Zlatnica (Solidago virgaurea/ gigantea L.)

Zlatnica (Solidago virgaurea/ gigantea L.)

BILJNI PREPARATI ZLATNICE:

TINKTURA ZLATNICA HSS I 

MATIČNA TINKTURA, HIDROETANOLNI EKSTRAKT SVEŽE BILJKE ZLATNICA TM  

Tinctura Solidaginis 1:5

Solidaginis virgaureae herbae recentis extractum ethanolicum liquidum

namenjen prevenciji bubrežnih kamenaca, urinarnih infekcija (bubrega, urinarnih kanala, bešike), kao pomoć kod peska i kamena bubrega i bešike,  kalkuloza, inflamacija, infekcija urinarnog trakta (UTI), zastoja tečnosti, …

BILJNI PREPARATI ZLATNICE:

TINKTURA ZLATNICA HSS I 

MATIČNA TINKTURA, HIDROETANOLNI EKSTRAKT SVEŽE BILJKE ZLATNICA TM  

Tinctura Solidaginis 1:5

Solidaginis virgaureae herbae recentis extractum ethanolicum liquidum

 

ATC:

antioksidant, analgetik, spazmolitik, antimikotik (fungicid), antikancerogenik,

– antiinflamatik, – diuretik, –  antibakterik, – imunostimulator, 

 

U skladu sa:

Eu. Ph. 01.07.2015. monografijom: 1892 Solidaginis herba, 1893 Solidaginis virgaureae herba

European Medicines Agency EMEA/ HMPC 04.09.2008. Doc. Ref. EMEA/HMPC/285758/2007: COMMUNITY HERBAL MONOGRAPH ON SOLIDAGO VIRGAUREA L., HERBA

European Medicines Agency EMEA/ HMPC 04.09.2008. Doc. Ref. EMEA/HMPC/285759/2007: Assessment report on Solidago virgaurea L., herba

Fr. Ph. ANSM 2009 Solidago virgaurea ad praeparationes homoeopathicas (SOLIDAGE VERGE D’OR POUR PRÉPARATIONS HOMÉOPATHIQUES) method 1.1.10 (2371).

 

Biljni preparati u tečnom obliku (nerazblaženi ili razblaženi) za oralnu i lokalnu upotrebu.

 

a) Solidago gigantea/virgaurea L., summitus (Goldenrod fresh inflorescence/ fresh blooming heads).

 

Sastav:

a) tečni ekstrakt (DER 1:2), ekstrakcioni rastvarač etanol 65% v/v (HAB), 50%-65% v/v (Ph.Fr.).

 

Solidago gigantea/virgaurea L., sadrži 35 (*38)  istraženih hemijskih jedinjenja koja ispoljavaju 296 (*314) dejstava (*podaci ažurirani jula 2016).

 

Sadržaj:

flavonoidi, triterpen saponini, esencijalna ulja, diterpeni;

a) minimalno 0,02% m/m (0,5-1,5% dried drug), ukupnih flavonoida, izraženih kao hiperozid (hyperoside) (MF: C21H20O12, MW: 464,3763 /mol−1),

b) u većoj koncentraciji sadrži kofeinsku kiselinu (najviše posle Ipomoea purga), ferulinsku, protokatehuinsku, siringinsku, vanilinsku kiselinu,

c) više od svih biljaka sadrži solidagolakton (Solidagolactone), sinapinsku kiselinu, gigantea saponine, …

 

Indikacije:

biljni preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva.

Upotreba kod urogenitalnih tegoba. Efektivno deluje na Candida spp.

 

Ima jako dejstvo kod:

peska i kamena bubrega i bešike,  kalkuloza, inflamacija, infekcija urinarnog trakta (UTI), zastoja tečnosti, …

 

Delotvoran kod:

krvarenja, Ca., kandidijaza, katara, grčeva, cistitisa, dijareje, dizenterije, otoka-edema, fungusa, HTA, imunodepresije, infekcija, insomnije, mikoza, nefroza,  neuroza, pertusisa, faringitisa, upale grla, stomatitisa, Tu., rana, gljivičnih infekcija, pijelonefritisa, hronične bubrežne insuficijencije, zadržavanja tečnosti,

 

U narodnoj medicini kod:

albuminurije, amenoreje, artroza, astme, atonije, bronhitisa, Ca. dojke, holecistitisa, kolere, konstipacije, dijabetesa, difterije, hidropsije, dismenoreje, disurije, ekcema, groznice, gripa, gasova, gastritisa, gihta,  glavobolje, hemoroida, hepatomegalije, hepatitisa, malarije, mastitisa, malih boginja, menoragije, fosfaturije, ftizije-sušice, reumatizma, skrofula, povreda, spazma, splenoze,  tenezmusa, zubobolje, TB, uremije, bakterijskih infekcija, peska i kamena u bubregu,

 

Spoljašnja primena kod:

 

Upotrebljava se kao:

jak bubrežni tonik,  antispazmatik, antiinflamatik, diuretik, zatim kao alergenik, analgetik, antiedemik, antieksudativ, antilitolitik, antiseptik, antispazmodik, antiTu, akvaretik, adstrigent, kandidacid, fungicid, hemostat, hipotenziv, imunostimulator, litolitik, sedativ, spermicid, vulnerar, u tradicionalnoj medicini kao antipiretik, karminativ, cikatrizant, dekoagulant, dijaforetik, digestiv, ekspektorant, laksativ, stimulant, tonikum, urinarni antiseptik, dezinfekcijens, antimikotik, aromatik i digestiv,  stiptik, …

 

Monografija nemačke E komisije (Commission E Monographs), terapijski vodič za biljne lekove, preporučuje Solidago gigantea/ virgaurea kao diuretik i za tretman urinarnih infekcija (UTI).

 

Doziranje i način primene:

2 mL (80 kapi) podeljeno u 2 do 4 doze.

Biljni preparati ZLATNICA HSS i TM:

pojedinačna doza: 0,5-1 mL,

preporučena dnevna doza (PDD): 2 mL.

Oralna (sat vremena pre obroka) sa dosta tečnosti i lokalna primena.

Upotreba na koži: aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja.

 

Napraviti pauzu posle 4 nedelje neprekidne upotrebe.

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze.

 

Potrebna je pažljiva upotreba kod pacijenata sa hroničnom bubrežnom insuficijencijom.

 

Kontraindikacije:

preosetljivost na aktivne supstance,

preosetljivost na biljke porodice (genus Solidago, family Asteraceae).

 

Čuvanje:

na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju, u dobro zatvorenoj originalnoj ambalaži.

 

Rok upotrebe:

5 godina, posle prvog otvaranja 6 meseci.

 

Pakovanje:

50 mL i 100 mL, farmaceutske braon bočice standarno, 250 mL, 500 mL, 1000 mL i 5000 mL na zahtev.

 

Nutritivne informacije:

ZLATNICA HSS i TM:

energetska vrednost u 100 mL: 1504 kJ/ 360 kcal,

u preporučenoj dnevnoj dozi (PDD) 2 mL: 30 kJ/ 7,17 kcal,

suve materije (DR) više od 1,50% (Ph.Fr. 2009), 2,50% (DAB/ GHP2009), RD 0,900-0,915.

 

Bez konzervanasa, proteina, masti i ugljenih hidrata.

ZLATNICA HSS i TM su rukom rađeni proizvodi. 

Analizu na teške metale, pesticide i mikrobiološku ispravnost preparata broj 4603120601 od 29.03.2016. godine izvršila ANAHEM LABORATORIJA BEOGRAD, u sklopu preparata RESPIRO 30. (rezultat analize strana 1 strana 2)

CENOVNIK

HSS RSD 500/ 50 mL, 1000/ 100 mL TINKTURA, DER 1:5,

TM 600/ 50 mL, 1200/ 100 mL MATIČNA TINKTURA, HIDROETANOLNI EKSTRAKT SVEŽE BILJKE, DER 1:2.

Upotreba zlatnice (Solidago virgaurea L.) sa referencama

Solidago virgaurea (Asteraceae) Common name European Goldenrod

astma
adstrigent Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
karminativ Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
cikatrizant
dijareja
digestiv Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
diuretik Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
hidropsija
dizenterija
ekcem
edem
groznica
lithontriptik
nefritis
nervin Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
pertusis
renitis
reumatizam
traume
stimulant Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
sudorifik
čaj Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
tonik Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
Tu Hartwell, J.L. 1967-71. Plants used against cancer. A survey. Lloydia 30-34.
vulnerar Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
povrede Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.

Data by National Agricultural Library.

Goldenrod (Solidago virgaurea)

Synonyms / Common Names / Related Terms

Aaron’s rod, acetylene, astragalin, beta-amyrin acetate, beta-dictyopterol, blue mountain tea, Canadian goldenrod, cinnamate, clerdane diterpene, early goldenrod, echte guldenroede (Dutch), elongatolide C, elongatolide E, European goldenrod, flavonoid, golden rod, goldrute, Goldrutenkraut (German), hydroxybenzoates, hyperoside, inulin, isoquercetin, kaempferol, kaempferol-3-O-rutinoside, leicarposide, liberty tea, liu chi nu ts’ao, methyl 3,5-di-O-caffeoyl quinate, nicotiflorin, oleanolic acid, phenolic acid, phenolic glucoside, polygalic acid, polysaccharide, quercetin, rutin, saponin, solidago, Solidago canadenis,Solidago gigantea, Solidago nemoralisSolidago odora, Solidago serotinaSolildago spathulataSolidago virgaurea, solidagolactone, tannin, trans-phytol, vara de oro, wound weed, wound wort, Yahudiotu, yellow weed.

Combination product examples: Phytodolor® (aspen, common ash, goldenrod).

Note: Avoid confusion with mullein, which is also referred to as goldenrod and with rayless goldenrod which is a species from the same family as goldenrod

Note: This monograph primarily discusses Solidago virgaurea.

 

Mechanism of Action

Pharmacology:

  • Constituents: Goldenrod contains trans-phytol, ent-germacra-4(15),5,10(14)-trien-1alpha-ol, beta-amyrin acetate, ent-germacra-4(15),5,10(14)-trien-1beta-ol, beta-dictyopterol, oleanolic acid, kaempferol, kaempferol-3-O-rutinoside, methyl 3,5-di-O-caffeoyl quinate, and 3,5-di-O-caffeoyl quinic acid.20 The aerial parts of Solidago virgaurea contain virgaureasaponin 322 and acylated bisdesmosidic triterpenoid glycosides of polygalacic acid (2 beta, 3 beta, 16 alpha, 23-tetrahydroxyolean-12-en-28-oic acid)23.
  • Unsupported sources claim that the primary chemical constituents of goldenrod include saponins (based on polygalic acid), clerdane diterpenes (including elongatolide C, elongatolide E, and solidagolactones I-VII ), phenolic glucosides (leicarposide), flavonoids (astragalin, hyperoside, isoquercetin, nicotiflorin, quercetin, and rutin), inulin, essential oil, tannins, acetylenes, cinnamates, hydroxybenzoates, polysaccharides, and phenolic acids.
  • The closely related Solidago canadensis contains both enantiomers of germacrene D and lesser amounts of germacrene A, alpha-humulene, and beta-caryophyllene24, and 2′-hydroxy-4′,6′-di-O-beta-d-glucopyranosyl-butyrrophenone25.
  • Analgesic effects: In an in vitro study, Solidago virgaurea extract had biological activity with receptors implicated in the mediation of pain11
  • Antifungal effects: In an in vitro study, triterpenoid glycosides obtained from Solidago virgaurea L. inhibited the growth of human-pathogenic yeasts (Candida and Cryptococcus species).12,13
  • Anti-inflammatory effects: A hydro-alcoholic extract of goldenrod has shown anti-inflammatory and analgesic effects in inflammation models.6 In an animal study, a 46% ethanolic extract from goldenrod significantly reduced (p<0.05) the intensity of inflammation in Freund’s adjuvant-induced arthritis of rat paw.7 In an in vitro study, Solidago virgaurea extract inhibited dihydrofolate reductase with an I50 value of 0.6% (volume/volume).21
  • Leiocarposide, a constituent of goldenrod, showed anti-inflammatory and analgesic effects after subcutaneous administration to rats and mice.8
  • Antimicrobial effects: In an in vitro study, extracts of Solidago virgaurea and Solidago graminifolia had amebostatic activity against pathogenic Acanthamoeba spp.14
  • Antitumor effectsIn vitro studies have shown immunomodulatory effects on murine spleen and thymus cells and on human mononuclear cells.9 Virgaureasaponin E, a constituent found in goldenrod, has shown in vivo antitumor effects in mice.10 In an in vitro study, saponins from Solidago virgaurea L. showed cytotoxicity in YAC-1- and P-815-tumor cells.26 An active, water soluble component from Solidago virgaurea leaves exhibited strong cytotoxic activities on various tumor cell lines, including human prostate (PC3), breast (MDA435), melanoma (C8161), and small cell lung carcinoma (H520).27 These results were supported in vivo in a rat prostate cancer model with intraperitoneal and subcutaneous administration of a Solidago virgaurea fraction.
  • Cardiovascular effects: In animal studies goldenrod extract had hypotensive effects.17,18
  • Diuretic effects: In animal studies, goldenrod extract containing 0.3% flavonoids has shown a significant diuretic effect in rats.1 Another rat study using oral Solidago virgaurea flavonoids also showed a 57-88% increase in overnight diuresis; overnight excretion of potassium and sodium decreased and calcium excretion increased.19 Leiocarposide, a constituent of goldenrod has been shown to have a diuretic effect after oral or intra-peritoneal administration to rats and also inhibited growth of implanted human urinary calculi in the rat bladder.2,3,4,5
  • Muscular contraction activity: In one in vitro study, Solidaginis virgaurea extract inhibited carbachol-induced muscarinic receptor-mediated contraction of rat and human bladder tissues.15 In an animal study, a 60% hydroethanolic extract from goldenrod inhibited acetycholine-induced contractions of guinea pig ileum.16
  • Neurological effects: In animal studies goldenrod had sedative effects.17,18

 

Pharmacodynamics/Kinetics:

  • Animal studies have shown that leiocarposide, a constituent of goldenrod, is excreted mostly unchanged in the urine after parenteral administration.28 Leiocarposide is also broken down in the colon of rats.

 

References

  1. Schilcher H and Rau H. Nachweis der aquaretischen Wirkung von Birkenblatter- und Goldrutenkrautauszugen im Tierversuch. Urologe B1988;28:274-280.
  2. Budzianowski J. Die urologische Wirkung des Leiocarposids.Drogenreport 1999;12:20-21.
  3. Chodera, A., Dabrowska, K., Bobkiewicz-Kozlowska, T., Tkaczyk, J., Skrzypczak, L., and Budzianowski, J. [Effect of leiocarposide on experimental urinary calculi in rats]. Acta Pol Pharm1988;45(2):181-186. 3239428
  4. Chodera, A., Dabrowska, K., Skrzypczak, L., and Budzianowski, J. [Further studies on the diuretic effect of leiocarposide]. Acta Pol Pharm1986;43(5):499-503. 3565048
  5. Chodera, A., Dabrowska, K., Senczuk, M., Wasik-Olejnik, A., Skrzypczak, L., Budzianowski, J., and Ellnain-Wojtaszek, M. [Diuretic effect of the glycoside from a plant of the Solidago L. genus]. Acta Pol Pharm1985;42(2):199-204. 4083055
  6. Okpanyi, S. N., Schirpke-von Paczensky, R., and Dickson, D. [Anti-inflammatory, analgesic and antipyretic effect of various plant extracts and their combinations in an animal model]. Arzneimittelforschung1989;39(6):698-703. 2476136
  7. el Ghazaly, M., Khayyal, M. T., Okpanyi, S. N., and Arens-Corell, M. Study of the anti-inflammatory activity of Populus tremula, Solidago virgaurea and Fraxinus excelsior. Arzneimittelforschung1992;42(3):333-336. 1497695
  8. Metzner, J., Hirschelmann, R., and Hiller, K. [Antiphlogistic and analgesic effects of leiocarposide, a phenolic bisglucoside of Solidago virgaurea L.]. Pharmazie1984;39(12):869-870. 6531401
  9. Plohmann, B., Bader, G., Hiller, K., and Franz, G. Immunomodulatory and antitumoral effects of triterpenoid saponins. Pharmazie1997;52(12):953-957. 9442560
  10. Plohmann B, Franz G, Bader G, and Hiller K. Immunomodulatorische und antitumorale Aktivitat von Triterpensaponined aus Solidago virgaureaDrogenreport 1999;12:29-30.
  11. Sampson, J. H., Phillipson, J. D., Bowery, N. G., O’Neill, M. J., Houston, J. G., and Lewis, J. A. Ethnomedicinally selected plants as sources of potential analgesic compounds: indication of in vitro biological activity in receptor binding assays. Phytother Res2000;14(1):24-29. 10641043
  12. Bader, G., Kulhanek, Y., and Ziegler-Bohme, H. [The antifungal action of polygalacic acid glycosides].Pharmazie 1990;45(8):618-620. 2080212
  13. Bader, G., Seibold, M., Tintelnot, K., and Hiller, K. Cytotoxicity of triterpenoid saponins. Part 2: Relationships between the structures of glycosides of polygalacic acid and their activities against pathogenic Candida species. Pharmazie2000;55(1):72-74. 10683877
  14. Derda, M., Hadas, E., Thiem, B., and Sulek, A. [Amebicidal plants extracts]. Wiad Parazytol2004;50(4):715-721. 16862806
  15. Borchert, V. E., Czyborra, P., Fetscher, C., Goepel, M., and Michel, M. C. Extracts from Rhois aromatica and Solidaginis virgaurea inhibit rat and human bladder contraction. Naunyn Schmiedebergs Arch Pharmacol2004;369(3):281-286. 14963639
  16. Westendorf, J. and Vahlensieck, W. [Spasmolytic and contractile effects of a combination product from plants on the smooth muscle of the guinea pigs]. Arzneimittelforschung 1981;31(1):40-43. 7194092
  17. Lasserre, B., Kaiser, R., Pham, Huu Chanh, Ifansyah, N., Gleye, J., and Moulis, C. Effects on rats of aqueous extracts of plants used in folk medicine as antihypertensive agents. Naturwissenschaften1983;70(2):95-96. 6843684
  18. Racz-Kotilla E and Racz G. Actiunea hipotensiva si sedative a extractelar de Solidago virgaureaProc Acad Sc Bucuresti, Note Botanice 1977;13:1-5.
  19. Chodera, A., Dabrowska, K., Sloderbach, A., Skrzypczak, L., and Budzianowski, J. [Effect of flavonoid fractions of Solidago virgaurea L on diuresis and levels of electrolytes]. Acta Pol Pharm1991;48(5-6):35-37. 1669338
  20. Choi, S. Z., Choi, S. U., and Lee, K. R. Phytochemical constituents of the aerial parts from Solidago virga-aurea var. gigantea. Arch Pharm Res2004;27(2):164-168. 15022716
  21. Strehl, E., Schneider, W., and Elstner, E. F. Inhibition of dihydrofolate reductase activity by alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea. Arzneimittelforschung1995;45(2):172-173. 7710442
  22. Bader, G., Wray, V., and Hiller, K. Virgaureasaponin 3, a 3,28-bisdesmosidic triterpenoid saponin from Solidago virgaurea. Phytochemistry 1992;31(2):621-623. 1367971
  23. Bader, G., Wray, V., and Hiller, K. The main saponins from the aerial parts and the roots of Solidago virgaurea subsp. virgaurea. Planta Med1995;61(2):158-161. 7753924
  24. Prosser, I., Phillips, A. L., Gittings, S., Lewis, M. J., Hooper, A. M., Pickett, J. A., and Beale, M. H. (+)-(10R)-Germacrene A synthase from goldenrod, Solidago canadensis; cDNA isolation, bacterial expression and functional analysis. Phytochemistry2002;60(7):691-702. 12127586
  25. Zhang, J., Zhang, X., Lei, G., Li, B., Chen, J., and Zhou, T. A new phenolic glycoside from the aerial parts of Solidago canadensis. Fitoterapia9-23-2006;17067755
  26. Bader, G., Plohmann, B., Hiller, K., and Franz, G. Cytotoxicity of triterpenoid saponins. Part 1: Activities against tumor cells in vitro and hemolytical index. Pharmazie1996;51(6):414-417. 8767852
  27. Gross, S. C., Goodarzi, G., Watabe, M., Bandyopadhyay, S., Pai, S. K., and Watabe, K. Antineoplastic activity of Solidago virgaurea on prostatic tumor cells in an SCID mouse model. Nutr Cancer2002;43(1):76-81. 12467138
  28. Fotsch, G., Pfeifer, S., Bartoszek, M., Franke, P., and Hiller, K. [Biotransformation of phenolglycosides leiocarposide and salicin]. Pharmazie 1989;44(8):555-558. 2594827

Izvor:  www.sigmaaldrich.com

German Commission E Monographs (Phytotherapy) 

List of German Commission E Monographs (Phytotherapy)

Goldenrod (Solidago) Published October 15, 1987; Revised March 13, 1990.

 

 German Commission D Monographs 

Monographie BGA/BfArM (Kommission D)

Solidago virgaurea ex herba Bundesanzeiger Nr. 199 a vom 20.10.1989

 

Die Phytotherapeutische Welt (1983)

Goldrutenkraut (Solidago gigantea AlT.) (Solidago virgaurea)

 












Pakovanje mL/ g:
 10 20 30 50 100 250 500 1000

Količina:
1 2 3 više 

 

 

 

vrh