Preparati

CRVENA DETELINA TM

Trifolii floris recentis extractum ethanolicum liquidum DER 1:2

Preparati crvene deteline su namenjeni pušačima, ublažavanju kašlja, kod problema sa kožom, za sprečavanje simptoma izazvanih u menopauzi,  kao antidot kod trovanja teškim metalima, nikotinom i kofeinom, kod zloupotrebe alkohola, lekova i osobama preko 50 godina starosti, kardio i neuroprotektor.

BILJNI PREPARAT CRVENE DETELINE:

MATIČNA TINKTURA, HIDROETANOLNI TEČNI EKSTRAKT SVEŽEG CVETA

CRVENA DETELINA TM

ATC:

– cirkulatonik,

– detoksikant,

– nutritivni tonik.

U skladu sa Eu. Ph. 8  monografijom: Trifolium pratense ad praeparationes homoeopathicas, method 3a,

Deutsches Homöopathisches Arzneibuch – HAB: Trifolium pratense  ad praeparationes homoeopathicas (Trifolium pratense  pour préparations homéopathiques), method 3a,

HPUS 78: Trifolium pratense hom. HPUS78. 

a) Trifolium pratense, flos (Red clover fresh flower).

Biljni preparati u tečnom obliku (nerazblaženi ili razblaženi) za oralnu i lokalnu upotrebu.

Sastav:

a) tečni ekstrakt (DER 1:2), ekstrakcioni rastvarač etanol 65% (v/v),

Trifolium pratense L., sadrži preko 297 *(413) istraženih hemijskih jedinjenja koja ispoljavaju 683 *(746) dejstava *(podaci ažurirani avgusta 2016.).

Sadržaj:

a) minimalno 0,007% m/m o-kumarne kiseline (o-coumaric acid/ 2-Hydroxycinnamic acid) (MF: C₉H₈O₃, MW: 164,15802 g/mol⁻¹),

b) u većoj koncentraciji sadrži cinamil alkohol, daidzein, etil cinamat, heksanol, izoflavone, fosfor, kalijum, niacin, fenole, kalaj,

c) više od svih biljaka sadrži biohanin-a (flavonoid, izoflavon, fitoestrogen-antikancerogenik), cinamaldehid (cinnamaldehyde), cinamil heksoanat, formononetin (glikozid-fitoestrogen), o-kumarnu kiselinu (hidroksicinamsku-melilotsku kiselinu), pratenol A, pratenol B, pratensein (izoflavon-antiaterosklerotik), feniletil acetat (fenetil acetat-phenylethyl acetate), sissotrin, …

d) cvet sadrži do 82,3 % vode.

Indikacije: biljni preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva.

Upotreba kod kardiovaskularnih, respiratornih, urogenitalnih, gastrointestinalnih, kožnih i endokrinih tegoba, imunostimulator.

Efikasno čisti krv od toksičnih materija, teških metala, nikotina i kofeina. Koristi se u tradicionalnoj medicini Indije kao deobstruent, antispazmodik, ekspektorans, sedativ, antiinflamatik i u terapiji dermatoza. U alternativnoj medicini u terapiji kašlja, oboljenja limfnog sistema i različitih karcinoma, kao i drugih bolesti.

Dr. Džems Djuk (Dr. James Duke) u Handbook of Medicinal Herbs, 2nd Ed. (2002). CRC Press, navodi sledeće: 

– ima jako dejstvo kod: tegoba u i posle menopauze, ateroskleroze, kardiopatije, visokog nivoa holesterola, triglecirida i lipida, infekcija, trovanja jetre, imunosupresije, …

– delotvoran kod: bronhitisa, Ca. (dojke, kolona, pankreasa, želuca, intestinuma, tonzila), kardiopatije, nazeba, kongestije, kašlja, grčeva, inflamacija, osteoporoze, pertusisa, Tu., plućnih tegoba, demencije, …

– u narodnoj medicini kod: anoreksije, astme, atletskog stopala, akutnog i hroničnog nefritisa praćenog edemom i hipertenzijom, opekotina, Caked Breast,  Ca., katara, holecistitisa, konjunktivitisa, konstipacije, žuljeva, dermatitisa, dismenoreje, ekcema, dispepsije, dispneje,  gihta, epitelioma, hepatitisa, Hot Flash-a i drugih simptoma u menopauzi, insomnije, žutice, laringitisa, lepre, leukoreje, mastitisa, malih boginja,  nefritisa, nervne napetosti,  oftalmije, pertusisa, očnih tegoba-ftizije, psorijaze, respiratornih tegoba, reumatizma, skrofula, spazama, splenitisa, edema-otoka, sifilisa, veneričnih bolesti (VD), zastoja tečnosti, rana – povreda kože. 

– spoljašnja primena kod: akni, žuljeva, rana, dermatoza, … 

– upotrebljava se kao: jak estrogenik, antiaterosklerotik, zatim antiangiogenik, antikarcinogenik, antiinflamatik, antiosteoporotik, antiseptik, antispazmodik, dekongestant, ekspektorant,  mastogenik (za uvećanje grudi),  progesterogenik, u tradicionalnoj medicini alternativ, antipsorijatik, antireumatik aperitiv, adstringent, bitter, holagog, depurativ, diuretik, emenagog, sedativ, tonik, vulnerar, aperient, detergent, antiastmatik, … 

Monografija nemačke E komisije (Commission E Monographs), terapijski vodič za biljne lekove, preporučuje Trifolium pratense za tretman povišenog nivoa lipida i holesterola u krvi, visoke vrednosti krvnog pritiska i starosno zavisnih promena kardiovaskularnog sistema.

Doziranje i način primene:

do 2 mL (80 kapi) podeljeno u 2 do 4 doze.

Biljni preparat CRVENA DETELINA TM:

pojedinačna doza: 0,5-1 mL, preporučena dnevna doza (PDD): 2 mL.

Oralna (sat vremena pre obroka) i lokalna primena.

Upotreba na koži: aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja.

Napraviti pauzu posle 4 nedelje neprekidne upotrebe.

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze od po nedelju dana.

Kontraindikacije: preosetljivost na aktivne supstance, preosetljivost na biljke porodice (genus Trifolium, family Fabaceae), apsolutna kontraindikacija trudnoća i dojenje zbog estrogenih akrivnosti.

Preparati crvene deteline sadrže kumestrol (coumestrol), fitoestrogen. Zbog svoje aktivnosti na receptore estrogena, crvena detelina je kontraindikovana kod osoba sa istorijom raka dojke, endometrioza, kancera jajnika i materice, fibroida materice i drugih estrogen osetljivih stanja.

Interakcije: ne postoje adekvatni podaci o mogućim interakcijama. Izoflavoni su supstrati CYP-a i potencijalno mogu da dovedu do interakcije sa drugim metabolitima koji se metabolišu ovim enzimom.

Preparate crvene deteline treba pažljivo uzimati sa estrogenima, tamoksifenom, antikoagulansima – lekovima koji utiču na koagulaciju krvi i agregaciju trombocita, oralnim kontraceptivima, aspirinom, jedinjenjima progesterona. 

Čuvanje: na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju,  u dobro zatvorenoj originalnoj ambalaži. 

Rok upotrebe: 5 godina, posle prvog otvaranja 6 meseci. 

Pakovanje: 50 mL i 100 mL, farmaceutske braon bočice standarno, 250 mL, 500 mL, 1L i 5 L na zahtev.

Nutritivne informacije:

CRVENA DETELINA TM:

energetska vrednost u 100 mL:  1504 kJ/ 360 kcal,

u preporučenoj dnevnoj dozi (PDD) 2 mL: 30kJ/ 7,17 kcal,

suve materije (DR) više od 2,0% (HAB), RD 0,900 – 0,930.

Bez konzervanasa, proteina, masti i ugljenih hidrata. 

CRVENA DETELINA TM je rukom rađen proizvod. 

Analizu na teške metale, pesticide i mikrobiološku ispravnost preparata broj 4603120601 od 29.03.2016. godine izvršila ANAHEM LABORATORIJA BEOGRAD *(ulazi u sastav preparata RESPIRO 30)..

CENOVNIK

50 mL – 600,00 RSD (5e);  100 mL – 1200,00 RSD (10e), MATIČNA TINKTURA, hidroetanolni tečni ekstrakt svežeg cveta DER 1:2.

Trifolium pratense (Fabaceae) REDOSLED AKTIVNOSTI po broju jedinjenja

Common names: Red Clover; Purple Clover; Peavine Clover; Cowgrass How used GRAS

Activities: 746 Chemicals w/Activities: 202l Chemicals: 413

Pesticide, Cancer-Preventive, Antioxidant, Fungicide, Antibacterial, Antiinflammatory, Flavor, Antispasmodic, Antiseptic, Antitumor, Antimutagenic, Antiviral, Analgesic, Hypotensive, Hypocholesterolemic, Allergenic, Insectifuge, Aldose-Reductase-Inhibitor, Antiulcer, Antidiabetic, Diuretic, Antiradicular, Hepatoprotective, Vasodilator, Sedative, Nematicide, Antiarthritic, Estrogenic, Perfumery, Antiosteoporotic, Immunostimulant, Hypoglycemic, Cardioprotective, Antifeedant, Antiaggregant, Anticataract, Irritant, Antihistaminic, Immunomodulator, Antiatherosclerotic, Antidepressant, Antihepatotoxic, Allelochemic, Antiedemic, Candidicide, Antileukemic, Anticancer, Antiherpetic, Apoptotic, Calcium-Antagonist, Cytotoxic, Antirheumatic, Antiprostatitic, Quinone-Reductase-Inducer, Antihypertensive, Essential, Antiparkinsonian, Antiasthmatic, Anxiolytic, ….

Reference:

Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

Planta Medica, 57: A43, 1991.

Aloe Research Council – Duke writeup of non-peer reviewd book by Coats and draft by Henry

Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.

Economic & Medicinal Plant Research, 6: 235.

Martindale’s 29th

Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.

Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp.

Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994.

Merck 11th Edition

Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X – The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95

Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.

Economic & Medicinal Plant Research, 5: 333.

Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253.

Williamson, E. M. and Evans, F. J., Potter’s New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.

Journal of Medicinal Food 2: 163.1999.

Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.

Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.

Hutchings, A, Scott, AH, Lewis, G, and Cunningham, A. 1996. Zulu Medicinal Plants. An inventory. University of Natal Press, Pietermaritzburg. 450 pp.

Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp.

Upotreba crvene deteline (Trifolium pratense L.) sa referencama, folk.

Trifolium pratense (Fabaceae) Common names: Tume-Ku; Trebol Rojo; Red Clover; Nafal; Kirmizi Yonca; Bersim Ahmar; Clover,Red; Trebo; Peavine Clover; Cowgrass; Purple Clover.

Data by Dr. Dzejms A. Djuk (Dr. James A. Duke)

TINKTURA OD CRVENE DJETELINE

TRIFOLIUM PRATENSE spag.Zimpel Urtinktur

Phytother Res. 2007 Feb;21(2):130-4.

Effects of phytoestrogenic isoflavones from red clover (Trifolium pratense L.) on experimental osteoporosis.

Occhiuto F, Pasquale RD, Guglielmo G, Palumbo DR, Zangla G, Samperi S, Renzo A, Circosta C.

Abstract

The most common type of osteoporosis is bone loss associated with ovarian hormone deficiency at menopause. There is evidence that diets which contain high levels of phytoestrogenic isoflavones are associated with a low incidence of osteoporosis and menopausal symptoms.

Plant extracts, which contain high levels of isoflavones, such as Red clover (Trifolium pratense L.), have been used to reduce menopausal symptoms. The objective of this study was to evaluate the preventive effects of Red clover total isoflavones on the progression of bone loss induced by estrogens deficiency (ovariectomy) in rats. Bilateral ovariectomy was performed on female Wistar rats. One week after the operation the rats were treated with an oral dose of 20 and 40 mg of total isoflavones daily for 14 weeks. The results from this study showed that the ovariectomy reduced bone mineral content, femoral weight, femoral density, mechanical strength of the tibia and increased the levels of bone specific alkaline phosphatase in the serum and the number of osteoclasts in the femur sections compared with sham operated controls.

Treatment with isoflavones significantly increased bone mineral content, mechanical strength of the tibia, femoral weight, femoral density and prevented the rise of serum alkaline phosphatase levels. In addition, the treatment with isoflavones significantly reduced the number of osteoclasts compared with the ovariectomized control rats. These findings suggest that Red clover isoflavones are effective in reducing bone loss induced by ovariectomy, probably by reducing of the bone turnover via inhibition of bone resorption.

Copyright (c) 2006 John Wiley & Sons, Ltd.

German Commission D Monographs (Preparation)