DMSO 33% v/v, 66% v/v i 100% v/v rastvor (Dimethyl sulfoxyde 33%, 66%, 100% solutio)

DMSO 33% v/v, 66% v/v  i 100% v/v rastvor (Dimethyl sulfoxyde 33%, 66%, 100% solutio)

 

PREPARATI DMSO-a: DMSO 33% v/v, 66% v/v i KONCENTROVANI RASTVOR 100% v/v.

 – namenjeni za prevenciju akutnog bola kod sportskih povreda.

U medicini, DMSO se pretežno koristi kao:
topikalni analgetik,
sredstvo za lokalnu primenu farmaceutika,
kao antiinflamatik i
antioksidans.
DMSO povećava brzinu apsorpcije nekih jedinjenja putem organskih tkiva, uključujući kožu, koristi u nekim sistemima leka kao transdermalni nosač.

DMSO je ispitan za lečenje brojnih stanja i bolesti, ali američka FDA je odobrila njegovu upotrebu samo za oslobađanje od simptoma pacijenata sa intersticijalnom cistitisom.

DMSO 33% v/v, 66% v/v i 100% v/v rastvor

PREPARATI DMSO-a: DMSO 33% v/v, 66% v/v i KONCENTROVANI RASTVOR 100%.

ATC Code
G04BX13 – Dimethyl sulfoxide
< G04BX – Other urologicals
< G04B – Urologicals
< G04 – Urologicals
< G – Genito urinary system and sex hormones from WHO

ATC Code
M02AX03 – Dimethyl sulfoxide
< M02AX – Other topical products for joint and muscular pain
< M02A – Topical products for joint and muscular pain
< M02 – Topical products for joint and muscular pain
< M – Musculo-skeletal system

U skladu sa: U skladu sa Eu. Phar. Dimethyl sulfoxide (0763)

Pharmacopée française  ANSM: 

USP29-NF24

MeSH Pharmacological Classification
Cryoprotective Agents

PubChem  Dimethyl Sulfoxide

Mineralni preparati u tečnom obliku (nerazblaženi ili razblaženi) za lokalnu (topikalnu) upotrebu.

a) DMSO solutio 33% v/v, 66% v/v i 100% v/v (DMSO dilution 33% v/v, 66% v/v i 100% v/v),

Sastav:

a) rastvor  33% v/v (DER 1:2), rastvarač (aqua valde purificata)  ultra čista voda EUROPEAN PHARMACOPOEIA 9.0,

b) rastvor  66% v/v (DER 2:1),rastvarač (aqua valde purificata)  ultra čista voda EUROPEAN PHARMACOPOEIA 9.0,

c) koncentrovani nerazblažen rastvor  100% v/v.

DMSO ispoljava mnogobrojna istražena dejstva.

 Sadržaj:

sadrži DMSO (pro analysi– analitičke čistoće 99,9%)

Molecular formula DMSO: C2H6OS or (CH3)2SO

Molecular Weight: 78.13344 g/mol

a) DMSO solutio 33 %v/v, 66% v/v, 100% v/v, (33, 66 i 100 mL DMSO-a na 100 mL),

b) ultračista voda (aqua valde purificata) UPW-elektroprovodljivosti ispod 1 µS/cm). EUROPEAN PHARMACOPOEIA 9.0:1927

 

Indikacije: Preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva. Upotreba kod sportskih povreda, reumatskih i išijadičnih bolova, …

Indikacije za upotrebu su: sportske povrede, …

Upotrebljava se kao: jak analgetik za lokalnu upotrebu

Doziranje i način primene: individualno u zavisnosti od godina starosti i stanja organizma 0,5 do 10 mL, maksimalno 15 mL dnevno. Uz preporuku ordinarijusa, maksimalna dnevna doza je 50 mL.

DMSO rastvor 33% v/v i 66% v/v , koncentrat 100% v/v:

po potrebi, do 15 mL (300 kapi) podeljeno u 2 do 4 doze.

Preparati DMSO:

pojedinačna doza: 0,5-1 mL, maksimalna preporučena dnevna doza (MPDD): 50 mL.

Oralna, sat vremena pre obroka N/A (nije primenljivo) i lokalna primena.

Upotreba na koži  aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja, razblažiti pre upotrebe čistom vodom. Koncentrovani rastvor OBAVEZNO RAZBLAŽITI pre upotrebe.

Napraviti pauzu posle 4 nedelje neprekidne upotrebe.

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze.

Kontraindikacije: preosetljivost na aktivnu supstancu, DMSO,

U većim koncentracijama: LD50 lab/anim. oralno 20000 mg/kg, intravenozno 10000 mg/kg, subkutano 5000 mg/kg,  mg/kg/danu x dana, 

Čuvanje: na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju, u dobro zatvorenoj originalnoj ambalaži.

 Rok upotrebe: 5 godina, posle prvog otvaranja 6 meseci.

 Pakovanje: 100 mL ( 3 1/2 fl oz), standardne farmaceutske braon bočice; 1L i 2,5 L na zahtev.

 

Nutritivne informacije:

DMSO 33% v/v, 66%v/v, 100%v/v: N/A (nije primenljivo)

energetska vrednost u 100 mL: 0 kJ/ 0 kcal,

u preporučenoj dnevnoj dozi (PDD) 2 mL: 0kJ/ 0 kcal,

suve materije (DR) više od N/A (nije primenljivo)

 

Bez konzervanasa, proteina, masti i ugljenih hidrata. DMSO rastvori su rukom rađeni proizvodi. 

Analizu broj 909-989/09/19 od 30.09. 2019. godine izvršila CH analitička laboratorija.Artikal: DIMETILSULFOKSID p.a. Serija: 909-989/09/19 Rok trajanja: 30.09.2024

 

CENOVNIK

Obrazac za izračunavanje cene:

300,00 + (% mLx0,120 ) RSD, u zavisnosti od koncentracije DMSO-a.

100 mL 100% v/v DMSO = 1500,00 dinara;

100 mL 66% v/v DMSO = 1100,00 dinara;

100 mL 33% v/v DMSO.= 700,00 dinara.

http://www.biljni-preparati.com/preparati/dmso-33-rastvor-dimethyl-sulfoxyde-33-solutio/

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Pharmacology
Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities. Dimethyl Sulfoxide also readily penetrates cellular membranes. The membrane-penetrating ability of dimethyl sulfoxide may enhance diffusion of other substances through the skin. For this reason, mixtures of idoxuridine and dimethyl sulfoxide have been used for topical treatment of herpes zoster in the United Kingdom.

Dimethyl Sulfoxide is a highly polar organic liquid that is used widely as a chemical solvent and a free radical scavenger. It shows a range of pharmacological activity including analgesia and anti-inflammation. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect cells and tissue during cryopreservation and has been used to treat extravasation damage caused by anthracycline-based chemotherapy.

 

Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee

MeSH Pharmacological Classification

Cryoprotective Agents
Substances that provide protection against the harmful effects of freezing temperatures. See a list of PubChem compounds matching this category.

Free Radical Scavengers
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries. See a list of PubChem compounds matching this category.

Solvents
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant and Hackh’s Chemical Dictionary, 5th ed) See a list of PubChem compounds matching this category.

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Toxicity to Animals:
Acute oral toxicity (LD50): 7920 mg/kg [Mouse]. Acute dermal toxicity (LD50): 40000 mg/kg [Rat].
Chronic Effects on Humans:
MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May cause damage to the following organs: blood, kidneys, liver, mucous membranes, skin, eyes.
Other Toxic Effects on Humans:
Slightly hazardous in case of inhalation (lung irritant). Slightly hazardous in case of skin contact (irritant, permeator), of ingestion, .

Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans:
May cause adverse reproductive effects (female fertility and fetotoxicity – post implantation mortality) and birth defects based
on animal data. May cause cancer (tumorigenic) based on animal data. May affect genetic material (mutagenic).
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects: Skin: Causes skin irritation. May cause urticaria(hives), skin rashes, and dermatitis. Dimethyl Sulfoxide is readily absorbed through skin and may carry other dissolved chemicals into the body. An unusual garliconion-oyster odor may develop on breath and body/skin. Absorption through skin may also cause diarrhea, and affect respiration(dyspnea, cyanosis), blood, behavior (fatigue, dizziness, sedation, headaches), vision (transient photophobia, and disturbances of color vision), urinary system (hematuria). Eyes: Causes eye irritation. May cause blurred vision, corneal opacity, chemical conjunctivitis. Inhalation: Causes respiratory tract irritation. Symptoms from exposure to high vapor concentrations may include coughing, shortness of breath, headache, dizziness and sedation.

Ingestion: Causes gastrointestinal tract irritation, and an usual garlic-onion-oyster may develop on breath, and body/skin. May affect behavior/ central nervous system, respiration (dyspnea). Symptoms may include nausea, vomiting, and diarrhea, abdominal pain, drowsiness, confusion, lethargy, agitation, disorientation, tremor, muscle weakness, chills, chest pains. May also affect liver (elevated liver enzymes, jaundice), cardiovascular system, and urinary system (hematuria, hemoglobinuria, renal tubular injury), eyes (transient photophobia and disturbances of color vision, conjunctive irritation) Chronic Potential Health Effects:
Skin: Chronic absorption may cause effects similar to that of acute skin absorption. Chronic skin contact may cause scaling p. 5 dermatitis. Ingestion: Repeated oral doses may affect the kidneys (hematuria), blood (normocytic anemia, changes in red
blood cell count), and metabolism (weight loss/anorexia), liver (jaundice).

Dimethyl sulfoxide pubchem

DMSO (DIMETHYLSULFOXIDE)

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WHAT OTHER NAMES IS DMSO (DIMETHYLSULFOXIDE) KNOWN BY?

Dimethylis Sulfoxidum, Dimethyl Sulfoxide, Dimethyl Sulphoxide, Dimethylsulfoxide, Diméthylsulfoxyde, Dimetilsulfóxido, Methyl Sulphoxide, NSC-763, SQ-9453, Sulfoxyde de Diméthyl, Sulphinybismethane.

WHAT IS DMSO (DIMETHYLSULFOXIDE)?

DMSO is a prescription medicine and dietary supplement. It can be taken by mouth, applied to the skin (used topically), or injected into the veins (used intravenously or by IV).

DMSO is taken by mouth, used topically, or given intravenously for the management of amyloidosis and related symptoms. Amyloidosis is a condition in which certain proteins are deposited abnormally in organs and tissues.

DMSO is used topically to decrease pain and speed the healing of wounds, burns, and muscle and skeletal injuries. DMSO is also used topically to treat painful conditions such as headacheinflammationosteoarthritisrheumatoid arthritis, and severe facial pain called tic douloureux. It is used topically for eye conditions including cataracts, glaucoma, and problems with the retina; for foot conditions including bunions, calluses, and fungus on toenails; and for skin conditions including keloid scars and scleroderma. It is sometimes used topically to treat skin and tissue damage caused by chemotherapy when it leaks from the IV that is used to deliver it. DMSO is used either alone or in combination with a drug called idoxuridine to treat pain associated with shingles (herpes zoster infection).

Intravenously, DMSO is used to lower abnormally high blood pressure in the brain. It is also given intravenously to treat bladder infections (interstitial cystitis) and chronic inflammatory bladder disease. The U.S. Food and Drug Administration (FDA) has approved certain DMSO products for placement inside the bladder to treat symptoms of chronic inflammatory bladder disease. DMSO is sometimes placed inside bile ducts with other medications to treat bile duct stones.

In manufacturing, DMSO is used as an industrial solvent for herbicides, fungicides, antibiotics, and plant hormones.

 

EFFECTIVE FOR…

  • Bladder inflammation (interstitial cystitis). DMSO is an FDA-approved product for the treatment of a bladder condition called interstitialcystitis. Washing the bladder with DMSO improves symptoms such as pain associated with interstitial cystitis.

POSSIBLY EFFECTIVE FOR…

  • Pain due to a condition called complex regional pain syndrome. Research suggests that applying DMSO 50% creamto the skin improves pain in people with complex regional pain syndrome.
  • Skin and tissue damage caused by chemotherapy when it leaks from the IV. Some chemotherapy drugs can cause skin and tissue damage if they leak from the veininto the skin or surrounding tissue. Research suggests that applying DMSO to the skin might prevent further damage in the event that this happens.
  • Shingles (herpes zoster). Research suggests that applying DMSO to the skin along with a drug called idoxuridine reduces lesions and swelling associated with shingles.
  • Inflammatory bladder disease. Research suggests that washing the bladder with DMSO improves symptoms in people with long-standing inflammatory bladder disease.
  • Pain caused by shingles. Research suggests that applying DMSO to the skin along with a drug called idoxuridine reduces pain caused by shingles. This condition is known as post-herpetic neuralgia.

POSSIBLY INEFFECTIVE FOR… A skin condition called scleroderma. Most research suggests that applying DMSO to the skin does not help treat symptoms in people with a skin condition called scleroderma.

LIKELY INEFFECTIVE FOR… Cancer. Research suggests that applying DMSO to the skin does not help treat cancer.

INSUFFICIENT EVIDENCE TO RATE EFFECTIVENESS FOR…

  • A condition called amyloidosis. Some early research suggests that applying DMSO to the skin, taking DMSO by mouth, or washing the bladder with DMSO might help treat amyloidosis.
  • Bile duct stones. Early research suggests that DMSO might help dissolve bile duct stones when infused into the bile duct with certain other solutions.
  • Cancer-related pain. Early research suggests that injecting DMSO intravenously (by IV) along with sodium bicarbonatemight improve quality of life in people with cancer-related pain.
  • Foot ulcers associated with diabetes. Early research suggests that applying DMSO to the affected skin might improve the healing of foot ulcers in people with diabetes.
  • High blood pressure in the brain. Some evidence suggests that DMSO might lower high blood pressureinside the brain when injected intravenously (by IV).
  • Early research suggests that applying DMSO to the skin might help decrease symptoms of osteoarthritis or rheumatoid arthritis(RA).
  • Stomach ulcers. Early research suggests that taking DMSO might be more effective than the drug cimetidinefor treating ulcers in people with ulcers caused by bacteria called Helicobacter pylori or those with ulcers that haven’t healed with other medications.
  • Pressure ulcers. Early research suggests that applying DMSO 5% cream to the skin along with massagedoes not help prevent pressure ulcers in people living in nursing
  • Helping skin heal after surgery. Early research suggests that applying DMSO to the skin might help the skin heal after surgery.
  • Tendon injuries (tendinopathy). Early research suggests that applying DMSO 10% gel to the skin might improve pain and jointmovement in people with tendon
  • Eye problems.
  • Gall stones.
  • Muscle problems.
  • Skin problems such as calluses.
  • Other conditions.

More evidence is needed to rate the effectiveness of DMSO for these uses.

HOW DOES DMSO (DIMETHYLSULFOXIDE) WORK?

DMSO helps medicines get through the skin and can affect proteins, carbohydratesfats, and water in the body.

ARE THERE SAFETY CONCERNS?

DMSO is LIKELY SAFE when used as a prescription medication. Don’t use products that are not prescribed by your health professional. There is concern that some non-prescription DMSO products might be “industrial grade”, which is not intended for human use. These products are POSSIBLY UNSAFE, as they can contain impurities that can cause health effects. To make matters worse, DMSO readily penetrates the skin, so it carries these impurities rapidly into the body.

Some side effects of taking DMSO by mouth or applying it to the skin include skin reactions, dry skin, headache, dizziness, drowsiness, nausea, vomiting, diarrheaconstipationbreathing problems, vision problems, blood problems, and allergic reactions. DMSO also causes a garlic-like taste, and breath and body odor.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking DMSO if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: There are reports that topical use of DMSO can change how insulin works in the body. If you use insulin to treat diabetes and also use DMSO, monitor your blood sugar closely. Insulin doses may need to be adjusted.

Certain blood disorders. Injecting DMSO intravenously (by IV) might cause red blood cells to break down. This might be a problem for people with certain blood disorders. DMSO might make these conditions worse.

Liver problems: DMSO might harm the liver. If you have liver conditions and use DMSO, be sure to get liver function tests every 6 months.

Kidney problems: DMSO might harm the kidneys. Kidney function tests are recommended every 6 months if you use DMSO and have a kidney condition.

ARE THERE ANY INTERACTIONS WITH MEDICATIONS?

Medications applied to the skin, eyes, or ears (Topical drugs) Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

DMSO can sometimes increase how much medicine the body absorbs. Applying DMSO along with medications you put on the skin or in the eyes or ears can increase how much medicine your body absorbs. Increasing how much medicine your body absorbs might increase the effects and side effects of the medicine.

Medications given as a shot (Injectable drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

DMSO (dimethylsulfoxide) might help the body absorb some medicines. Using DMSO and getting a shot might increase how much medicine the body absorbs and increase the effects and side effects of medications given as a shot.

Medications taken by mouth (Oral drugs) Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

DMSO (dimethylsulfoxide) might increase how much medicine your body absorbs. Taking DMSO along with medications taken by mouth might increase how much medicine your body absorbs. Increasing how much medicine your body absorbs can increase the effects and side effects of your medicines.

 

DOSING CONSIDERATIONS FOR DMSO (DIMETHYLSULFOXIDE). The following doses have been studied in scientific research:

APPLIED TO THE SKIN:

  • For prevention of some side effects of cancer treatment: 77-90% DMSO is typically applied under medical supervision every 3-8 hours for 10-14 days.
  • For shingles (herpeszoster): 5-40% idoxuridine in DMSO is within 48 hours after the appearance of a rash and applied every 4 hours for 4 days.
  • For nervepain: 50% DMSO solution has been used 4 times daily for up to 3 weeks.
  • For osteoarthritis: 25% DMSO gel has been used 3 times a day, and 45.5% DMSO topical solution has been used 4 times a day.

It’s important to note that DMSO is POSSIBLY UNSAFE when applied to the skin. There are reports that industrial-grade DMSO is being used for self-treatment of several disease conditions. Industrial-grade DMSO is not of the same quality as the DMSO that is used for drug research purposes since it may contain impurities. DMSO easily penetrates the skin and brings along impurities and other substances that may be hazardous to health.

INSIDE THE BLADDER:

  • For frequent urge to urinate (interstitial cystitis) and for chronic inflammatory bladder disease: Healthcare providers dripa DMSO solution into the bladder using a tube called a catheter. The catheter is removed and the patient is asked to hold the solution for a period of time before urinating.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

 

https://www.rxlist.com/dmso_dimethylsulfoxide/supplements.htm

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Na PubMed ima preko 36612 tekstova u kojima se pominje DMSO (ažurirano 01.01.2023.).

dmso topical 745 tekstova

dmso treatment 14390 tekst

dmso cancer 5439 tekstova

X X X X X 

Pharmacology of DMSO.
Jacob SW

X X X X X

An alternative mechanism for radioprotection by dimethyl sulfoxide; possible facilitation of DNA double-strand break repair.
Kashino G, Liu Y, Suzuki M, Masunaga S, Kinashi Y, Ono K, Tano K, Watanabe M.

Abstract
The radioprotective effects of dimethyl sulfoxide (DMSO) have been known for many years, and the suppression of hydroxyl (OH) radicals induced by ionizing radiation has been thought to be the main cause of this effect. However, the DMSO concentration used was very high, and might be toxic, in earlier studies. In the present study, we administered a lower, non-toxic concentration (0.5%, i.e., 64 mM) of DMSO before irradiation and examined its radioprotective effects. Colony formation assay and micronucleus assay showed significant radioprotective effects in CHO, but not in xrs5, which is defective in the repair function of DNA double-strand breaks. The levels of phosphorylated H2AX and the formation of 53BP1 foci 15 minutes after irradiation, which might reflect initial DNA double-strand breaks, in DMSO-treated CHO cells were similar to those in non-treated cells, suggesting that the radioprotective effects were not attributable to the suppression of general indirect action in the lower concentration of DMSO. On the other hand, 2 hours after irradiation, the average number of 53BP1 foci, which might reflect residual DNA double-strand breaks, was significantly decreased in DMSO-treated CHO cells compared to non-treated cells. The results indicated that low concentration of DMSO exerts radioprotective effects through the facilitation of DNA double-strand break repair rather than through the suppression of indirect action.

PMID: 21116101
[PubMed – indexed for MEDLINE] Free full text

X X X X X

Pre prve upotrebe obavezno pročitajte ovo uputstvo. Uputstvo sačuvajte, možda ćete poželeti da ga ponovo pročitate. Dimetilsulfoksid ( DMSO ) je prirodna vodotopiva tečnost. To je bezbojna nesintetisana tečnost ekstrahovana i dobijena preradom sokova iz celuloznog drveta, kao takav on nije lek i ne može se registrovati kao lek. DMSO se u prirodi javlja u tragovima u biljkama, svežoj vodi, u okeanima i u kiši. Može da iritira kožu preosetljivih ljudi pa pre upotrebe testirajte malu količinu (prsnite ) na mali prostor na ruci. Ako je reakcija: crvenilo , svrab I jako pečenje kože, to će nestati za desetak minuta ali ovaj proizvod onda nije za Vas. Uvek treba da očistite oblast koju želite da tretirate. Uklonite I vaše omiljene kreme jer DMSO će ih rastvoriti I Vaša koža će to da upije bez selekcije, tako da postoji rizik da neke toksične supstance unesete u svoj organizam. Većina DMSO-a će prodreti u kožu u roku od 15 minuta. Izbegavajte kontakt sa svim toksičnim supstancama tri sata nakon upotrebe DMSO-a. DMSO se može koristiti kod povrede skočnog zgloba ( teniseri nakon prskanja po bolnom mestu ubrzo nastavljaju meč ), migrenozni bolovi će utihnuti ubrzo nakon apliciranja, bitno je reagovati odmah nakon što osetite pojavu, I modrice će izbledeti ako blagovremeno reagujete. DMSO ima dobra krioprotektivna svojstva: pokazao se izuzetno dobro kod promrzlina prstiju, brojna su svedočenja u korist DMSO-a, izbegnute su mnoge amputacije. Izvrstan je I kod opekotina od vatre ili električnog luka, regeneracija tkiva je uglavnom potpuna I sa vraćenim funkcijama . Prilikom nanošenja možete smanjiti iritaciju ako tapkate čistim prstima po koži, ubrzaćete proces I efekti će trajati duže. Možda ćete želeti da eksperimentišete sa količinom DMSO-a koju nanosite da vidite kako to utiče na Vaš bol, tako možete naći minimalni iznos koji olakšava bol. Ali blago peckanje pri upotrebi ne treba da Vas obeshrabri.

Koliko često se može koristiti DMSO ? Učestalost upotrebe zavisi od toga da li je Vaš problem akutan ( nešto što se desi a ne vraća, kao oticanje uganutog zgloba ) ili je hroničan ( traje dugo kao kod artritisa). Kod akutnih stanja preporučuje se primena na svaka dva sata u narednih šest do osam sati od povređivanja. Nakon toga, u narednih nedelju dana primenjivati na svakih četiri do šest sati, najduže tri nedelje. Kod hroničnih stanja, možda ćete primetiti odmah smanjenje bolova ali do maksimalnih koristi nekada može da potraje I par meseci pa I godinu dana. Jedna aplikacija dnevno se preporučuje. DMSO se oslobađa iz organizma u roku od 24h. Ipak, preporučuje se pauziranje dva dana za redom I kod akutnih I kod hroničnih stanja ako su u pitanju višemesečne primene jer DMSO ima kumulativan efekat, što se duže koristi treba umanjivati doze ili praviti česte pause u primeni. Svaka osoba drugačije doživljava I reaguje na bol.

Upozorenja kod korišćenja DMSO
Trudnicama se ne preporučuje upotreba
Nemojte ga koristiti sa lekovima, acetonom, kiselinama – zbog moguće interakcije
Povećava efekte lekova kao što su razređivači krvi, steroidi, lekovi za srce, sedativi itd.
Uvek prskajte na čistu, opranu kožu.
Izbegavajte prskanje u oči, isperite ako do toga dođe
Čuvajte van domašaja dece

Ostala upozorenja

  1. DMSO nemojte koristiti na mestima gde vas je ujeo insekt jer toksične supstance iz seruma insekta mogu se proširiti po zoni ujeda I izazvati Vašu nelagodnost.
  2. Iako pomaže kod zaraslih rana u bržem smanjenju ožiljka, ne treba ga nanositi na inficirane otvorene rane.
  3. Ostanite daleko od toksičnih supstanci za vreme I posle primene DMSO-a najmanje tri sata.
  4. Ako slučajno prospete otrovne supstance na sebe nakon korišćenja DMSO-a , ne paničite, samo ih odmah isperite vodom I sapunom.
  5. Prilikom upotrebe DMSO oseća se miris nalik na beli luk, to Vam može izazvati neprijatnost u društvu.

DMSO pomaže u detoksikaciji od teških i toksičnih metala. Sumpor se vezuje sa toksičnim i teškim metalima ( živa, olovo, aluminijum, kadmijum, arsen, nikl ) i eliminiše ih preko mokrenja, defekacije i znojenjem. DMSO ima radioprotektivne efekte, u niskim koncentracijama sprečava raspad dvostrukog lanca DNK i mutagene efekte zračenja u ćelijama. Može se koristiti neposredno pre snimanja preloma rentgenom, pogotovu je dobro aplicirati ga

 

DMSO – primena Koristi se lokalno da smanji bol i ubrza zarastanje rana, opekotina, promrzlina, mišića i skeletnih povreda. Takođe se lokalno koristi za smanjenje bolnih stanja kao što su glavobolja, zubobolja, oticanje, osteoartritis, reumatoidni artritis i teški facijalni bolovi. Lokalno se koristi i kod očnih slučajeva uključujući kataraktu, glaukom, retinu… Kod problema sa stopalima, uklučujući čukljeve, bradavice i gljivice među prstima. Kod problema sa kožom uključujući keloidne ožiljke i sklerodermu. Koristi se topikalno kod popravke oštećene kože i tkiva izazvanih hemoterapijom. Koristi se sam ili u kombinacijama sa drugim sredstvima kod herpes zoster infekcije. Intravenski (ili oralno ako se desi van naselja) u hitnim situacijama da smanji abnormalno visok krvni pritisak u mozgu. Takođe se daje intravenozno za uklanjanje infekcija bešike (intersticijalni cistits) i hronične upale bešike. Sa drugim supstancama pomaže rastapanje kamena u žučnim putevima. DMSO je jedan od najmoćnijih antioksidanata, daleko superiorniji od bilo kog vitamina ili minerala zbog transportnih, hemijskih i penetracijskih sposobnosti.

DMSO sa lakoćom prolazi kroz kožu i druge membrane. Takođe je u stanju da poboljša prohodnost nekih membrana što znači da će manji molekuli moći lakše da prođu kroz ove membrane. Zato može biti korišćen da transportno pomogne nekim lekovima da budu apsorbovani od strane kože ili da omogući nekim jedinjenjima da prodru u druga tkiva. DMSO je u stanju da preuredi kolagena vlakna što ga čini korisnim kod tretmana za post- hirurške adhezije. Lekari su takođe primetili da DMSO ima moćna antiinflamatorna dejstva što znači da je u stanju da lokalno inhibira imuni sistem. Ovo ga čini korisnim kod tretiranja dermatitisa i određenih vrsta artritisa. Činjenica da brzo prodire kroz kožu znači da može da se direktno primenjuje na ciljanu zonu sa rapidnim efektom. DMSO stimuliše bolju cirkulaciju krvi kroz krvne sudove čime se povećava brža I bogatija isporuka kiseonika I smanjuje lepljivost trombocita. DMSO se koristi kao analgetik protiv bolova. Zato što može da raspusti male jone i prolazi kroz membrane, DMSO može izmeniti nivo kalcijuma , magnezijuma i natrijuma kako: u – tako: I van nervnih vlakana. Nervima je prisustvo ovih minerala potrebno u određenim koncentracijama u cilju stvaranja električne energije za prenos nervnog signala. Blokiranjem tih nerava koji prenose informaciju bola, DMSO je u stanju da umanji bolove. Kao nosač hranljivih materija primenjuje se da olakša transport vitamina i supstanci kroz ćelijske membrane što omogućava dopremu hranljivih materija u ćelije. To je velika korist koju ni jedna druga supstanca ne poseduje. Kao moćan rastvarač takođe je u stanju da prodre kroz sva tkiva osim kroz nokte, kosu i zubnu gleđ.

DMSO u terapiji kancera U dokumentovanim istraživanjima literature i u aktuelnim slučajevima, svedoci smo iz prve ruke : dokazi pokazuju ukupne visoke ocene oporavka od kancera koji su metastazirali na limfnim čvorovima i drugim delovima tela. Najveći uspesi se postižu u borbi protiv limfoma, glioblastoma, melanoma, prostate i debelog creva. Poznato je da DMSO delujući kao nosač i rastvarač , pomešan sa dekstrozom deluje kao „ trojanski konj“ kada izvuče tumor kroz ćelijski zid koji se hrani dekstrozom. DMSO zatim uništava ćelije kancera a ne utiče na normalno, zdravo tkivo. DMSO smanjuje energetski nivo ćelija kancera uzrokujući da postanu benigne.

DMSO I moždani udar Moždani udari su treći najveći ubica u svetu. Oni su takođe primarni uzrok ozbiljnih invaliditeta. Ako se primeni u prvih nekoliko sati nakon moždanog udara , dokazano je da DMSO rastapa ugrušak koji je izazvao udar, ovo oporavlja cirkulaciju I izbegava paralizu. Najbolje je intervenisati intravenozno. Ako ste daleko od lekara potražite spas oralnim uzimanjem I na taj način ćete poboljšati cirkulaciju I rastapati koagulum. Postoje svedočenja da je 30 ml 50% DMSO-a u malo voćnog soka u gutljajima na svakih 15 minuta za dva sata I zatim svakih pola sata narednih dva sata vratilo u normalu pacijenta. Nakon par dana pacijent se sasvim oporavio. Dr. Morthon Voker kaže: postoji velika potreba za istraživanjem o upotrebi masivnih doza DMSO ( 2 gr po Kg telesne težine ) u lečenju srčanih udara. Supstanca koja može da spreči posledice moždanog udara je nešto što mnogi ljudi žele da vide u svojim kućnim ormarićima prve pomoći. Neurohirurg dr Jack De la Torre je professor fiziologije I neurohirurgije na Univerzitetu u Novom Meksiku u Albukeriju. On I dr Stanley W. Jacob veruju da DMSO treba da bude u svakoj ambulanti I hitnoj pomoći kako bi odmah primenjivali intravenoznu terapiju žrtvama moždanog udara. Ako bi takva praksa bila uspostavljena brojni ljudi bi ostali u životu . Ne samo da bi mnogi životi bili spašeni već bi užasne poteškoće usled paralize ili gubitka govora mogle da budu sprečene. Isto važi I za teške saobraćajne udese kada dolazi do teških fraktura glave, kičme I sl. Uštede u medicinskom sistemu države bile bi ogromne.

DMSO – paraplegija Dr Jacob je prvi dao DMSO intravenozno ljudima koji su već paralizovani- paraplegičarima I oni su malo po malo povratili funkcije udova. Poznat je slučaj kvadriplegičara koji se oporavio dovoljno da može da ide na koledž a potom da radi u banci. Nedavna studija u Turskoj gde je kombinovan DMSO sa fruktozom difosfata u 20 pacijenata sa povredama glave pokazala se veoma efikasno u smanjivanju intrakranijalnog pritiska. Dr De la Torre izjavljuje iz svog iskustva da ništa drugo ne može tako brzo smanjiti intrakranijalni pritisak kao DMSO. DMSO širi krvne sudove, protok kroz karotidne arterije raste posle primene DMSO-a datog intravenozno. Kod povreda kičme, intervencija u visini kičmenog regiona traume sprečava smanjenje protoka kiseonika I krvi pošto su krvni sudovi stisnuti ili u fazi gašenja, bez nekog brzog tretmana I pospešenja protoka ubrzo dolazi do paralize. Sa DMSO infuzijom odmah nakon povrede kičme ( ili moždanog udara) sve ovo je sprečeno.

DMSO – sporedni efekti Prijavljene su retke pojave glavobolje, osećaj jeze i peckanje po tretiranim regijama. Retke su i prijave osećanja mučnine i povraćanja. DMSO je bezbojna uljana tečnost sa mirisom nalik na beli luk zbog sumpornog jedinjenja nalik na miris belog luka.

DMSO – bezbednost upotrebe Trudnice, žene koje žele da zatrudne I žene koje doje ne bi trebale da koriste DMSO. Držati dalje od dece. Kada se koristi prema odobrenim smernicama, DMSO je generalno bezbedan i dobro se podnosi. Za integrisanje sa bilo kojim drugim supstancama posavetujte se sa svojim lekarom pre korišćenja. DMSO je potpuno prirodan proizvod i apsolutno netoksičan u preporučenim dozama.

Neki načini korišćenja DMSO U medicini, DMSO se koristi kao topikalni analgetik, sredstvo za lokalnu primenu lekova, kao anti- inflatorno sredstvo i antioksidans: oralno i intravenozno. Pošto povećava brzinu apsorpcije nekih jedinjenja kroz organska tkiva, uključujući kožu, može se koristiti kao sistem isporuke lekova. Često se kombinuje sa antifungalnim lekovima što im omogućava dubok prodor ( npr: u prst i pod nokat ).

DMSO I sport Sportisti znaju da nešto miriše na beli luk ali ako ih burzitis I kalcifikacija u ramenu sprečava da jedva podignu ruku onda injekcija u rame može da im pomogne. Kalcifikacija će nestati za mesec dana. Ako je povređen skočni zglob teniser neće predati meč. TV gledaoci se često pitaju: Šta li je to sportski terapeut isprskao kad teniser nastavlja borbu kao da se ništa nije desilo? Kao da nema bolova ?

Uputstvo za topikalno doziranje DMSO se brzo apsorbuje kroz kožu, zato površina koja se tretira ( I prsti kojima se tapka po koži ) moraju biti čisti. Isperite sve losione I kreme sa kože pre nanošenja DMSO-a. Nemojte koristiti rukavice jer neki lateks materijali mogu da se rastope u prisustvu DMSO-a. ( Ako želite korišćenje rukavice, testirajte je pre upotrebe tankim slojem DMSO-a I ostavite da prenoći ). Naprskajte tanak sloj na kožu I tapkajte, nemojte trljati ili masirati regiju. Možete koristiti čist pamuk ili tufer, ali nemojte koristiti sintetičke ili obojene tkanine, hemikalije ili boje mogu da prodru u kožu. Taj tanki sloj će biti apsorbovan za desetak minuta. Tretirana površina će biti bezbedno suva za sat vremena. U tom međuvremenu izbegavajte prisustvo dima, sprejeva, osveživača prostorija I slično.

Uputststvo za oralno korišćenje 33% rastvora Uobičajene oralne doze za DMSO su 5-10 ml dnevno. Zbog nepoznatog nivoa vaše tolerancije krenite sa manjim dozama. Pomešajte DMSO sa sokom ceđenog paradajza ili sokom voća. Nemojte koristiti flaširane proizvode već iscedite prirodni sok.

Infuziono doziranje – protokol Sporim intravenskim metodom tokom perioda od 2-3 sata. Protokol uključuje dodavanje 50 cc DMSO u glukozu 500 cc ili slani rastvor, iskapavanjem u venu ruke pacijenta. Pre apliciranja uraditi procenu tolerancije . Ovaj metod treba da administriraju samo prikladno kvalifikovani lekari.

Još o DMSO Ekspozicija kože. DMSO lako prodire u kožu ( 176 +- 42 g/ m2 ) u poređenju sa, na primer vodom, (14.8 +- 0,1 g/ m2 kože ). DMSO je diuretik ali nema tragova oštećenja bubrega ni u jednoj od brojnih studija čak ni nakon brojnih ponavljanja tretmana. DMSO nije mutagen, biocidan je već pri koncentracijama od 5%. Nema neželjenih genetičkih efekata, nije embriotoksičan I nije naveden kao karcirogen od strane regulatornih agencija.

DMSO u prirodi DMSO je pronađen u tragovima u atmosferi, u okeanima, kiši. Ima ga u voću, povrću I pićima. Identifikovan je u detelini, špargli, ječmu, pasulju, cvekli, kupusu, krastavcima, kukuruzu, luku, blitvi, paradajzu, jabukama, malinama, menti, pivu, mleku, kafi ,čaju itd. I to u koncentracijama do 16 ppm.

Šta još reći? Ako je DMSO tako dobar, onda gde je? Zašto se ćuti o tome? Zašto se ne koristi? To je druga priča. Tužno je kada se pomisli na posledice stradanja koje su mogle da budu izbegnute. Ali ova priča još nije gotova. DMSO se još uvek može naći samo u prodavnicama zdrave hrane gde malo ljudi zalazi ili se prodaje putem interneta. Izuzetak su zemlje koje nisu pod uticajem zapada. U tim zemljama se DMSO slobodno prodaje u apotekama , bez recepta. DMSO je veoma siguran, netoksičan I efikasan I naći će svoj put do onih koji znaju da prepoznaju prave vrednosti koje neko uporno sakriva od ljudi.

Odricanje odgovornosti Tekstovi koje smo vam ovde ponudili mogu da budu samo informacije ali ne mogu da budu zamena za savet ili medicinsku negu vašeg licenciranog lekara. Nama nije namera da vam prepisujemo DMSO u terapijske svrhe. Potražite savet od vašeg lekara ukoliko želite da napravite izmene za svoju ličnu dobrobit. Nažalost, mnogi lekari nisu obavešteni o postojanju i prednostima ovih proizvoda. Vaše zdravlje je vaš izbor.

Postoji i dostupna je ogromna biblioteka sa informacijama o ovim proizvodima. 

Review

Jan-Jun 1985;5(1-2):1-33.

Medical use of dimethyl sulfoxide (DMSO)

  • PMID: 3916302

Abstract

DMSO is a clear odorless liquid, inexpensively produced as a by-product of the paper industry. It is widely available in the USA as a solvent but its medical use is currently restricted by the FDA to the palliative treatment of interstitial cystitis and to certain experimental applications. Cutaneous manifestations of scleroderma appear to resolve (albeit equivocally) following topical applications of high concentrations of DMSO. A limited number of small clinical trials indicate that intravenous DMSO may be of benefit in the treatment of amyloidosis, possibly by mobilizing amyloid deposits out of tissues into urine. Dermal application of DMSO seems to provide rapid, temporary, relief of pain in patients with arthritis and connective tissue injuries. However, claims for antiinflammatory effects or acceleration of healing are currently unwarranted. There is no evidence that DMSO can alter progression of degenerative joint disease, and, for this reason, DMSO may be considered for palliative treatment only and not to the exclusion of standard antiinflammatory agents. The safety of DMSO in combination with other drugs has not been established; neurotoxic interactions with sulindac have been reported. In experimental animals, intravenous DMSO is as effective as mannitol and dexamethasone in reversing cerebral edema and intracranial hypertension. An initial clinical trial in 11 patients tends to support this latter application. DMSO enhances diffusion of other chemicals through the skin, and, for this reason, mixtures of idoxuridine and DMSO are used for topical treatment of herpes zoster in the UK. Adverse reactions to DMSO are common, but are usually minor and related to the concentration of DMSO in the medication solution. Consequently, the most frequent side effects, such as skin rash and pruritus after dermal application, intravascular hemolysis after intravenous infusion and gastrointestinal discomfort after oral administration, can be avoided in large part by employing more dilute solutions. Most clinical trials of DMSO have not incorporated the components of experimental design necessary for objective, statistical evaluation of efficacy. Randomized comparisons between DMSO, placebo and known active treatments were rarely completed. Final approval of topical DMSO for treatment of rheumatic diseases in particular will require a multi-center, randomized comparison between high and low concentrations of DMSO and an orally-active, nonsteroidal antiinflammatory agent.(ABSTRACT TRUNCATED AT 400 WORDS)

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