Kostrika (Ruscus aculeatus-Liliaceae)

Kostrika (Ruscus aculeatus-Liliaceae)

BILJNI PREPARATI KOSTRIKE: Ruscus aculeatus L.

TINKTURA I MATIČNA TINKTURA

Preparati KOSTRIKE su namenjeni kod problema sa kožom, cirkulacijom, izuzetan venski tonik, u savremenoj fitoterapiji se upotrebljava kao pomoćno sredstvo za lečenje hemoroida, jača tonus krvnih sudova anorektalnog regiona i ublažava tegobe. jača tonus krvnih sudova anorektalnog regiona i ublažava tegobe (svrab, osećaj pečenja, vlaženje, bolovi u predelu čmara…) koje nastaju zbog akutne i hronične venske insuficijencije, kod poremećaja venske i limfne cirkulacije donjih ekstremiteta (bolovi, umor, osećaj težine u nogama, grčevi, otoci, utrnutost, spazam,…).

PREPARATI KOSTRIKE, Ruscus aculeatus (Liliaceae)

TINKTURA, KOSTRIKA HSS SUŠENI RIZOM, DER 1:10,

MATIČNA TINKTURA, KOSTRIKA TM SVEŽI RIZOM, DER 1:2.

Rusci aculeati rhizomae recentis extractum ethanolicum liquidum

DEFINITION:
Butcher’s broom mother tincture complies with the requirements of the general technique for the preparation of mother tinctures (see Homoeopathic Preparations (1038) and French Pharmacopoeia Authority Supplement). The mother tincture is prepared with ethanol (65 per cent V/V) using the fresh, whole or fragmented underground part of Ruscus aculeatus L.
Content: minimum 0.25 per cent of total saponins, expressed as ruscogenins. [mixture of neoruscogenin (MF: C27H40O4; MW: 428,604100 g/mol−1) and ruscogenin (MF: C27H42O4; MW: 430,619980 g/mol−1)].

PREPARATI KOSTRIKE, Ruscus aculeatus (Liliaceae)

TINKTURA I MATIČNA TINKTURA, hidroetanolni tečni ekstrakt svežeg korena

KOSTRIKA  KOSTRIKA HSS i TM: 

Rusci aculeati rhizomae recentis extractum ethanolicum liquidum

 

ATC:

 – antiinflamatik, – antitrombotik, – vazokonstriktor.

 

U skladu sa:

1) Based on Article 10a of Directive 2001/83/EC as amended (well-established use), Based on Article 16d(1), Article 16f and Article 16h of Directive 2001/83/EC as amended (traditional use), DIRECTIVE 2004/24/ECOF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 31 March 2004.

2) Eu. Ph. 8, 01.07.2015.  monografijom: 1847 Rusci rhizoma

3) European Medicines Agency Doc. Ref. EMEA/HMPC/261938/2007., London, 4 September 2008.: Community herbal Monograph on Ruscus aculeatus L., rhizoma

4) European Medicines Agency Doc. Ref. EMEA/HMPC/261939/2007., London, 4 September 2008.: Assessment report on Ruscus aculeatus L., rhizoma

5) Fr. Ph. 2007 ANSM: Ruscus aculeatus ad praeparationes homoeopathicas (PETIT HOUX POUR PRÉPARATIONS HOMÉOPATHIQUES)

 

Biljni preparati u tečnom obliku (nerazblaženi ili razblaženi) za oralnu i lokalnu upotrebu.

 

a) Ruscus aculeatus L., rhizoma (Butcher’s broom fresh, whole or fragmented underground part ) Fr. Ph.,

b) Ruscus aculeatus L., rhizoma (Butcher’s broom dried, whole or fragmented underground part ) HAB method 4a,

c) Ruscus aculeatus L., planta tota (Butcher’s broom fresh flowering plant).

 

Sastav:

a) tečni ekstrat (DER 1:2), ekstrakcioni rastvarač etanol 65% (v/v),

b) tečni ekstrat (DER 1:10), ekstrakcioni rastvarač etanol 90% (v/v).

 

Ruscus aculeatus L., sadrži 93 hemijskih jedinjenja koja ispoljavaju 407 istraženih dejstava (*podaci ažurirani januara 2019.).

 

Sadržaj:

a) minimalno 0,25% m/m ukupnih saponina, izraženih kao ruskogenini (ruscogenins)/ miksture neoruskogenina i ruskogenina [mixture of neoruscogenin (MF: C27H40O4; MW: 428,604100 g/mol−1) and ruscogenin (MF: C27H42O4; MW: 430,619980 g/mol−1)].

b) u većoj koncentraciji sadrži glikolnu kiselinu, saponine, rutin, hrizofaninsku kiselinu, ruscin, ruskonin, ruskodibenzofuran, …

c) više od svih biljaka sadrži ruskogenina i ruskozida,

d) vode sadrži do 69,8 % (koren – rizom).

 

Indikacije:

Biljni preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva.

Upotreba kod cirkulatornih tegoba (hronične venske insuficijencije CVI), limfaedema, ortostatske hipotenzije, konstipacije, hemoroida, zastoja tečnosti u organizmu, preloma kostiju, …

 

Dr. Džems Djuk (Dr. James Duke) u Handbook of Medicinal Herbs, 2nd Ed. (2002). CRC Press, navodi sledeće:

 – ima jako dejstvo kod: hronične venske insuficijencije (CVI), hemoroida, inflamacija, retinoza, zastoja tečnosti.

– delotvoran kod: peska i kamena u žuči, kapilarne slabosti, inflamacija (kod artroza i reumatizma), hipertrigliceridemije, svraba, grčeva, bolova, flebitisa, edema, tromboza, varikoza, …

 – u narodnoj medicini kod: kod groznice, peska žučne kese, Tu.(prostate), žutice, konstriktor limfnih perifernih sudova, fraktura, žutice, nefroza, prostatitisa, anoreksije, ateroskleroza, reumatizma, skrofula, Ulcus cruris-a, uteritisa, konstipacije, hidropsije, disurije, groznice, smrzotina, dispneje, katara, respiratornih problema, …

 – spoljašnja primena kod: proširenih vena, celulita, fraktura, …

– upotrebljava se kao: antiinflamatik, diuretik, vazokonstriktor, venotonik, alfa adrenergik, tonik, vazokonstriktor, aperient, antipiretik, biter, apertiv, deobstruent, djiaforetik, emenagog, ekspektorant, antiagregant, laksativ, sudorifik, kapilarni protektor, …

Monografija nemačke E komisije (Commission E Monographs), terapijski vodič za biljne lekove, preporučuje Ruscus aculeatus za hemoroide, hroničnu vensku insuficijenciju i varikozne vene.

 

Doziranje i način primene:

do 2 mL (80 kapi) podeljeno u 2 do 4 doze.
Biljni preparat KOSTRIKA HSS i TM:
pojedinačna doza: 0,5-1 mL, preporučena dnevna doza (PDD): 2 mL.
Oralna (15 minuta pre obroka) i lokalna primena.
Upotreba na koži: aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja.

 

Napraviti pauzu posle 4 nedelje neprekidne upotrebe. Optimalna upotreba 8 do 12 nedelja.

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze.

 

Kontraindikacije:

preosetljivost na aktivne supstance,
preosetljivost na biljke porodice (genus Ruscus, family Asparagaceae).

Potrebna je pažljiva upotreba sa alfa adrenergičkim antagonistima (upotreba preparata može stimulisati CNS, povečati krvni pritisak, ubrzati srčani rad,…).

Čuvanje: na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju,  u dobro zatvorenoj originalnoj ambalaži.

Rok upotrebe: 5 godina, posle prvog otvaranja 6 meseci.

Pakovanje: 50 mL i 100 mL, standarne farmaceutske braon bočice; 250 mL, 500 mL, 1L i 5 L na zahtev.

Nutritivne informacije:

KOSTRIKA HSS i TM:

a) energetska vrednost u 100 mL: 1504 kJ/ 360 kcal,
u preporučenoj dnevnoj dozi (PDD) 2 mL: 30kJ/ 7,17 kcal,
suve materije (DR) više od 2,0% (Fr. Ph.).
b) energetska vrednost u 100 mL: 2218 kJ/ 530 kcal,
u preporučenoj dnevnoj dozi (PDD) 2 mL: 44,36 kJ/ 10,6 kcal,
suve materije (DR) više od 2,0% (Fr. Ph.).

Bez konzervanasa, proteina, masti i ugljenih hidrata.

KOSTRIKA HSS i TM su rukom rađeni proizvodi. 

CENOVNIK

TINKTURA, KOSTRIKA HSS, hidroetanolni tečni ekstrakt sušenog rizoma, DER 1:10 (HAB), isključivo na zahtev;

50 mL – 500,00 RSD (5 evra); 100 mL – 1000,00 RSD (10 evra);

MATIČNA TINKTURA, KOSTRIKA TM,  hidroetanolni tečni ekstrakt svežeg rizoma, DER 1:2,

50 mL – 600,00 RSD (5 evra); 100 mL – 1200,00 RSD (10 evra);

Podaci ažurirani januara 2019. godine.

Pogledati i ostale informacije na: http://www.biljni-preparati.com/preparati/kostrika-ruscus-aculeatus-liliaceae/

Ruscus aculeatus (Liliaceae)

Common names: Box-Holly; Butcher’s Broom

How used: Medicinal Activities: 407  Chemicals w/Activities: 52  All Chemicals: 93

Activity: Cancer-preventive, antioxidant, pesticide, hypocholesterolemic, hypotensive, antiinflammatory, cardioprotective, antidiabetic, antiosteoporotic, diuretic, antiarthritic, vasodilator, immunomodulator, anticataract, antiatherosclerotic, antispasmodic, antisyndrome-X, antihypertensive, antidepressant, antiacne, antiacne, antidepressant, antimutagenic, antilyme, antibacterial, antiradicular, immunostimulant, hypoglycemic, antidementia, antiobesity, anxiolytic, antirheumatic, antitumor, antifatigue, antiviral, antihepatotoxic, antiaggregant, antiepileptic, antiarrhythmic, Aldose-Reductase-inhibitor, antiPMS, analgesic, antimenopausal, antialzheimeran, anticlimacteric, ACE-inhibitor, antihangover, antialcoholic, antistress, antiasthmatic, antiviral, antihepatotoxic, antiaggregant, aldose-reductase-inhibitor, antiepileptic, antiarrhythmic, anticervicaldysplasic, antidote (Lead), Insulinogenic, Calcium-Antagonist, … ukupno 407 dejstava.

Reference:

Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.

Lawrence Review of Natural Products, 1995

Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X – The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95

Pedersen, M. 1987. Nutritional Herbology. Pederson Publishing. Bountiful, Utah. 377 pp.

Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp.

Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.

Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp.

Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

Abid Ali Khan, M.M., Jain, D.C., Bhakuni, R.S., Zaim, M., and Thakur, R.S. 1991. Occurrence of some antiviral sterols in Artemisia annua. Plant Science, 75: 161-165, 1991.

Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp.

Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.

Data by Dr. Dzejms A. Djuk (Dr. James A. Duke)

Butcher’s Broom

Scientific Name(s): Ruscus aculeatus
Common Name(s): Box holly, Butcher’s broom, Jew’s myrtle, Knee holly, Kneeholm, Pettigree, Sweet broom

Clinical Overview

Use

Butcher’s broom has been used traditionally as a laxative, mild diuretic, treatment for circulatory disease, chronic venous insufficiency, atherosclerosis, hemorrhoids, varicose veins, and as a cytotoxic agent. Positive findings for vascular insufficiency and related conditions are reported; however, quality clinical trials are generally lacking.

Dosing

Butchers broom has been used in clinical trials for chronic venous insufficiency standardized to 7 to 11 mg of ruscogenin. Extracts have been dosed at 16 mg daily for chronic phlebopathy, while a topical cream formulation was used to apply 64 to 96 mg of extract daily.

Contraindications

Contraindications have not yet been identified.

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking. Avoid use.

Interactions

None well documented. Theoretical interactions with alpha-adrenergic stimulating medicines may exist.

Adverse Reactions

Allergic contact dermatitis has been reported with topical formulations, whereas oral administration has been associated with GI side effects.

Toxicology

The extract from roots has been shown to be more toxic than from rhizomes and, in animal studies, led to convulsions, paralysis, GI inflammation, and dysentery. Severe visceral congestion eventually led to fatal respiratory failure.

Botany

Butcher’s broom is a low-growing common evergreen shrub. It is widely distributed, from Iran to the Mediterranean1 and the southern United States.2 The plant develops edible shoots from rhizomes that are similar to asparagus in form.3 Butcher’s broom has tough, erect, striated stems with false thorny leaves called cladophylles.4 The Asparagaceae family is formerly known as Liliaceae (lily). The nomenclature of this plant should not be confused with broom (Cytisus scoparius L.) or Spanish broom (Spartium junceum L.).

History

R. aculeatus was given its common name, butcher’s broom, because its stiff twigs were bound together and used by butchers in Europe to keep their cutting boards clean. The plant has a long history of use; more than 2000 years ago, it was noted as a laxative, diuretic, and a phlebotherapeutic agent.5 Extracts, decoctions, and poultices have been used throughout the ages, but the medicinal use of this plant did not become common until the last century. Early investigations during the 1950s indicated that extracts of the rhizomes of butcher’s broom could induce vasoconstriction and therefore might have use in the treatment of circulatory diseases. The increasing popularity of natural and herbal remedies in Europe in the 1970s reaffirmed its position in modern medicine. Novel uses for this plant have included its use as an anti-inflammatory agent and to prevent atherosclerosis. Butcher’s broom is the active component in several drug formulations and topical treatments for venous disease. Structural elucidation of active compounds and the discovery of new pharmacological activity, particularly as a cytotoxic agent, demonstrate the need for continued research on butcher’s broom.

Chemistry

A variety of compounds have been isolated from butcher’s broom. The 2 primary saponin compounds are ruscogenin and neoruscogenin.6 The ruscogenin content in underground and aboveground parts is approximately 0.12% and 0.08%, respectively.7 The plant also contains numerous furanostanol and spirostanol saponins.89 Two bisdesmosidic spirostanol saponins, aculeoside A and aculeoside B, also have been isolated.9 In addition, a variety of flavonoids, a fatty acid mixture composed primarily of tetracosanoic acid and related compounds, chrysophanic acid, sitosterol, campesterol and stigmasterol, have been isolated from the roots.3 Butcher’s broom also contains triterpenes, coumarins, sparteine, tyramine, and glycolic acid.10 The benzofuran euparone7 and the phenolic ruscodibenzofuran11 have been isolated. Plant extracts have revealed the presence of sulfated steroid saponins12 and the steroid glycosides, rusin and ruscoside.4

Constituents of butcher’s broom display alpha-adrenergic stimulating properties. The vasoconstrictive actions of ruscogenin and neoruscogenin have been attributed to the release of norepinephrine stored in the adrenergic nerve endings.13

Uses and Pharmacology

Cardiovascular effects

Animal data

A group of researchers reported on animal studies conducted in the 1990s, suggesting that compounds in Ruscus activated alpha-1 and alpha-2 receptors in smooth muscle, with resultant vasoconstrictive effects.514151617 Ruscogenins present in the extracts are ineffective on hyaluronidase activity but show exceptional anti-elastase activity.18

Clinical data

Quality clinical studies evaluating the effectiveness in venous insufficiency are limited. Studies evaluating multi-ingredient preparations (commonly Ruscus extract, hesperidin, and ascorbic acid) report positive findings.21920212223 A case report notes the potential use for butcher’s broom extract in orthostatic hypotension.5

Formulations of Ruscus extract are being investigated for the treatment of hemorrhoids, and the use of butcher’s broom for haemorrhoids is approved by the German Commission E.24 An older study reported positive findings for the use of butcher’s broom extract in microvascular-associated retinopathy.25

Other uses

Researchers have found that when a Ruscus extract is applied topically, a dose-dependent inhibition of the macromolecular permeability-increasing effect of histamine occurs.26Ruscus extract given IV (5 mg/kg) inhibits the macromolecular permeability-increasing effect of bradykinin, leukotriene B4, and histamine.26

In vitro studies indicate that compounds found in butcher’s broom may possess cytotoxic activity.82728

The combined action of flavonoids, sterols, and proteolytic enzymes found in the root has been shown to reduce dextran and carrageenan-induced rat paw edema, indicating that the extract may have anti-inflammatory activity.29

Dosing

Butchers broom has been used in clinical trials for chronic venous insufficiency standardized to 7 to 11 mg of ruscogenin.30 Hesperidin methyl chalcone has also been used as a marker for standardization in certain commercial multi-ingredient preparations. Extracts have been dosed at 16 mg daily for chronic phlebopathy, while a topical cream formulation was used to apply 64 to 96 mg of extract daily.203132

A 100 mg extract is reported to contain 0.5 mg of active ruscogenins.17

Pregnancy / Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking. Avoid use.

Preparations have been studied in pregnancy-related variscosities; however, safety has not been established.24

Interactions

None well documented. However, Ruscus extract exhibits alpha-adrenergic stimulating activity.13

Adverse Reactions

The German Commission E approves oral use of the rhizome for supportive therapy for the discomfort of chronic venous insufficiency and complaints of hemorrhoids and reports no known interactions.30 In a clinical trial, no adverse events were attributable to therapy by the 40 patients evaluated19; however, reports of edema, nausea, and abdominal pain from multi-ingredient preparations exist.

Allergic contact dermatitis has been reported with topical formulations, whereas oral administration has been associated with GI side effects (ie, chronic diarrhea, lymphocytic colitis, and cytolytic hepatitis).13

Toxicology

Oral ingestion of Butcher’s broom was suspected to have led to precipitation of diabetic ketoacidosis in a 39-year-old woman with poorly controlled diabetes previously in good health. She was admitted 5 days after she started Butcher’s broom for mild ankle swelling; 48 hours prior to admission she experienced vomiting and diarrhea before becoming acutely unwell. Improvement was noted within 12 hours of supportive treatment with IV fluids, an insulin drip, and calcium gluconate; she recovered fully.13

In animal studies, adverse events appear to be associated with the route of administration and the use of roots versus rhizomes. The extract from roots was found to be more toxic than from rhizomes and led to convulsions, paralysis, GI inflammation, and dysentery. Severe visceral congestion led to fatal respiratory failure.13

References

1. Tyler VE. The New Honest Herbal. Philadelphia, PA: G.F. Stickley Co.; 1987.

2. ElSohly M, Knapp JE, Slatkin KF, Schiff PL Jr, Doorenbos NJ, Quimby MW. Constituents of Ruscus aculeatusLloydia. 1975;38:106-108.237169

3. Mabberly DJ. The Plant-book. New York, NY: Cambridge University Press; 1987.

4. Di Lazzaro A, Morana A, Schiraldi C, Martino A, Ponzone C, De Rosa M. An enzymatic process for the production of the pharmacologically active glycosides desglucodesrhamnoruscin from Ruscus aculeatus L. J Mol Catal, B Enzym. 2001;11:307-314.

5. Redman DA. Ruscus aculeatus (butcher’s broom) as a potential treatment for orthostatic hypotension, with a case report. J Altern Complement Med. 2000;6:539-549.11152059

6. Pourrat H, Lamaison JL, Gramain JC, Remuson R. Isolation and confirmation of the structure by 13C-NMR of the main prosapogenin from Ruscus aculeatus L [in French]. Ann Pharm Fr. 1983;40:451-458.6847078

7. ElSohly MA, Doorenbos NJ, Quimby MW, Knapp JE, Slatkin DJ, Schiff PL Jr. Euparone, a new benzofuran from Ruscus aculeatusL. J Pharm Sci. 1974;63:1623-1624.4436800

8. Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida Y. Steroidal saponins from the underground parts of Ruscus aculeatusand their cytostatic activity on HL-60 cells. Phytochemistry. 1998;48:485-493.9654776

9. Mimaki Y, Kuroda M, Yokosuka A, Sashida Y. A spirostanol saponin from the underground parts of Ruscus aculeatusPhytochemistry. 1999;51:689-692.10392471

10. Ruscus aculeatus (butcher’s broom). Altern Med Rev. 2001;6:608-612.

11. ElSohly MA, Slatkin DJ, Knapp JF, Doorenbos NJ, Quimby MW, Schiff PI Jr. Ruscodibenzofuran, a new dibenzofuran from Ruscus aculeatus L. (Liliaceae). Tetrahedron. 1977;33:1711-1715.

12. Oulad-Ali A, Guillaume D, Belle R, David B, Anton R. Sulphated steroidal derivatives from Ruscus aculeatusPhytochemistry. 1996;42:895-897.

13. Sadarmin PP, Timperley J. An unusual case of butcher’s broom precipitating diabetic ketoacidosis. J Emerg Med. 2013;45(3):e63-e65.23849361

14. Marcelon G, Verbeuren TJ, Lauressergues H, Vanhoutte PM. Effect of Ruscus aculeatus on isolated canine cutaneous veins. Gen Pharmacol. 1983;14:103-106.6298054

15. Rubanyi G, Marcelon G, Vanhoutte PM. Effect of temperature on the responsiveness of cutaneous veins to the extract of Ruscus aculeatusGen Pharmacol. 1984;15:431-434.6150876

16. Bouskela E, Cyrino FZ, Marcelon G. Effect of Ruscus extract on the internal diameter of arterioles and venules of the hamster cheek pouch microcirculation. J Cardiovasc Pharmacol. 1993;22:221-224.7692161

17. Bouskela E, Cyrino FZ, Marcelon G. Inhibitory effect of Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch. J Cardiovasc Pharmacol. 1993;22:225-230.7692162

18. Facino RM, Carini M, Stefani R, Aldini G, Salbene L. Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedra helixAesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency. Arch Pharm. 1995;328:720-724.8554461

19. Cappelli R, Nicora M, Di Perri T. Use of extract of Ruscus aculeatus in venous disease in the lower limbs. Drugs Exp Clin Res. 1988;14:277-283.3048951

20. Berg D. Venous constriction by local administration of Ruscus extract [in German]. Fortschr Med. 1990;108:473-476.2227746

21. Aguilar Peralta GR, Arévalo Gardoqui J, Llamas Macías FJ, et al. Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. Int Angiol. 2007;26(4):378-84.18091707

22. Allaert FA, Hugue C, Cazaubon M, et al. Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort). Int Angiol. 2011;30(3):272-277.21617611

23. Reuter J, Wölfle U, Korting HC, Schempp C. Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications. J Dtsch Dermatol Ges. 2010;8(11):866-873.20707877

24. Abascal K, Yarnell E. Botanical Treatments for Hemorrhoids. Altern Complement Ther. 2005;11(6):285-289.15865494

25. Archimowicz-Cyrylowska B, Adamek B, Drozdzik M, et al. Clinical effect of buckwheat herb, Ruscus extract and troxerutin on retinopathy and lipids in diabetic patients. Phytotherapy Res. 1996;10:659-662.

26. Peneva B, Krasteva I, Nikolov S, Minkov E. Formulation and in vitro release of suppositories containing dry extract of Ruscus aculeatus L. Pharmazie. 2000;55:956.11189878

27. Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida Y. Aculeoside B, a new bisdesmosidic spirostanol saponin from the underground parts of Ruscus aculeatusJ Nat Prod. 1998;61:1279-1282.9784168

28. Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida Y. New steroidal constituents of the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells. Chem Pharm Bull. 1998;46:298-303.9501465

29. Tarayre JP, Lauressergues H. The anti-edematous effect of an association of proteolytic enzymes, flavonoids, sterolic heteroside of Ruscus aculeatus and ascorbic acid [in French]. Ann Pharm Fr. 1979;37:191-198.396842

30. Blumenthal M, ed. The Complete German Commission E Monographs. Austin, TX: American Botanical Council; 1998.

31. Vanscheidt W, Jost V, Wolna P, et al. Efficacy and safety of a Butcher’s broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency. Arzneimittelforschung. 2002;52(4):243-50.12040966

32. Cappelli R, Nicora M, Di Perri T. Use of extract of Ruscus aculeatus in venous disease in the lower limbs. Drugs Exp Clin Res. 1988;14(4):277-83.3048951

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Butcher’s Broom (Ruscus aculeatus)
Butcher’s BroomTinctures-Liquid Herbal Extracts & Benefits

European herbalists have used Ruscus aculeatus for centuries to alleviate constipation and excess water retention. Ruscus aculeatus herbal extract may ease the swelling and pain of arthritis and rheumatism, and it works very well for people who are on their feet all day. It has been used in the treatment of varicose veins, spider veins, sores, hemorrhoids, thrombophlebitis, chilblains or swelling brought on by excess water and poor circulation and even blood clots in the legs. Because it encourages the flow of urine, it is useful for combating bladder and urinary tract infections and is also thought to enhance the health of the kidneys and bladder. Though it is not that common in the U.S., European hospitals use Ruscus aculeatus to prevent blood clots after surgery. The herb is said to have cleansing properties, particularly within the blood vessels, and maintain healthy blood viscosity and cholesterol levels. Scientists are investigating Ruscus aculeatus tincture for the treatment of orthostatic hypotension (a drop in blood pressure after standing or lying down). Ruscus aculeatus is said to enhance the blood flow to the legs, hands, and brain. There are reports that Ruscus aculeatus is also a mood enhancer, providing a calming hormonal effect on teenagers during puberty and lessening the severity of mood swings. One of the other popular benefits of Butcher’s Broom is that it can correct system imbalances that inhibit proper function of the bowels. This herbal remedy can correct constipation in a short period of time.

Ruscus aculeatus is thought to help orthostatic hypotension (a drop in blood pressure upon rising from a sitting position that causes dizziness and fainting) and is also well-known for its ability to treat Meniere’s disease and vertigo. Chronic orthostatic hypotension can be a severely debilitating disease in the elderly, people with diabetes, chronic fatigue syndrome (CFS), Parkinson’s disease, scrofulous growths and in people who take medications that affect the autonomic nervous system.

In clinical trials, Ruscus aculeatus was shown to reduce swelling after radiation treatment in the upper arm. It is also thought to ease swollen lymph glands caused by syphilis and may alleviate the pain and the swelling in cases of carpal tunnel of the wrist, caused by repetitive motion. Butcher’s Broom tincture can also increase the blood flow to the brain, legs, feet, and hands. Research suggests that both orally and topically, Ruscus aculeatus extract can help to reduce the venous insufficiency related pain, cramps, heaviness, itching, and swelling in the legs and is reported to treat varicose veins and thrombophlebitis. By increasing circulation of the blood, Butcher’s Broom may be of benefit in the treatment of disorders, such as Raynaud’s disease or Buerger’s disease.

This herb is commonly used to reduce the swelling and to treat the pain and swelling associated with arthritis and rheumatism. It works particularly well for those who stand on their feet all day.

European herbal doctors have used Butcher’s Broom for centuries to alleviate excess water retention. Glycolic acid is another valuable constituent of Butcher’s Broom that has a diuretic action and promotes weight loss and can be of great help for treating obesity.

Ruscus aculeatus is ideal for eliminating fluid retention and due to its anti-inflammatory action it helps fight pain and is beneficial in the treatment of edema. It promotes bladder and kidney health and has been used in the treatment of kidney stones. With its ability to reduce water retention, it is beneficial for treating bladder infections and bladder stones as well as chilblains.

The primary constituents of Ruscus aculeatus include steroidal saponins. This herbal treatment has been used to treat chronic venous insufficiency. This is a condition in which the veins are unable to perform effectively and carry blood back to the heart. It is quite a painful condition for those who are afflicted and those who have taken this herbal remedy have been very satisfied with its healing effects. As a result of having an insufficient blood supply, blood clots can develop, another condition that Ruscus aculeatus has proven helpful in the treatment of. In Europe, a derivative of this herb is often used in hospitals to prevent the development of blood clots after surgery. Butcher’s Broom is an anti-inflammatory that reduces blood vessel fragility and permeability and may be helpful when taken before and after surgery to prevent or minimize post-operative thrombosis or blood clots.

It has also been found to be effective as a natural treatment for atherosclerosis (hardening of the arteries), another dangerous disease of the heart that is caused by plaque building up in the walls of the arteries preventing proper amounts of blood flow through them. In cases where this herb has been used, the condition is actually reversed and in this way, patients do not require open heart surgery to correct blockages.

Ruscus aculeatus may be a beneficial treatment for swollen lymph glands. The anti-inflammatory effects can help to treat lymphedema, a condition that prevents normal drainage of fluid in lymph nodes causing swelling to the extremities. It also acts to stimulate lymphatic flow, as noted by Memorial Sloan-Kettering Cancer Center and was studied to on women who developed lymphedema after breast cancer surgery. In that study, it was found to substantially reduce the swelling in the arms.

It was approved by the German Commission E guidelines as an herbal treatment for hemorrhoids and herbalists have used Ruscus aculeatus for treating painful hemorrhoids for years since discovering that it tightens the dilated blood vessels that form hemorrhoids. It is believed to be particularly effective for easing the burning and itching sensations accompanying inflamed hemorrhoids. and is also beneficial for relieving constipation, so it will definitely take away the strain that can occur in bowel movements. Not being forced to strain will lessen the swelling of the veins which is the number one cause of pain for those who are afflicted.

For maximum effectiveness of Butcher’s Broom liquid tinctures and liquid extracts, vitamin C should be taken every day, as well, since vitamin C can increase the potency against hemorrhoids and lymphedema. It is frequently combined with Witch Hazel in an ointment that can be locally applied to the anus area to bring relief of the pain that is caused by hemorrhoids.

Ruscus aculeatus tincture may be a useful treatment and prevent wet macular degeneration or any other forms of the condition. It is believed to promote blood vessel health and, therefore, may help prevent leaking blood vessels under the macula.

This herb contains rutin and other and other flavonoids that increase blood flow to the brain, as well. There are those that testify Butcher’s Broom extracts can help with mild depression, anxiety, mood swings and even the onset of Alzheimer’s disease.

Ruscus aculeatus tinctures may also clear the chest from phlegm, thus relieving difficult breathing. It has been reported to work effectively, when combined with green or black tea, to improve inhalation and exhalation.

Butcher’s Broom is also an herbal remedy that has been prescribed by health care practitioners to help treat gangrene. Scientists have discovered that sparteine, one of the main components of Ruscus aculeatus, inhibits the proteins in snake venom and is a potent treatment for detoxification of some snake bites.

Ingredients:  Ruscus aculeatus, Structured Water, 96% Alcohol.

Non-Alcohol: Ruscus aculeatus, Structured Water, and Vegetable Glycerin

All of our ingredients are Certified Organic, Kosher, or Responsibly Wildcrafted. No genetically modified organisms (GMO’s) are involved. All other products that are distributed by us meet our high-quality standards.

Instructions: Use 10-20 drops in juice or water, under the tongue or as desired. May be taken 2-4 times daily, 15 minutes before eating. Shake well. Store in cool dark place. Keep out of reach of children.

Contraindications:  Ruscus aculeatus Herbal Supplement is most effective when taken with vitamin C. Large amounts of Ruscus aculeatus (many times the recommended dosage) should not be taken, as it may cause vomiting, purging, low blood pressure and toxicity. Butcher’s Broom should not be taken with high blood pressure medications nor with medications for benign prostatic hypertrophy (BPH) or MAO inhibitors. It is recommended that this herb is used under the supervision of a healthcare provider.

Disclaimer:  The information presented herein by Herbal Alchemy is intended for educational purposes only. These statements have not been evaluated by the FDA and are not intended to diagnose, cure, treat or prevent disease. Individual results may vary, and before using any supplements, it is always advisable to consult with your own healthcare provider.

Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB.

Huang YL, Kou JP, Ma L, Song JX, Yu BY.

 Abstract

Ruscogenin (RUS), first isolated from Ruscus aculeatus, also a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been found to exert significant anti-inflammatory and anti-thrombotic activities. Our previous studies suggested that ruscogenin remarkably inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner. Yet the underlying mechanisms remain unclear. In this study, the in vivo effects of ruscogenin on leukocyte migration and celiac prostaglandin E(2) (PGE(2)) level induced by zymosan A were studied in mice. Furthermore, the effects of ruscogenin on TNF-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression and nuclear factor-kappaB (NF-kappaB) activation were also investigated under consideration of their key roles in leukocyte recruitment. The results showed that ruscogenin significantly suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, while it had no obvious effect on PGE(2) content in peritoneal exudant. Ruscogenin also inhibited TNF-alpha-induced over expression of ICAM-1 both at the mRNA and protein levels and suppressed NF-kappaB activation considerably by decreasing NF-kappaB p65 translocation and DNA binding activity. These findings provide some new insights that may explain the possible molecular mechanism of ruscogenin and Radix Ophiopogon japonicus for the inhibition of endothelial responses to cytokines during inflammatory and vascular disorders.












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