Preparati

BILJNI PREPARATI KOPRIVE:

TINKTURA – KOPRIVA HSS, hidroetanolni tečni ekstrakt sušenih delova biljke, DER 1:5 i 

MATIČNA TINKTURA – KOPRIVA TM, hidroetanolni tečni ekstrakt svežih delova samonikle biljke DER 1:1 (Ph. Fra.).

Urticae Tinctura DER 1:5,

Urticae herbae, folii, radicis recentis extractum ethanolicum liquidum DER 1:1 (Ph. Fra.),

Urticae folii recentis extractum ethanolicum liquidum DER 1:1 (Ph. Fra.),

Urticae radicis recentis extractum ethanolicum liquidum DER 1:1.

namenjeni pušačima, kod bolesti zavisnosti, zloupotrebe alkohola, lekova, nedovoljne fizičke aktivnosti, gojaznosti, ishrane tipa fast food i junk food, … kod infekcija urinarnog trakta,  osobama (muškarcima) preko 50 godina starosti. Protektor prostate.

ATC:

G04CX – ostali urologici.

– diuretik,

– antireumatik,

– detoksikant,

– nutritivni tonik.

U skladu sa:

Based on Article 16d(1), Article 16f and Article 16h of Directive 2001/83/EC as amended (traditional use) DIRECTIVE 2004/24/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 31 March 2004.

Eu. Ph. 8  01.07.2015. monografijom: 1897 (folium), 2538 (radix), 2030 Urtica dioica ad praeparationes homoeopathicas

EMA/HMPC/461156/2008, European Medicines Agency (EMA)/ Committee on Herbal Medicinal Products (HMPC) 24.09.2012.: Assessment report on Urtica dioica L., Urtica urens L., their hybrids or their mixtures, radix

EMEA/HMPC/168380/2006, European Medicines Agency (EMA)/ Committee on Herbal Medicinal Products (HMPC), London, 4 September: Assessment report on Urtica dioica L., and Urtica urens L., herba

EMA/HMPC/508013/2007, European Medicines Agency (EMA)/ Committee on Herbal Medicinal Products (HMPC), London, 14 January 2010: Assessment report on Urtica dioica L., Urtica urens L., folium 

Fr. Ph. 01.07.2015. ANSM: Urtica dioica ad praeparationes homoeopathicas

(Urtica dioica pour préparations homéopathiques)

Pharmacopée française 1989: Urtica urens pour préparations homéopathiques

a) Urtica dioica, folium (Nettle fresh, before flowering, top aerial part/ 3 pairs of leaves),

b) Urtica dioica, radix (Nettle fresh, after vegetation underground part),

c) Urtica dioica, herba (Nettle fresh, at flowering, whole plant).

Biljni preparati u tečnom obliku (nerazblaženi ili razblaženi) za oralnu i lokalnu upotrebu.

Sastav:

a) tečni ekstrakt (DER 1:1), ekstrakcioni rastvarač etanol 51% (v/v),

Urtica dioica L., sadrži 249 *(320) istraženih hemijskih jedinjenja koja ispoljavaju 742 *(817) dejstava *(podaci ažurirani septembra 2016.).

Sadržaj:

a) minimalno 0,04% m/m, ukupnih flavonol glikozida – rutinozida (flavonol glycoside – rutinosides), izraženih kao kaempferol-3-O-rutinozid () (MF: C₂₇H₃₀O₁₅, MW: 594,5181 g/mol⁻¹),

b) u većoj koncentraciji sadrži acetofenon, acetilholin, aglutinine, alkaloide, astragalin, buternu, kafeinsku, ugljenu, hlorogenu, mravlju, hininsku, kumaričnu, palmitinsku, pantotensku, ćilibarnu, linolnu i linolensku kiselinu, holin, folacin, friedelins, histamin, kaemferole, koproporfirine, lektine, lecitin, lignine i lignane, neoolivil, kvercetin, skopoletin, secoisolariciresinol, serotonin, sitosterole, stigmasterol, terpena, broma, violaksantina, flavonoide, kalcijuma, magnezijuma, kalaja, gvožđa, daukasterol, sumpora, …

c) više od svih biljaka sadrži hlorofila, fluora, silicijuma, kaempferol-3-O-rutinozida, …

Indikacije:

Biljni preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva.

Upotreba kod urogenitalnih, gastrointestinalnih, kožnih, endokrinih i neuroloških tegoba, imunostimulator.

Efikasno čisti krv, bubrege, jetru, slezinu, pankreas od toksičnih materija.

Dr. Džems Djuk (Dr. James Duke) u Handbook of Medicinal Herbs, 2nd Ed. (2002). CRC Press, navodi sledeće:

– ima jako dejstvo kod:

peska i kamena bubrega i bešike, dizurije, prostatitisa, reumatizma, litijaze, infekcija urinarnog trakta (UTI), polenske groznice, benigne hiperplazije prostate (BPH- Benign prostatic hyperplasia-N40), holangitisa (K83.9)

– delotvoran kod:

adenoma, alergija, anemije, artroza, astme, virusnih, gljivičnih i bakterijskih infekcija (Escherichia), krvarenja, bronhitisa, ujeda insekata, opekotina,  Ca. (dojke, uva, pluća, usta, slezine, želuca, materice), konvulzija, hronične venske insuficijencije (CVI), dermatitisa, dijareje i dizenterije, epistaksije, groznice, strume, gihta, HTA, HIV-a, hiperglikemije i hipoglikemije, infekcija i inflamacija, mikoza, miokardiopatije, nokturuje, osteoartroza, polaksiurije, rinitisa, išijasa, šigeloza, otoka- edema, TB, urtikarije, polenske groznice, …

 – u narodnoj medicini kod:

akni, adenopatije, alopecije, amenoreje, ataksije, kaheksije, kalkuloza, karcinoma, katara, holangitis, holecistitisa, kolere, kolika, kolitisa, kongestije, konstipacije, grčeva, cistitisa, peruti, dijabetesa, hidropsije, dismenoreje, dispepsije, ekcema, edema, endotelioma, enteritisa, epitelioma, erizipela, eritema, egzantema, gripa, gastritisa, gonoreje, glavobolje, hematurije, hemoptizije, hemoroida, hepatitisa, Herpesa, osipa, svraba, žutice, letargije, leukoreje, malarije, malarične groznice, melene, menoragije, mioza, nefritisa,  neuralgija, otitisa, paraliza, parotitisa,  pertusisa, faringitisa, pleuritisa, polipa, trudnoće, sarkoma, grlobolje, splenoza, uganuća, uboda, bolova u stomaku, stomatitisa, tendinitis, Tu., uremije, uteritisa, vaginitisa, veneričnih bolesti (VD), vertiga, infekcija crvima, rana, …

– spoljašnja primena kod:

hemoroida, povreda kože, rana, opekotina i oparotina, krvarenja iz nosa, peruti, …

 – upotrebljava se kao:

jak antiprostatik, diuretik, zatim kao analgetik, anestetik, anti-adrenalin, antialergik, antiartritik, antibakterik, anti-Ca, antikonvulzant, antiedemik, antieksudativ, antihistaminik, anti-HIV, antiinflamatik, antileukotriene antipiretik, antireumatik, antiseptik, antivirotik, akvaretik, adstrigent, bradikardik, CNS-depresant, inhibitor aromataze, ciklooksigenaze, elastaze, 5-LOX (5-lipoksigenaze), citotoksik, fungicid, hematogenik, hemostatik, histaminik, hipoglikemik i hiperglikemik, hipotenziv, Inteferonigenic pankreatonik, uterotonik, u tradicionalnoj medicini kao antiastmatik, antihemoragik, antihidrotik, antispazmodik, anti-Tu, afrodizijak, biter, Bleeding CVI depurativ, emenagog, ekspektorans, laktagog, laksativ, litolitik, mitogenik, miorelaksant, rubefacient, tonik, vazokonstriktor, vermifug, vulnerar, …

Monografija nemačke E komisije (Commission E Monographs), terapijski vodič za biljne lekove, preporučuje Urtica dioica za tretman inflamacija (unutrašnja i spoljašnja upotreba), i urinarnih infekcija zahvaljujući svojim diuretičkim dejstvima.

Doziranje i način primene:

2 mL (80 kapi) podeljeno u 2 do 4 doze.

Biljni preparat KOPRIVA HSS i TM:

pojedinačna doza: 0,5-1 mL, preporučena dnevna doza (PDD): 2 mL.

Oralna (sat vremena pre obroka) i lokalna primena.

Upotreba na koži: aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja.

Napraviti pauzu posle 4 nedelje neprekidne upotrebe.

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze.

Kontraindikacije:

preosetljivost na aktivne supstance,

preosetljivost na biljke porodice (genus Urtica, family Urticaceae).

Osim mogućih sporednih dejstava koja se mogu javiti prilikom korišćenja ove biljke, mnogo ozbiljniji simptomi se mogu javiti ako se uzima sa drugim lekovima. Ako uzimate neke lekove za povišeni krvni pritisak ili trombozu, upotreba koprive može uticati na zgušnjavanje krvi i sniziti vam krvni pritisak, a time, u zavisnosti od vrste lekova, ili poboljšati ili smanjiti njihovo dejstvo.
Koren od koprive takođe može pojačati efekte diuretika, nesteroidnih antibiotika i lekova za dijabetes. Organizam takođe može imati poteškoća da izbaci litijum zbog diuretskih efekata ove biljke.
I na kraju, koren koprive može uticati na menstrualni ciklus kod žena i eventualno rezultirati spontanim pobačajem. Zato se upotreba korena koprive ne preporučuje trudnicama.

Čuvanje:

na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju,  u dobro zatvorenoj originalnoj ambalaži.

Rok upotrebe:

5 godina, posle prvog otvaranja 6 meseci.

Pakovanje:

50 mL i 100 mL, farmaceutske braon bočice standarno, 250 mL, 500 mL, 1L i 5 L na zahtev.

Nutritivne informacije:

KOPRIVA HSS i TM:

energetska vrednost u 100 mL: 1172 kJ/ 280 kcal,

u preporučenoj dnevnoj dozi (PDD) 2 mL: 23,45kJ/ 5,6 kcal,

suve materije (DR) više od 1,1% dioica/ 1,2% urens  (Fr. Ph.), 1,6% dioica, 1,5% urens (HAB), 0,930 – 0,950.

Bez konzervanasa, proteina, masti i ugljenih hidrata.

KOPRIVA HSS i TM su rukom rađeni proizvodi. 

Analizu na teške metale, pesticide i mikrobiološku ispravnost preparata broj 4603120601 od 29.03.2016. godine izvršila ANAHEM LABORATORIJA BEOGRAD, u okviru preparata RESPIRO 30.     Ana1   Ana2

CENOVNIK

LIST

MATIČNA TINKTURA, KOPRIVA LIST TM, hidroetanolni tečni ekstrakt svežih delova samonikle biljke DER 1:1, 50 mL/  600,00 RSD; 100 mL/ 1200,00;

KOREN

MATIČNA TINKTURA, KOPRIVA KOREN TM, hidroetanolni tečni ekstrakt svežih delova samonikle biljke DER 1:1, 50 mL/  720,00 RSD; 100 mL/ 1440,00; 

Podaci ažurirani januara 2017. Pogledati i ostale podatke na:

http://www.biljni-preparati.com/preparati/kopriva-urtica-dioica/#top       

Urtica dioica (Urticaceae) Common name Nettle,Common

Use

ache, ache (back), alopecia, anodyne, asthma, astringent, ataxia (locomotor), bactericide, blood, bronchitis, bruise, burn,  cancer, catarrh, chest, cholecystitis, cholengitis, constipation, cosmetic, cough, counterirritant, dandruff, depurative, diuretic, dropsy, dyspnea, emmenagogue, epilepsy, epistaxis, evil eye, fit, gout, hair-tonic, hematemesis, hematoptysis, hemoptysis, hemorrhage, hemostat, homeopathy, insanity, massage, menorrhagia, metrorrhagia, paralysis, parturition, purgative, rheumatism, shampoo, shigellosis, sore, sprain, stimulant, stomachic, suppository, swelling, tantrum, tea, tonic, tumor, urticaria, vasoconstrictor, vermifuge, vermifuge, wound,

TOP Activity (spisak – redosled po broju jedinjenja):

Cancer-preventive, antioxidant, antibacterial, antitumor, antiinflammatory, antimutagenic, Hepatoprotective, antiviral, antiseptic, fungicide, hypocholesterolemic, hypotensive, antidiabetic, antiulcer, antiradicular, aldose-reductase-inhibitor, diuretic, antispasmodic, antihepatotoxic,choleretic, analgesic, allergenic, antiarthritic, flavor, antiatherosclerotic, cardioprotective, hypoglycemic, anticancer, vasodilator, antitumor-promoter, antiherpetic, immunomodulator, immunostimulant, antiaggregant, antiHIV, anticataract, antileukemic, antihistaminic, antidepressant

reference:

Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

Economic & Medicinal Plant Research, 6 235.

Fitoterapia No.5-1990.

Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.

Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X – The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95

Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4) 1049-1052, 1990.

Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388

Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.

Aloe Research Council – Duke writeup of non-peer reviewd book by Coats and draft by Henry

Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215.

Amoros, M., Simoes, C.M.O., Girre, L., et al. Synergistic Effect Of Flavones And Flavonols Against Herpes Simplex Virus Type 1 In Cell Culture. Comparison With The Antiviral Activity Of Propolis. J. of Natural Products 55(12):1732-1740, 1992.

Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp.

Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp

Podaci:  Dr. Dzejms A. Djuk (Dr. James A. Duke), Handbook of Medicinal Herbs, 2nd Ed. (2002). CRC Press,

Tinktura koprive 1:5 Florida herbal pharmacy

TINKTURA OD KOPRIVE

URTICA DIOICA Urtinktur  DHU

Nettle Extract – mountain rose herbs

Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study.

Safarinejad .

Abstract

PURPOSE:

To determine the effects of therapy with Urtica dioica for symptomatic relief of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).

MATERIAL AND METHODS:

A 6-month, double-blind, placebo-controlled, randomized, partial crossover, comparative trial of Urtica dioica with placebo in 620 patients was conducted. Patients were evaluated using the International Prostate Symptom Score (IPSS), the maximum urinary flow rate (Qmax), postvoid residual urine volume (PVR), Serum Prostatic- Specific Antigen (PSA), testosterone levels, and prostate size. At the end of 6-month trial, unblinding revealed that patients who initially received the placebo were switched to Urtica dioica. Both groups continued the medication up to 18 months.

RESULTS:

558 patients (90%) completed the study (287/305, 91% in the Urtica dioica group, and 271/315, 86% in the placebo group). By intention- to-treat analysis, at the end of 6-month trial, 232 (81%) of 287 patients in the Urtica dioica group reported improved LUTS compared with 43 (16%) of 271 patients in the placebo group (P < 0.001). Both IPSS and Qmax showed greater improvement with drug than with placebo. The IPSS went from 19.8 down to 11.8 with Urtica dioica and from 19.2 to 17.7 with placebo (P = 0.002). Peak flow rates improved by 3.4 mL/s for placebo recipients and by 8.2 mL/s for treated patients (P < 0.05). In Urtica dioica group, PVR decreased from an initial value of 73 to 36 mL (P < 0.05). No appreciable change was seen in the placebo group. Serum PSA and testosterone levels were unchanged in both groups. A modest decrease in prostate size as measured by transrectal ultrasonography (TRUS) was seen in Urtica dioica group (from 40.1 cc initially to 36.3 cc; P < 0.001). There was no change in the prostate volume at the end of study with placebo. At 18-month follow-up, only patients who continued therapy, had a favorable treatment variables value. No side effects were identified in either group.

CONCLUSION:

In the present study, Urtica dioica have beneficial effects in the treatment of symptomatic BPH. Further clinical trials should be conducted to confirm these results before concluding that Urtica dioica is effective.

German Commission E Monographs (Phytotherapy)

German Commission D Monographs (Preparation)