10

– Tannins – gallocatechins.

– Flavonoids – isocutellarein, hypolaetin, kaempferol 3-O-alpha-rhamnopyranoside, quercitin, nicotiflorin, naringenin 7-O-beta-glucopyranoside and others.9

– Resin (fruit 80,000-100,000ppm); pentosan (fruit 60,000ppm); tannin (fruit 50,000ppm); essential oil (fruit 34,200ppm); cedrene (leaf 12,000-36,000ppm); alpha-pinene (fruit 9,200ppm); pectin (fruit 7,000ppm); sabinene (fruit 2,700ppm); P-hydroxybenzoic acid (plant 2,500ppm); cedrol (leaf 450-2,100ppm); myrcene (fruit 1,800ppm); terpinen-4-ol (fruit 1,050ppm); limonene (fruit 910ppm); beta-phellandrene (fruit 660ppm); alpha-terpinene (fruit 640ppm); gamma-terpinene (fruit 600ppm); beta-pinene (fruit 580ppm).

– Alpha-eudesmol inhibits calcium channels and appears to be neuroprotective in a stroke model.11

– Antifungal compounds are found in juniper such as oidiolactone C.12

– Isocrupressic acid in Juniperus communis has been identified as an active abortifacient compound.4

– Alpha- and beta-cedrene from Juniperus occidentalis have antimicrobial activity.13 15,16-epoxy-12-hydroxy-8(17),13(16),14-labdatrien-19-oic acid14

– Anti-inflammatory effects: A dry 80%-ethanolic extract of juniper, administered orally at 100mg/kg, reduced carrageenan-induced rat paw edema by 60% (p<0.001) compared to 45% for indometacin at 5mg/kg (p<0.01).15

-Diuretic effects: The diuretic action of juniper has been attributed to terpinen-4-ol.16 A 10% aqueous infusion of juniper or a 0.1% aqueous solution of juniper oil (with 0.2% of Tween 20 solubilizer) or a 0.01% aqueous solution of terpinen-4-ol were orally administered to groups of rats at 5mL/100g body weight; control groups were given water or water and 0.2% Tween orally and reference groups were given antidiuretic hormone (ADH; vasopressin) intraperitoneally at 0.004, 0.04 or 0.4 IU/100g. Compared to water, the 10% aqueous infusion of juniper and the 0.1% aqueous solution of juniper oil (in which the ratio of pinene fraction to terpinen-4-ol was 5:1) caused reductions of only 6% in diuresis over a 24-hour period, equivalent to the effect of 0.004 IU/100g of ADH, while the 0.01% solution of terpinen-4-ol caused a reduction of 30% in diuresis (p<0.01), equivalent to 0.4 IU/100g intraperitoneal of ADH. However, after continued daily administration at the same daily dose level, the two juniper preparations and terpinen-4-ol stimulated diuresis on days two and three, although only the 10% aqueous infusion of juniper exerted significant diuretic activity (+ 43% on day two; +44% on day three; p<0.05), suggesting that the diuretic effect is partly due to the essential oil and partly to hydrophilic constituents.17

After oral administration to rats of lyophilized aqueous extract of juniper at 1000mg/kg body weight, no increase in urine volume or excretion of Na+, K+ or Cl- ions could be demonstrated over a six-hour period compared to the effect of the same volume of water.18

– Hypoglycemic effects: An orally administered decoction of juniper showed significant hypoglycemic activity in normal rats after single doses equivalent to 250-500mg juniper/kg and in streptozotocin-induced diabetic rats after 24-day treatment with doses equivalent to 125mg juniper/kg. The effects were attributed to an increase in peripheral absorption of glucose, independent of plasma insulin levels.3

– Other: Intravenous administration of a lyophilized aqueous extract of juniper (25mg/kg body weight) to normotensive rats produced an initial transient rise in arterial pressure followed by a reduction of 27%. A dose of 1.2g/kg of the same extract produced an analgesic response of 178% as measured by thermal stimuli in mice.18

 

References

  1. Adams, R. P. Systematics of Juniperus section Juniperus based on leaf essential oils and random amplified polymorphic DNAs (RAPDs). Biochem Syst Ecol7-1-2000;28(6):515-528. 10793252
  2. Johnson, W. Final report on the safety assessment of Juniperus communis extract, Juniperus oxycedrus extract, Juniperus oxycedrus tar, Juniperus phoenicia extract, and Juniperus virginiana extract. Int J Tox2001;20 (sup 2):41-56.
  3. Sanchez, de Medina, Gamez, M. J., Jimenez, I., Jimenez, J., Osuna, J. I., and Zarzuelo, A. Hypoglycemic activity of juniper „berries“. Planta Med1994;60(3):197-200. 8073081
  4. Gardner, D. R., Panter, K. E., James, L. F., and Stegelmeier, B. L. Abortifacient effects of lodgepole pine (Pinus contorta) and common juniper (Juniperus communis) on cattle. Vet Hum Toxicol1998;40(5):260-263. 9778758
  5. Grainger Bisset, N. Max Wichtl herbal drugs and phytopharmaceuticals a handbook for practice on a scientific basis
  6. Cool, L. G. and Adams, R. P. A pregeijerene isomer from Juniperus erectopatens foliage. Phytochemistry2003;63(1):105-108. 12657304
  7. Tabacik C and Poisson, C. Diterpenes de Juniperus phoenicea: constituants mineurs. Phytochemistry1971;10:1639-1645.
  8. Topcu, G., Erenler, R., Cakmak, O., Johansson, C. B., Celik, C., Chai, H. B., and Pezzuto, J. M. Diterpenes from the berries of Juniperus excelsa. Phytochemistry1999;50(7):1195-1199. 10234860
  9. Nakanishi, T., Iida, N., Inatomi, Y., Murata, H., Inada, A., Murata, J., Lang, F. A., Iinuma, M., and Tanaka, T. Neolignan and flavonoid glycosides in Juniperus communis var. depressa. Phytochemistry2004;65(2):207-213. 14732280
  10. Leitner, J., Hofbauer, F., and Ackerl, M. [Poisoning with a podophyllin-containing wart-treating tincture]. Dtsch Med Wochenschr7-12-2002;127(28-29):1516-1520. 12111657
  11. Asakura, K., Matsuo, Y., Oshima, T., Kihara, T., Minagawa, K., Araki, Y., Kagawa, K., Kanemasa, T., and Ninomiya, M. omega-agatoxin IVA-sensitive Ca(2+) channel blocker, alpha-eudesmol, protects against brain injury after focal ischemia in rats. Eur J Pharmacol4-7-2000;394(1):57-65. 10771035
  12. Barrero, A. F., Arseniyadis, S., Quilez del Moral, J. F., Herrador, M. M., Valdivia, M., and Jimenez, D. First synthesis of the antifungal oidiolactone C from trans-communic acid: cytotoxic and antimicrobial activity in podolactone-related compounds. J Org Chem4-19-2002;67(8):2501-2508. 11950294
  13. Johnston, W. H., Karchesy, J. J., Constantine, G. H., and Craig, A. M. Antimicrobial activity of some Pacific Northwest woods against anaerobic bacteria and yeast. Phytother Res2001;15(7):586-588. 11746838
  14. Martin, A. M., Queiroz, E. F., Marston, A., and Hostettmann, K. Labdane diterpenes from Juniperus communis L. berries. Phytochem Anal2006;17(1):32-35. 16454474
  15. Mascolo N and et al. Biological screening of Italian medicinal plants for anti-inflammatory activity. Phytother Res1987;1:28-31.
  16. Janku, I., Hava, M., and Motl, O. [Diuretic substance from juniper (Juniperus communis L.)].Experientia6-15-1957;13(6):255-256. 13447954
  17. Stanic, G, Samarzija, I, and Blazevic, N. Time-dependent diuretic response in rats treated with juniper berry preparations. Phytother Res1998;12:494-497.
  18. Lasheras B and et al. Etude pharmacologique preliminaire de Prunus spinosa L. Amelanchier ovalis Medikus, Juniperus communis L. et Urtica dioica LPlant Med Phytother1986;20:219-226.

 

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Pakovanje mL/ g:
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