Preparati

BILJNI PREPARATI  BURJANA:

BURJAN TM – MATIČNA TINKTURA – hidroetanolni tečni ekstrakt svežih delova biljke,

BURJAN OL – ULJANI MACERAT LISTOVA, uljani macerat svežih listova biljke.

ATC:

R05 – ekspektorans,

A06A – laksativ,

– dijaforetik, – diuretik, – supresor apetita.

U skladu sa:

1 – Based on Article 16d(1), Article 16f and Article 16h of Directive 2001/83/EC as amended (traditional use), DIRECTIVE 2004/24/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 31 March 2004.

2 – Eu. Ph. 2015  monografijom: 

3 – EMEA: Assessment report on Sambucus ebulus L., folium 

4 – EMEA: Assessment report on Sambucus ebulus L., fructus

5 – Fr. Ph. ANSM Sambucus ebulus ad praeparationes homoeopathicas

6 – HAB 34 Fructus Ebuli

7 – HPUS 88 Radix/rhizoma ebuli (Radix/ rhizoma Sambuci ebuli),

Biljni preparati u tečnom obliku (nerazblaženi ili razblaženi) za oralnu i lokalnu upotrebu.

a) Sambucus ebulus L., fructus (Dwarf elderberry fresh berry),

b) Sambucus ebulus L., folium (Dwarf elderberry fresh leaf),

c) Sambucus ebulus , radix (Dwarf elderberry fresh/ dried root).

Sastav:

a) tečni ekstrat (DER 1:2), ekstrakcioni rastvarač etanol 65% (v/v),

b) tečni ekstrat (DER 1:4), ekstrakcioni rastvarač maslinovo ulje.

Sambucus ebulus L., sadrži 197 hemijskih jedinjenja koja ispoljavaju 687 istraženih dejstava.

Sadržaj:

a) minimalno 0,05% m/m ukupnih flavonoida, izraženih kao rutin – rutin trihidrat (MF: C₂₇H₃₀O₁₆, MW: 610,6175 g/mol⁻¹; MF: C₂₇H₃₆O₁₉, MW: 664,56334 g/mol⁻¹),

b) u većoj koncentraciji sadrži flavonoide, fenole, steroide, tannine, glikozide, srčane glikozide, derivate kafeinske kiseline, ebulitine i isparljive materije,

c) više od svih biljaka sadrži ebulin.

Indikacije:

Biljni preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva.

Upotreba kod respiratornih i kožnih tegoba.

Dr. Džems Djuk (Dr. James Duke) u Handbook of Medicinal Herbs, 2nd Ed. (2002). CRC Press, navodi sledeće:

– ima jako dejstvo kod:

bronhitisa, nazeba, kašlja, groznice, artritisa, ….

– delotvoran kod:

zastoja tečnosti,  visokog krvnog pritiska, prehlada,  gihta, reumatizma, neuralgija, dispneje, gripa, inflamacija, influence, respiratornih infekcija, cistitisa, nefropatije, peska u UT, opstrukcije, regulisanju telesne težine (appetite suppressant),   …

– u narodnoj medicini kod:

artroza, angine, apendicitisa, artroza, ascita, astme, ekcema, edema, epilepsije, erizipela, egzantema, neuralgije, neuroza, nefroza, hematoma- modrica,  mialgije,  gasova, gastritisa, gihta, glavobolje, gojaznosti, groznice, grčeva, gonoreje, pada imuniteta, promuklosti, Ca.(dojke, jetre, kože, bubrega, prepucijuma, slezine, želudca, materice), kondiloma, konstipacije, kašlja, dermatoza, cistitisa, uteritisa, hidropsije, hidropsije,hepatitisa, induracije, laringitisa i faringitisa, otitisa, pneumonije, psorijaze, promuklosti, reumatizma, skleroza, splenoza, sifilisa, stomatitisa, škrofula, zubobolje, …

– spoljašnja primena kod:

ekcema,  šuge, bradavica, opekotina, dermatoza, antiseptik, antimikrobik, …kozmetik, repelent, za ispiranje grla, …

– upotrebljava se kao:

dijaforetik, diuretik, purgativ, antioksidant, antikancerogenik, antiflogistik, ekspektorant, hipotenziv, neuralgik, supresor apetita,  antireumatik, antiinflamatik, laksativ, alternativ, antipiretik, karminativ, depurativ, purgativ, tonik, emetik, stimulant, emolient, resolvent, holagog, homeopatik, …

Monografija nemačke E komisije (Commission E Monographs), terapijski vodič za biljne lekove, preporučuje Sambucus ebulus za kašalj, bronhitis, prehlade i groznicu.

Simptomi trovanja: krvava dijareja, cijanoza, vrtoglavica, glavobolja, krv u stolici, midrijaza, mučnina, bolovi u ustima i povraćanje.

Doziranje i način primene:

2 mL (80 kapi) podeljeno u 2 do 4 doze.

Biljni preparat BURJAN HSS, TM i OL:

pojedinačna doza: 0,5-1 mL, preporučena dnevna doza (PDD): 2 mL.

Oralna (sat vremena pre obroka) i lokalna primena.

Upotreba na koži: aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja.

Napraviti pauzu posle 4 nedelje neprekidne upotrebe.

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze.

VAŽNO: kod oralne upotrebe potrebno je neposredno pre upotrebe, a zbog eventualnih neželjenih efekata kod osetljivih osoba, izložiti preparate ključaloj vodi u vremenu od najmanje 5 minuta (radix ebuli elixata).

Kontraindikacije:

preosetljivost na aktivne supstance,

preosetljivost na biljke porodice (genus Sambucus, family Adoxaceae/ Caprifoliaceae).

Čuvanje:

na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju,  u dobro zatvorenoj originalnoj ambalaži.

Rok upotrebe:

5 godina, posle prvog otvaranja 6 meseci.

Pakovanje:

50 mL i 100 mL (1 3/4 fl oz i 3 1/2 fl oz), farmaceutske braon bočice standarno, 250m L, 500 mL, 1L i 5 L na zahtev.

Nutritivne informacije:

BURJAN HSS i TM:

a) energetska vrednost u 100 mL: 1504 kJ/ 360 kcal,

u preporučenoj dnevnoj dozi (PDD) 2 mL: 30kJ/ 7,17 kcal,

suve materije (DR) više od 1,7% (HAB 2000).

b) energetska vrednost u 100 mL: 1172 kJ/ 280kcal,

u preporučenoj dnevnoj dozi (PDD) 2 mL: 23,45kJ/ 5,6kcal;

suve materije (DR) više od 2,2% (Fr. Ph.).

BURJAN OL:
c) energetska vrednost u 100 mL: 3389 kJ/ 810kcal,
u preporučenoj dnevnoj dozi (PDD) 2 mL: 67,78kJ/ 16,2kcal,
masti (g) 91,6/ 1,83: zasićenih (g) 13,0/ 0,26; nezasićenih (g) 70/ 1,40; polunezasićenih (g) 8,6/ 0,17.

Bez konzervanasa, proteina, masti i ugljenih hidrata.

BURJAN HSS, TM i OL su rukom rađeni proizvodi. CENOVNIK

MATIČNA TINKTURA, BURJAN TM tečni hidroetanolni ekstrakt sveže biljke/ delova biljke..

50 mL – 600,00 RSD (5 evra); 100 mL – 1200,00 RSD (10 evra);

Više informacija na: http://www.biljni-preparati.com/preparati/sambucus-ebulus/

Sambucus ebulus (Caprifoliaceae)
Common names: Ine; Elderberry; Dwarf Elder; Yermurveri; Yezgo; Khaman Saghir

Use

alterative, diuretic, expectorant, poison, purgative,

aperient, diaphoretic, dropsy, laxative, sudorific, tea, Tumor(joint), Tumor(thigh)

Reference
Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
Al-Rawi, Ali. 1964. Medicinal Plants of Iraq. Tech. Bull. No. 15. Ministry of Agriculture, Directorate General of Agricultural Research Projects.
Lewis and Elvin-Lewis, Medical Botany, ca 1977
Font Query, P. 1979. Plantas Medicinales el Dioscorides Renovado. Editorial Labor, S.A. Barcelona. 5th Ed.
Uphof, J.C. Th. 1968. Dictionary of economic plants. 2nd ed. Verlag von J. Cramer.
Hartwell, J.L. 1967-71. Plants used against cancer. A survey. Lloydia 30-34.

Bazak (Sambucus ebulus)- tincture

БУЗИНА ТРАВЯНИСТАЯ НАСТОЙКА КОРНЯ 100МЛ

• Sambucus ebulus elburensis fruits: A good source for antioxidants

  Sambucus ebulus elburensis fruits: A good source for antioxidants

   Abstract

  The antioxidant activity of methanol and aqueous extract of Sambucus Ebulus (SE) was examined employing various in vitro assay systems, i.e. DPPH and nitric oxide radical scavenging, reducing power, linoleic acid and iron ion chelating power. IC50 for DPPH radical-scavenging activity was 202.50 ± 1.38 for aqueous extract (SW) and 723.62 ± 3.36 μg ml-1 for methanol extract (SM). Reducing powers of all the extracts also increased with the increase of their concentrations. Both of them exhibited a weak reducing power at 25-800 μg ml-1. The SW extract had shown better reducing power than SM. Tested extracts exhibited week Fe2+ chelating ability. Both extracts exhibited high antioxidant activity. There were no significant differences between them in peroxidation inhibition. SW extracts manifested better pattern of activity than Vitamin C and BHA at different incubation times. SE fruit extracts exhibited different levels of antioxidant activity in all the models studied. The SE extracts had good reductive capability for anti-lipid peroxidation and nitric oxide-scavenging activity. Aqueous extract had higher total phenol and flavonoid contents than methanol extract.

  Izvor: www.phcog.com

• SAMBUCUS EBULUS, INTRODUCTION TO MECHANISM OF ACTION; A CHEMICAL VIEWPOINT

  SAMBUCUS EBULUS, INTRODUCTION TO MECHANISM OF ACTION; A CHEMICAL VIEWPOINT

  Summary

  Essential oil composition of Sambucus ebulus leaf of (Caprifoliaceous) was analysed by GC and GC– MS. Sixty compounds were identified. The major components were β-bisabolene (11.4%), germacrene D (6.9%), geranyl acetate (5.6%) and α-cubebene (5.2%). The content of total phenolic compounds and flavonoids were also measured. Some detected compounds can be responsible for plant biological and/ or toxic activities.

  Key Words: Sambucus Ebulus; essential oil; β-Caryophyllene; α-Thujone.

  Introduction

  Four species of the genus Sambucus are growing in Iran. Of these species, S. ebulus (Caprifoliaceous) extensively grows in the northern regions of Iran (1,2).

  Iranian traditional medicine uses, in variousoccasions, the leaves and rhizomes of S. ebulus in treating some inflammatory cases such as, bee and nettle bites, arthritis, and sore-throat (3).

  In addition, it has been reported to be an insect repellent, anti-hemorrhoid, anti bacterial toward Helicobacter pylori, useful in the treatment of burns and infectious wounds, edema, eczema, urticaria, the cold, inflammation and rheumatism (2,4,5). Despite sporadic references on the activity of SE, there exist little or no systematic records on the use of SE as a widely accepted medicinal plant in Iran. Recently a significant anti-inflammatory activity was reported (1,2). Flavonoids, steroids, tannins, glycosides, cardiac glycosides, caffeic acid derivatives, ebulitins, volatile substances, phenol and flavenoid content of this species was previously reported (1,6). Recently we have reported good antioxidant activity of SE fruit and flowers (7,8). Studies have established extracts of some plants which are rich in flavonoids (9) and many of these phenolic compounds have shown to be cytoprotective by reducing oxidative stress (10,11), thereby giving a solid basis to the proposal that the antioxidant content of plants could account for its cardioprotective properties (12). Assuming its therapeutic benefit, it is attributed to antioxidant activity, we have reported antioxidant potential of fruit and flowers extracts of S. ebulus (7,8). For this purpose, and in continuation of our research, total phenol and flavonoids contents of S. ebulus leaf extract were measured. To the best of our knowledge, no information is available about the composition of the S. ebulus leaf essential oil from Iran. In this study, chemical composition of volatile oil also was evaluated. It seems some compounds in leaf composition can play a role in interpretation of mode of action in some biological and/or toxic activities that have been reported previously from S. ebulus.

  Izvor: pharmacologyonline.silae.it/

• SAMBUCUS EBULUS - FROM TRADITIONAL MEDICINE TO RECENT STUDIES

  SAMBUCUS EBULUS – FROM TRADITIONAL MEDICINE TO RECENT STUDIES

  ABSTRACT

  Sambucus ebulus L. (Dwarf elder) is an herbaceous plant well-known in traditional medicine of Bulgaria and other countries from Central Europe to the Middle East. It is used for treatment of inflammation-related gastrointestinal disorders, influenza, kidney and lung diseases, and rheumatoid arthritis as well as of wounds, snake and insect bites bites. Recent research of Dwarf elder shows a high content of total polyphenols, anthocyanin, quercetin and vitamin C, which may be related to its antioxidant activity. Compounds with antiinflammatory and antinociceptive action such as chlorogenic and ursolic acids in the herb have been established, too.

  Some studies reveal anticancer properties of the herb, and plant ebulins are considered as the main compounds with anticancer properties. Fruit extracts modulate the gene expression of antioxidant enzymes in a preadipocyte cell culture model. Data available indicate that Dwarf elder is a good source of phytotherapeutic means to treat pathological conditions related to inflammation and oxidative stress.

  Key words: Sambucus ebulus, traditional medicine, polyphenols, antioxidant effect, anti-inflammatory effect, antimicrobial effect

  INTRODUCTION

  Sambucus ebulus L. (SE) (Dwarf elder) is an herbaceous plant well-known in traditional medicine of Balkans and Anatolia for its healing effects in many disorders. It has been used for a long time for treatment of inflammation-related gastrointestinal disorders, influenza, kidney and lung diseases, and rheumatoid arthritis as well as of wounds, snake and insect bites. Traditional medicine provides more data about elderberry fruit usage as immune stimulator, for treatment of respiratory and gastrointestinal diseases, dropsy, and even as an anticancer agent (16,22,31,39). Recent research reveals the phytochemical composition and many biological activities of SE in different study models. This review aims at summarizing the traditional use of this plant as a remedy and phytotherapeutic source useful in inflammation-related disorders.

  …..

  CONCLUSION

  The high AOA, along with the proven antiinflammatory properties of SE imply the usage of the plant in various pathological conditions involving oxidative stress and inflammation. Studies revealing the possibilities for the application of SE derivatives in cancer therapy should continue, as scientific data indicate the plant’s potential to reduce effectively cancer cell lines viability via protein synthesis inhibition. In Bulgaria and in the other Balkan countries, there is a common use of traditional medicine along with a consumption of tea, syrups, and jams in everyday life. This suggests a need for further research in order to clarify the effects and mechanisms of SE influence on human health.

  Izvor: press.mu-varna.bg

• Wound healing potential of Sambucus ebulus L. leaves

  Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside.
  Abstract
  ETHNOPHARMACOLOGICAL RELEVANCE:
  The leaves of Sambucus ebulus L. are used in Turkish folk medicine for treatment of high fever, rheumatic pains, snake bites and wounds.
  CONCLUSION:
  The experimental data revealed that the methanolic extract of Sambucus ebulus leaves displayed remarkable wound healing activity.

  Conclusion According to experimental results, crude methanol extract of Sambucus ebulus L. was found to have better activity on the wound healing compared to the other extracts and the fractions. This might be due to the synergistic effect of the constituents present in the methanolic extract. Furthermore, this study provides scientific evidence to the ethnomedicinal utilization ofSambucus ebulusleaves in Turkish folk medicine.

  Izvor: www.researchgate.net

• EFFECTS OF A TOPICAL PREPARATION CONTAINING SAMBUCI FOLIUM

  EFFECTS OF A TOPICAL PREPARATION CONTAINING SAMBUCI FOLIUM EXTRACT IN EXPERIMENTAL MODEL OF THERMAL SKIN BURNS
  Abstract
  The astringent, anti-inflammatory, antiseptic and cicatrizing effect of a coldcream
  containing Sambuci folium soft extract was established in experimental model of thermal skin burns. In the first group, treated with cold-cream containing 10% vegetal extract, had a favourable evolution, the wound healing being almost complete after 21 days. The reference group, treated with 1% silver sulfadiazine cream, and the control group, treated with cold-cream base, showed a delay of wound healing, the epithelisation after 21 days being incomplete.

• Sambucus ebulus Medicinal uses (Warning!)

  Sambucus ebulus

  Dwarf Elder a perennial member of the Sambucus genus in the family Caprifoliaceae.

  Medicinal uses (Warning!)

  The leaves are antiphlogistic, cholagogue, diaphoretic, diuretic, expectorant and laxative. The fruit is also sometimes used, but it is less active than the leaves. The herb is commonly used in the treatment of liver and kidney complaints. When bruised and laid on boils and scalds, they have a healing effect. They can be made into a poultice for treating swellings and contusions. The leaves are harvested in the summer and can be dried for later use.

  The root is diaphoretic, mildly diuretic and a drastic purgative. Dried, then powdered and made into a tea, it is considered to be one of the best remedies for dropsy. It should only be used with expert supervision because it can cause nausea and vertigo.

  A homeopathic remedy is made from the fresh berries or the bark. It is used in the treatment of dropsy.

  Izvor: practicalplants.org

• Antioxidant, antimicrobial and anticarcinogenic activities of Sambucus ebulus L.

  Antioxidant, antimicrobial and anticarcinogenic activities of Sambucus ebulus L. flowers, fruits and leaves

  …

  The strongest anticarcinogenic activity was found in leaf extract. The value of 33.81% is a significant value for anticarcinogenic assays. In addition, assays can be tested in increasing concentration.

Burjan (Sambucus ebulus)

German Commission D Monographs (Phytotherapy) preparationes

Hahnemanns Apotheker-Lexikon