Miloduh – Hyssopus officinalis (Lamiaceae)

Hyssopus officinalis (Lamiaceae)

How used: Medicinal

Activities: 147 Chemicals w/Activities: 42 Chemicals: 56

Activity: Pesticide, Perfumery, Flavor, Insectifuge, Antibacterial, Irritant, Antiseptic, Herbicide, Antispasmodic, Fungicide, Antiacetylcholinesterase, Antiinflammatory, Expectorant, Sedative, Transdermal, Antioxidant, Allergenic, Spasmogenic, Allelopathic, Antifeedant, Spasmogenic, Aldose-Reductase-Inhibitor, Convulsant, Antimalarial, Antiulcer, Acaricide, Insecticide, Antiplasmodial, Allelochemic, Myorelaxant, Antiacne, Antiviral, ACE-Inhibitor, Antiflu, Neurotoxic, Antiasthmatic, Interleukin-6-Inhibitor, Cancer-Preventive, Trichomonicide, P450-2B1-Inhibitor, Analgesic, Antimutagenic, Apoptotic, Antitumor, Anticancer, Chemopreventive, Antinociceptive, Antitussive, Epileptigenic, Anticariogenic, Antiproliferant, Candidicide, Vulnerary, P450-Inducer, Antistaphylococcic, Antiallergic, Antinitrosaminic, Bacteriostatic, GST-Inducer, Antilithic?, …

Reference:

Aloe Research Council – Duke writeup of non-peer reviewd book by Coats and draft by Henry

Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.

Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp.

Jim Duke’s personal files.

Buchbauer et al, e.g.Buchbauer et al,1993.Therapeutic properties of essential oils and fragrances. Chap.12 in Teranishi,R, Buttery,R.G and Sugisawa,H. Eds. Bioactive Volatile Compounds from Plants. ACS Symposium Series 525. Amer. Chem. Soc., Washington DC

Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine – A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.

Blaschek, W., Hansel, R., Keller, K., Reichling, J., Rimpler, H., and Schneider, G. eds. 1998. Hager’s Handbuch der Pharmazeutischen Praxis, Auflage Band 2 (A-K), 909 pp., (L-Z), 858 pp. Springer-Verlag, Berlin.

Okamura, K., Iwakami, S., Matsunaga, T. 1992. Biological Activity of Monoterpenes from Trees. Toyama-Ken Yakuji Kenkyusho Nenpo, (20): 95-101.

Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents – A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.

Economic & Medicinal Plant Research, 5: 195.

Chin. J. Tuber. Respir. Dis., 4:203, 1982.

Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

Martindale’s 28th

Economic & Medicinal Plant Research, 6: 235.

Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY.

Rao, V.S.N., Menezes, A.M.S., Viana, G.S.B. 1990. Effect of myrcene on nociception in mice. J. Pharm. Pharmacol. 42: 877-878, 1990.

Muroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105.

Chin. J. Tuber. Respir. Dis.

Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

Hyssopus officinalis (Lamiaceae)

Hyssopus officinalis (Lamiaceae)
Ancient Greeks used Hyssopus officinalis (Lamiaceae) to treat coughing and wheezing, to bring relief for chest ailments, such as the common and other respiratory infections. The sweat-inducing properties may help to break a fever. People have tried Hyssop tinctures to relieve anxiety, soothe the nerves, treat insomnia and enhance mental clarity. Hyssopus officinalis (Lamiaceae) plant extracts have also been used to cleanse and detoxify the intestinal tract. The extract of Hyssopus officinalis (Lamiaceae) can help in the treatment of conjunctivitis and as a natural remedy that is massaged into the skin for poor circulation, itchy skin, fresh bruises, burns, muscle pain, old wounds, bug bites, as well as other skin problems. Lesser known uses for this herb are for the stimulation of the menstruation and relief of PMS. Known for its diuretic effects, Hyssopus officinalis (Lamiaceae) liquid extracts are used to boost the secretion and discharge of urine. It has also been used to open the pores of the body.
Modern practitioners of herbal medicine prescribe Hyssopus officinalis (Lamiaceae) for respiratory illness. It is believed to help reduce and get rid of phlegm, particularly with chronic congestion and unproductive coughs. It has been a time-honored remedy to ease asthma, bronchitis, coughs, chest colds and stuffy nose. Hyssopus officinalis (Lamiaceae) also soothes mucous membranes in the respiratory system and eases hoarseness (in laryngitis and pharyngitis), and sore throat. This has also been used as herbal support for the immune system to promote fever and help fight off colds and other viral infections. Its anti-inflammatory properties can also relieve deep tissue pain and muscle soreness.
Hyssopus officinalis (Lamiaceae) has been used to relieve intestinal gas and soothe the mucous lining of the bowel while clearing mucus from the intestines. Hyssop herbal extract is used orally to treat upset stomach, liver and gallbladder complaints, and indigestion. The property of Hyssopus officinalis (Lamiaceae) herbal supplement help to relieve stomachaches and flatulence. It is useful when treating colic and is a good ally to laxative herbs, helping to reduce cramping during bowel movements. Hyssop extract has strong vermifugal properties, which means it may be helpful for eliminating parasites and expelling intestinal worms.
Hyssopus officinalis (Lamiaceae) liquid herbal extract can be used to offer comfort and relief due to irregular periods. This essential herb has been found to be a great help for women who may suffer from cramps or have poor blood flow. Hyssopus officinalis (Lamiaceae) liquid tincture is easily absorbed by your body and can reach the bloodstream quickly to diminish pain. During periods of water retention, due to menstrual cycles, Hyssopus officinalis (Lamiaceae) herbal tincture helps with bloating and swelling. It is also known to treat fatigue, nausea, anxiety, and stress.
Used to promote good circulation, this herbal extract may be important to those with diabetes-related disorders, and those with hypotension. It has been used to flush out excess sodium and lower high blood pressure. At the same time, it may help to raise low blood pressure, and soothe the entire body.
Hyssopus officinalis (Lamiaceae) is a gently relaxing nerve tonic, suitable for nervous exhaustion when linked with overwork and anxiety or depression. It is thought to be helpful for easing feelings of grief and guilt and a tonic to strengthen the immune system and improve the body when in a weakened condition. The nervine properties in Hyssopus officinalis (Lamiaceae) treat and nourish the nervous system. Some herbalists recommend Hyssopus officinalis (Lamiaceae) herbal tincture to help balance the emotional swings that are so common during a mid-life transition. It has also been recommended for to treat hysteria and a form of epilepsy called petit mal. Hyssop can be an effective sedative when consumed before bedtime with Chamomile and Valerian Root. Due to this nervine property Hyssopus officinalis (Lamiaceae) should be avoided during pregnancy and by individuals who have a history of seizures.
Its anti-inflammatory properties are beneficial for reducing painful swelling in the joints, as found in cases rheumatism, arthritis, and gout. Hyssopus officinalis (Lamiaceae) contains anti-spasmodic compounds that help to constrict blood vessels. This can assist in easing the effects of muscular spasms and cramps.
Scientists are investigating Hyssopus officinalis (Lamiaceae) because it has been used since ancient times to both as a general pesticide and as a treatment for lice. And, Hyssop is great for relieving inflammation and the discomfort of insect bites. A few drops of Hyssopus officinalis (Lamiaceae) tincture added to cream or lotion helps to heal skin, reduce scarring and speeds healing of bruises, making them fade more quickly. As an antiviral, Hyssop combats herpes simplex virus and treats cold sores.

Another important health benefit of Hyssopus officinalis (Lamiaceae) includes its astringent properties. Hyssopus officinalis (Lamiaceae) herbal extract can be used to slow down the aging process, helping skin conditions such as sagging and loose skin, along with wrinkles and fine lines. Hyssop stops your limbs from contracting, which prevents your muscles and skin from shrinking to help prevent blood vessel hemorrhage. This action is also believed to help reduce the chances of loosening of the teeth.

Ingredients: Hyssopus officinalis (Lamiaceae), Structured Water, 96% Alcohol.

Non-Alcohol: Hyssopus officinalis (Lamiaceae), Structured Water, Vegetable Glycerin.

All of our ingredients are Certified Organic, Kosher, or Responsibly Wildcrafted. No genetically modified organisms (GMO’s) are involved. All other products that are distributed by us meet our high-quality standards.

Instructions: Use 10-20 drops in j the ice, water, under the tongue or as desired. May be taken 3 times daily. Shake well. Store in cool dark place. Keep out of reach of children.

Contraindications: Hyssopus officinalis (Lamiaceae) should not be taken for more than two weeks without advice of a physician. Excessive use (many times the recommended dosage) may cause seizures. Pregnant women, those who suffer from epilepsy or from high blood pressure should avoid Hyssopus officinalis (Lamiaceae).

Disclaimer: The information presented herein by Herbal Alchemy is intended for educational purposes only. These statements have not been evaluated by the FDA and are not intended to diagnose, cure, treat or prevent disease. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

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Hyssop
Medically reviewed on Jun 7, 2018

Overview Reviews More
What is Hyssop? Hyssop is a perennial plant which is native to the Mediterranean region and has been imported and naturalized in the US and Canada. It grows along roadsides and is sometimes found as a garden herb. Hyssop is quite similar in appearance to other members of the mint family. Its volatile oil possesses a highly aromatic camphor-like smell.

Scientific Name: Hyssopus officinalis

Common Names: It should be noted that there are a number of other common plants found in North America that go by a variation of the name „hyssop.“ These include giant hyssop (Agastache sp.), hedge hyssop (Gratiola officinalis), and water hyssop (Bacopa sp.). None of these plants are members of the genus Hyssopus.

What is it used for?: Traditional/Ethnobotanical uses Hyssop has been noted for centuries in herbal medicine. In addition, there are a number of references in the Bible to plants called „hyssop,“ although there is considerable controversy regarding the actual identity of these plants. There is little evidence that the plant mentioned in Bible was actually „H. officinalis.“

The ancient use of this plant was an insecticide, insect repellent, and pediculicide (lice eradicator). Extracts of plant have been used as a fragrance in soaps and perfumes, and to flavor liqueurs, sauces, puddings, and candies.

Miscellaneous uses: The plant has been used in herbal medicine for the treatment of sore throats, colds, hoarseness, and as an expectorant. Some herbalists also believe that hyssop has beneficial effects for asthma, urinary tract inflammation, and appetite stimulation. Its effectiveness in relieving gas and colic also are listed under its medicinal uses. None of these uses have been studied clinically.

Although an extract of the leaves has been suggested for the treatment of wounds, there does not appear to be strong evidence for its effectiveness as an antibacterial.

Still used today by herbalists for its beneficial effects, hyssop’s volatile oil represents the most important fraction of this plant. It may have some small beneficial effect in the treatment of sore throats and as an expectorant. However, clinical studies are lacking for any medicinal use of hyssop.

What is the recommended dosage?: There is no clinical evidence for hyssop upon which dosing recommendations can be based.

Contraindications: Contraindications have not yet been identified.

Pregnancy/Lactation: Avoid use. Documented adverse effects. Hyssop has emmenagogue (to stimulate menstrual flow) and abortive effects.

Interactions: None well documented.

Side Effects: No data.

Toxicology: Hyssop is classified among plants „generally recognized as safe (GRAS)“ by the FDA; however, 3 recent studies demonstrate convulsant actions associated with the plant’s use in rats.

References: 1. Hyssop. Review of Natural Products. factsandcomparisons4.0 [online]. 2005. Available from Wolters Kluwer Health, Inc. Accessed April 17, 2007.
Further information: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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Hyssop
OverviewReviewsMore
Scientific Name(s): Hyssopus officinalis L.
Common Name(s): Ezov, Hyssop, Hyssopus

Clinical Overview
Use Toxic effects of hyssop essential oil limit therapeutic applications. Although no clinical evidence supports use, animal research indicates the potential for use of hyssop extract in diabetes and for its antimicrobial and CNS effects.

Dosing No clinical evidence is available to determine hyssop dosing recommendations.

Contraindications Contraindications have not been identified.

Pregnancy/Lactation Avoid use. Documented adverse effects.

Interactions None well documented.

Adverse Reactions Information is limited; however, case reports of seizures exist.

Toxicology Convulsant toxic effects of the essential oil have been established in rodents.

Botany Hyssop is a perennial plant native to the Mediterranean that has been imported to and naturalized in the United States and Canada. It grows along roadsides and is sometimes found as a garden herb, growing to about 0.6 m in height. Its thin pointed leaves extend onto a central herbaceous stem that is sessile in form. The small blue tubular flowers grow from the upper leaf axils and bloom from July to October. The fruit contains 4 nutlets, each having one seed, and the plant has an aromatic camphor-like scent.1, 2, 3

A number of other common plants found in North America go by a variation of the name „hyssop.“ These include giant hyssop (Agastache spp.), hedge hyssop (Gratiola officinalis L.), and water hyssop (Bacopa spp.); none of these plants are members of the genus Hyssopus, nor are they all members of the family Laminaceae.1

History In ancient times, the hyssop plant was used as an insecticide, insect repellent, and pediculicide,3 and also in religious rituals; however, there is little evidence that mentions of „hyssop“ in the Bible actually refer to H. officinalis.4, 5 The plant has been used in herbal medicine for the treatment of sore throats, colds, hoarseness, and as an expectorant.2, 3 Some herbalists also believe that hyssop has beneficial effects in asthma, urinary tract inflammation, lack of appetite, gas, and colic. Extracts of the plant have been used in perfumes and soaps, and to flavor liqueurs, sauces, puddings, and candies.2, 3

Chemistry
As a member of the mint family, hyssop contains a number of fragrant, volatile components. The plant contains up to 2% of a volatile oil,2 primarily composed of pinocamphone, isopinocamphone, alpha- and beta-pinene, camphene, and alpha-terpinene.6

Other constituents of the plant include glycosides (hyssopin as well as the flavonoid glycosides, hesperidin, and diosmine), tannin 5% to 8%, oleanolic acid, ursolic acid, beta-sitosterol, marrubiin, and resins. Crude hyssop also contains rosmarinic acid 0.5% and total hydroxycinnamic derivatives 2.2%.2, 6 Flavonoids with antioxidant activity have been identified.7

Uses and Pharmacology
Antimicrobial Animal data Antibacterial and antiviral activity has been described for leaf extracts and the essential oil of hyssop. In vitro studies showed antibacterial activity against several human pathogens6; however, the preservative effect of hyssop added to ground beef was limited.8

In vitro antiviral activity has been investigated against herpes simplex viruses 1 and 29, 10 and HIV,11 with some studies suggesting the effect is limited to the viral envelope10 and hence ineffective against nonenveloped viruses such as human norovirus.12

Clinical data Research reveals no clinical data regarding the use of hyssop oil for antimicrobial effects.

Asthma Animal data Asthmatic mice treated with hyssop extract (0.04 g per 10 g) had decreased airway remodeling and fewer symptoms of cough, shortness of breath, anxiety, and cyanosis.13 A decrease in symptoms and changes in various disease marker proteins were similar to the group treated with dexamethasone. The same research group used the same treatments to examine immune effects and noted that hyssop-treated asthmatic mice had significant reductions in mucus secretion and reductions in immunoglobulin E (IgE) and IgG similar to the improvements seen in the dexamethasone group.14

Clinical data Research reveals no clinical data regarding the use of hyssop oil for antiasthmatic effects.

CNS Animal data Inhalation of hyssop essential oil was sedative in agitated (caffeine-stimulated) mice.15 Commercial preparations of hyssop essential oils produced convulsions in rats at 0.13 g/kg and death at 1.25 g/kg.16

Clinical data Research reveals no clinical data regarding the use of hyssop for CNS effects, and case reports of seizures due to consumption of hyssop essential oil exist (see Toxicology).

Diabetes Animal data Limited experiments suggest an extract of the dried leaves of hyssop contains glucopyranosides that appear to have alpha-glucosidase inhibitory activity capable of reducing postprandial hyperglycemia.17, 18

Clinical data Research reveals no clinical data regarding the use of hyssop for diabetes.

Dosing No clinical evidence is available to determine hyssop dosing recommendations.

Pregnancy / Lactation Avoid use. Hyssop has emmenagogue and abortifacient effects.19, 20

Interactions Reports are lacking.

Adverse Reactions Hyssop oil was nonirritating to the skin in animal and human studies.2 Older case reports of seizures related to consumption of hyssop and sage oils exist.14, 21

Research reveals little or no information regarding adverse reactions with hyssop use.

Toxicology In rats, commercial preparations of hyssop essential oils produced convulsions at 0.13 g/kg and death at 1.25 g/kg, and case reports of seizures in adults and children exist.16, 21 The neurotoxicity of hyssop appears to be related to 2 terpene ketones, pinocamphone and isopinocamphone; although, other monoterpenes with similar chemical structures, such as camphor, thujone, and cineole, are known to have epileptogenic properties.14, 21

A study using hyssop in combination with other herbs in the feed of horses showed no differences in hematologic or biochemical parameters compared with placebo feed.22

References
1. Hyssopus officinalis L. USDA, NRCS. The PLANTS Database (http://plants.usda.gov/java/, 2016). National Plant Data Center, Baton Rouge, LA 70874-4490 USA.
2. Khan IA, Abourashed EA. Leung’s Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. 3rd ed. Hoboken, NJ: Wiley; 2009.
3. Duke J, Bogenschutz-Godwin M, duCellier J, Duke P. Handbook of Medicinal Herbs. 2nd ed. Boca Raton, FL: CRC Press; 2002.
4. Harrison R. The Biblical problem of hyssop. The Evangelical Quarterly. 1954;26(4):218-224.
5. Luca LM, Norum KR. Scurvy and cloudberries: a chapter in the history of nutritional sciences. J Nutr. 2011;141(12):2101-2105.22013203
6. De Martino L, De Feo V, Nazzaro F. Chemical composition and in vitro antimicrobial and mutagenic activities of seven Lamiaceae essential oils. Molecules. 2009;14(10):4213-4230.19924059
7. Fathiazad F, Mazandarani M, Hamedeyazdan S. Phytochemical analysis and antioxidant activity of Hyssopus officinalis L. from Iran. Adv Pharm Bull. 2011;1(2):63-67.24312758
8. Michalczyk M, Macura R, Tesarowicz I, Banaś J. Effect of adding essential oils of coriander (Coriandrum sativum L.) and hyssop (Hyssopus officinalis L.) on the shelf life of ground beef. Meat Sci. 2012;90(3):842-850.22153611
9. Schnitzler P, Koch C, Reichling J. Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood. Antimicrob Agents Chemother. 2007;51(5):1859-1862.17353250
10. Koch C, Reichling J, Schneele J, Schnitzler P. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine. 2008;15(1-2):71-78.17976968
11. Kreis W, Kaplan MH, Freeman J, Sun DK, Sarin PS. Inhibition of HIV replication by Hyssop officinalis extracts. Antiviral Res. 1990;14(6):323-337.1708226
12. Kovač K, Diez-Valcarce M, Raspor P, Hernández M, Rodríguez-Lázaro D. Natural plant essential oils do not inactivate non-enveloped enteric viruses. Food Environ Virol. 2012;4(4):209-212.23412892
13. Ma X, Ma X, Ma Z, et al. The effects of Uygur herb Hyssopus officinalis L. on the process of airway remodeling in asthmatic mice. Evid Based Complement Alternat Med. 2014;2014:710870.25383084
14. Ma X, Ma X, Ma Z, et al. Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation on a chronic asthmatic mouse model. Exp Therapeu Med. 2014;8(5):1371-1374.25289025
15. Lim WC, Seo JM, Lee CI, Pyo HB, Lee BC. Stimulative and sedative effects of essential oils upon inhalation in mice. Arch Pharm Res. 2005;28(7):770-774.16114490
16. Millet Y, Jouglard J, Steinmetz MD, Tognetti P, Joanny P, Arditti J. Toxicity of some essential plant oils. Clinical and experimental study. Clin Toxicol. 1981;18(12):1485-1498.7333081
17. Matsuura H, Miyazaki H, Asakawa C, Amano M, Yoshihara T, Mizutani J. Isolation of alpha-glusosidase inhibitors from hyssop (Hyssopus officinalis). Phytochemistry. 2004;65(1):91-97.14697274
18. Miyazaki H, Matsuura H, Yanagiya C, Mizutani J, Tsuji M, Ishihara C. Inhibitory effects of hyssop (Hyssopus officinalis) extracts on intestinal alpha-glucosidase activity and postprandial hyperglycemia. J Nutr Sci Vitaminol (Tokyo). 2003;49(5):346-349.14703310
19. Ernst E. Herbal medicinal products during pregnancy: are they safe? BJOG. 2002;109(3):227-235.11950176
20. Quattrocchi U. CRC World Dictionary of Medicinal and Poisonous Plants. Boca Raton: CRC Press; 2012. 13:978-1-4822-5064-0.
21. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol. 1999;246(8):667-670.10460442
22. Pearson W, Charch A, Brewer D, Clarke AF. Pilot study investigating the ability of an herbal composite to alleviate clinical signs of respiratory dysfunction in horses with recurrent airway obstruction. Can J Vet Res. 2007;71(2):145-151.17479778
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This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.

This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.

Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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Preparati

Miloduh – Hyssopus officinalis (Lamiaceae)