Komorač (Foeniculum vulgare L.)

Komorač (Foeniculum vulgare L.)

MATIČNA TINKTURA DOSTUPNA, TEKST U PRIPREMI

BILJNI PREPARATI KOMORAČA:

TINKTURA – KOMORAČ HSS I

MATIČNA TINKTURA – KOMORAČ TM, HIDROETANOLNI TEČNI EKSTRAKT PLODA

Tinctura Foeniculi  e fructi 1:5 Ph.Eur  

Foeniculi fructi extractum ethanolicum liquidum

BILJNI PREPARATI KOMORAČA:

TINKTURA – KOMORAČ HSS I

MATIČNA TINKTURA – KOMORAČ TM, HIDROETANOLNI TEČNI EKSTRAKT PLODA

Tinctura Foeniculi  e fructi 1:5 Ph.Eur  

Foeniculi fructi extractum ethanolicum liquidum

 (amari et dulcis)

Preparati su namenjeni kod respiratornih i gastrointestinalnih tegoba, ekspektorans kod prehlade sa produktivnim kašljem, simptomatski kod spastičkih gastrointestinalnih tegoba praćenih nadimanjem i gasovima, simptomatska terapija kod spazama vezanih za menstrualni ciklus..

 

ATC: antiseptik,
ekspektorans (sekretolitik i sekretomotorik)
karminativ,
spazmolitik,
stomahik,

anetol, Fenhon, Estragol

London, 6 August 2007
Doc. Ref. EMEA/HMPC/137428/2006 Corr

U skladu sa:

Eu. Ph. 5.0, od 2005. monografijom: Fennel (0824/ 0825) Foeniculum vulgare L., (Ph Eur monograph 0824: Foeniculi amari fructus; 0825: Foeniculi dulcis fructus),

EMA/HMPC/137428/2006 od 06 avgusta 2007, Committee on Herbal Medicinal Products (HMPC): Community herbal monograph on Foeniculum vulgare var. vulgare, fructus

EMA 07.07.2015.: EMA/HMPC/137426/2006, Committee on Herbal Medicinal Products (HMPC) od 21 februara 2008:  Assessment report on Foeniculum vulgare var. vulgare, fructus

Pharmacopée française 1989: Foeniculum vulgare ad praeparationes homoeopathicas (Foeniculum vulgare pour préparations homéopathiques)

 

Biljni preparati u tečnom obliku (nerazblaženi ili razblaženi) za oralnu i lokalnu upotrebu.

Sastav:

a) tečni ekstrakt (DER 1:5), ekstrakcioni rastvarač etanol 65% (v/v),

b) tečni ekstrakt (DER 1:10), ekstrakcioni rastvarač etanol 65%(v/v).

Foeniculum vulgare, sadrži vvv *(424) istraženih hemijskih jedinjenja koja ispoljavaju vvv *(842) dejstava (*u zagradi su podaci ažurirani juna 2016).

Sadržaj:

a) minimalno 0,0dd% m/m (MF: CddHddNOdd, MW: 2dd,40118 g/mol−1),

b) u većoj koncentraciji sadrži PETROSELINICACID Estragole

c) više od svih biljaka sadrži Anethole  Fenchone

d) plod sadrži do 89,2% vode.

 

Indikacije:

Biljni preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva.

Upotreba kod respiratornih, gastrointestinalnih i kožnih tegoba, regulisanja prekomerne težine: kao ekspektorans kod prehlade praćene produktivnim kašljem, za lakše iskašljavanje i smirivanje upale, kao i za otklanjanje tegoba organa za varenje u vidu grčeva.

(Dr. James Duke)  u Handbook of Medicinal Herbs, 2nd Ed. (2002). CRC Press, navodi sledeće:

 

Action, Medical Uses, and Dosage.—Carminative, stimulant, galactagogue, diuretic, and diaphoretic. Used in flatulent colic, and as a corrigent of unpleasant medicines. May be used in amenorrhoea and in suppressed lactation.

Fennel is a wonderful herb that helps alleviate tummy upset, colic, reflux, indigestion and heartburn, aids bowel movements, and prevents any associated cramping or griping. It is also a fantastic herb used to increase milk production in breastfeeding mothers.
For babies and children: Helps soothe colic in babies (mom takes herb and passes it to her baby through breastmilk.) For futher information on colic, see the article Gas, Colic and other Digestive Issues in Baby (Premium Article, All Access Membership required) as well as the Children’s Dosage Guidelines (free for public viewing). Many clients report that this product also helps to gently alleviate constipation in their babies. This is one of the main ingredients of Tea and Tincture. Note: may increase breastmilk production in some individuals.

Menopause activities for Foeniculum vulgare

Foeniculum vulgare MILLER – Apiaceae

Activity ( po broju akltivnih biohemijskih jedinjenja)
pesticide, Cancer-preventive, antibacterial, antioxidant, fungicide, antiinflammatory, flavor, antispasmodic, antiseptic, antitumor, allergenic, antimutagenic, perfumery, insectifuge, irritant, antiviral, sedative,
antiradicular, hypocholesterolemic, aldose-reductase-Inhibitor, analgesic 20, hypotensive, hepatoprotective, antiulcer, choleretic, diuretic, calcium-antagonist, antifeedant, herbicide, vasodilator, antiaggregant, nematicide, antitumor-promoter, antidiabetic, candidicide, antihistaminic, hypoglycemic, carcinogenic, expectorant, activity, antiherpetic, expectorant, antistaphylococcic antihepatotoxic, apoptotic, cardioprotective anticancer, antiatherosclerotic, chemopreventive, antiallergic, antidepressant, mutagenic, Immunostimulant, antiarthritic, cytotoxic 10, antiacetylcholinesterase, immunomodulator, antiacne … ukupno 424 jedinjenja.
Data National Agricultural Library

 

Fennel seed: one of nine Anglo-Saxon sacred herbs for its conventional health benefits.

 

u većoj količini sadrži PETROSELINIC-ACID, ESTRAGOLE, OLEIC-ACID, ANETHOLE i TRANS-ANETHOLE (najviše posle Pimpinella anisum), ALPHA-PINENE, POTASSIUM, GLUTAMIC-ACID, ASPARTIC-ACID, GAMMA-TERPINENE,

više od svih biljaka sadrži Fenchone,

Activities: 842 Chemicals w/Activities: 325  All Chemicals: 424

 

Reference:

Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press,

USDA’s Ag Handbook 8 and sequelae,

CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses,

List, P.H. and Horhammer, L., Hager’s Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.

 

Data by National Agricultural Library

 

 

Monografija nemačke E komisije (Commission E Monographs), terapijski vodič za biljne lekove, preporučuje Foeniculum vulgare za tretman

 

Doziranje i način primene:

2 mL (80 kapi) podeljeno u 2 do 4 doze.

Biljni preparat KOMORAČ HSS I TM:

pojedinačna doza: 0,5 – 1,0 mL,

preporučena dnevna doza (PDD): 2 mL.

Oralna (sat vremena pre obroka) i lokalna primena.

Upotreba na koži: aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja.

Ne prekoračivati preporučene doze.

Napraviti pauzu posle 4 nedelje neprekidne upotrebe (oralna upotreba).

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze.

 

Kontraindikacije: 

preosetljivost na aktivne supstance,

preosetljivost na biljke porodice (genus Foeniculum, family Apiaceae (Umbelliferae)).

Ne preporučuju se primena kod dece i adolescenata mlađih od 18 godina (zbog estragola), apsolutna kontraindikacija kod dece ispod 4 godine.

 

Čuvanje:

na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju,  u dobro zatvorenoj originalnoj ambalaži.

 

Rok upotrebe:

5 godina, posle prvog otvaranja 6 meseci. 

 

Pakovanje:

50 mL i 100 mL, farmaceutske braon bočice standarno, 250 mL, 500 mL, 1000 mL i 5000 mL na zahtev.

 

Nutritivne informacije:

KOMORAČ HSS I TM:

energetska vrednost u 100 mL: 1504 kJ/ 360 kcal,

u preporučenoj dnevnoj dozi (PDD) 2  mL: 30 kJ/ 7,2 kcal,

suve materije (DR) više od 1,4% (Fr. Ph.), 1,5% (HAB).

 

Bez konzervanasa, proteina, masti i ugljenih hidrata.

 

KOMORAČ HSS I TM  su rukom rađeni proizvodi. 

Analizu na teške metale, pesticide i mikrobiološku ispravnost preparata broj 4603120601 od 29.03.2016. godine izvršila ANAHEM LABORATORIJA BEOGRAD, u sklopu preparata RESPIRO 30.

CENOVNIK 

HSS 750 RSD 50 mL, 1500 RSD 100 mL, TINKTURA 1:5,

TM 600 RSD 50 mL, 1200 RSD 100 mL, MATIČNA TINKTURA 1:10.

http://www.biljni-preparati.com/preparati/komorac-foeniculum-vulgare-l/

Upotreba komorača (Foeniculum vulgaree L.) sa referencama

X X X X X 

Data by National Agricultural Library.

Fennel (Foeniculum vulgare)

Synonyms / Common Names / Related Terms

Adas, adas pedas, anason dulce, aneth doux, anis, Anethum foeniculum, Anthemis cotula (dog fennel), Apaiaceae (parsley family), aptechnyj ukrop, apteegitilliseemne, badesopu, badishep, bitter fennel, carosella, cay thi la, common fennel, edeskomeny, fenchel, fenheli parastie, fenhelis, fenicol, fenikel, fenkel, fenkhel, fenkoli, fenkolo, fennel honey syrup, fennel oil, fenneru, fennika, fennikel, fenouil, fenoun, fenykl, ferula communis (giant fennel), finocchio, finokio, florence fennel, Foeniculi antheroleumFoeniculum capillaceum, Foeniculum officinale, Foeniculum vulgare, Fructus foeniculi, funcho, garden fennel, guamoori, haras, harilik apteegitill, hinojo, hoehyang, hoehyang-pul, hoi huong, hui xiang, jinten manis, kama, koper wloski, komorac, koper, koromac, large cummin, large fennel, lus an t’saiodh, madhurika, maduru, marac, maratho, mehul, mellet karee, merula obisnuita, mieloi, miur belar, molura, morach, moti saunf, mouri, paciolis, pak chi duanha, pan mohuri, paprastasis pankolis, pedda jilakarra, pennel, perunjiragam, phak si, phong karee, phytoestrogen, razianaj, razianeh, razyana, rezene, samit, samong-saba, saunf, shamaar, shamar, shamari, shamraa, shatpushpa, shoap, shoumar, shumar, siu wuih heung, sladki komarcek, sladkij ukrop, so-hoehyang, sohikirai, sombu, sonf, sopu, spice of the angels, sulpha, sweet cumin, sweet fennel, thian-klaep, tian hi xiang, tieu hoi huong, tihm wuih heung, uikyo, ukrop sladki, Umbilliferae (parsley family), venkel, wariari, wild fennel, wuih heung, xiao hui xiang, yira.

NOTE: Some languages do not differentiate between anise and fennel.

SADRŽI U VEČOJ KOLIČINI SELEN

Mechanism of Action

Pharmacology:

  • Constituents: The major constituent of fennel oil is anethole. Other constituents include alpha pinene, beta myrcene, beta pinene, bitter fenchone, camphene, estragole (methyl-chavicol), fenchone, limonene, p-cymen, and safrole.
  • Fennel is a rich source of beta-carotene and vitamin C4, as well as calcium, magnesium, iron, and lesser amounts of other metal cations3.
  • Anti-carcinogenic and anti-inflammatory effects: Anethole’s effects may be mediated by modulation of tumor necrosis factor (TNF) – induced cellular responses. Anethole may interfere with TNF signaling and lead to the activation of NF-kappaB, AP-1, JNK, MEK, and apoptosis. Anethole may suppress NF-kappaB-dependent gene expression induced by TNF. NF-kappaB controls the expression of some genes involved in carcinogenesis and inflammation.5
  • Estragole is a natural constituent of a number of plants including fennel. Estragole is a procarinogen but has minimal carcinogenic risk. To reach full toxicity, estragole must be activated by liver enzymes. Fortunately, other liver enzymes inactivate it, limiting liver damage.6,7,8
  • Anticoagulant effectsFerrula communis, giant fennel, contains coumarin derivatives that competitively inhibit vitamin K and interfere with blood clotting. In animal studies, internal bleeding and death resulted after ingestion over an extended period of time.2
  • Anti-diabetic effects: Essential oil of fennel seed has been reported to stimulate pancreatic alpha-cells and insulin secretion.9
  • Antispasmodic effects: Fennel seed increases gastrointestinal motility and acts as an antispasmodic at high doses. Fennel extracts produce a reduction in acetylcholine-induced contraction and decreases maximum possible contractility.11
  • Gastric acid secretion properties: Fennel in a concentration of 10% weight/volume increased gastric acid secretion in rats from 0.12mL (basal level) to 0.42mL. The exact mechanism of increasing gastric acid secretion is unknown.
  • Muscle relaxant effects: Fennel oil has demonstrated an increase in resting force of guinea pig tracheal smooth muscle. Anethole may be responsible for the positive inotropic effect.12 In another animal study, sweet fennel oil inhibited acetylcholine-induced contractions of ileal and bladder smooth muscles. The mechanism of action is thought to be due to an inhibition of calcium release from intracellular stores and binding to calcium-binding proteins by the constituents in the fennel oil.13
  • Mucociliary effects: Based on secondary sources, aqueous fennel extracts increased mucociliary activity of the ciliary epithelium in the respiratory tract in frogs.1

Pharmacodynamics/Kinetics:

  • Insufficient available evidence.

 

References

  1. Blumenthal, M. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. 1998;
  2. Shlosberg, A. and Egyed, M. N. Examples of poisonous plants in Israel of importance to animals and man. Arch Toxicol.Suppl 1983;6:194-196. 6578721
  3. Zhu, M., Wong, P. Y., and Li, R. C. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm.Pharmacol 1999;51(12):1391-1396. 10678493
  4. Brinker, F. Herb Contraindications and Drug Interactions. 1998;2nd
  5. Chainy, G. B., Manna, S. K., Chaturvedi, M. M., and Aggarwal, B. B. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene 6-8-2000;19(25):2943-2950. 10871845
  6. De Vincenzi, M., Silano, M., Maialetti, F., and Scazzocchio, B. Constituents of aromatic plants: II. Estragole. Fitoterapia 2000;71(6):725-729. 11077188
  7. Iten, F. and Saller, R. [Fennel tea: risk assessment of the phytogenic monosubstance estragole in comparison to the natural multicomponent mixture]. Forsch Komplementarmed Klass Naturheilkd 2004;11(2):104-108. 15138375
  8. Iyer, L. V., Ho, M. N., Shinn, W. M., Bradford, W. W., Tanga, M. J., Nath, S. S., and Green, C. E. Glucuronidation of 1′-hydroxyestragole (1′-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. Toxicol.Sci 2003;73(1):36-43. 12657745
  9. Farag, R, Abu-Raiia, S, and Abdel-Moein, N. The essential oils of coriander, common dill, and bitter fennel and their effects on diabetic rats. Bull Fac of Agric, Univ of Cairo 1992;43(1):31-44.
  10. Weizman, Z, Alkrinawi, S, and Goldfarb, D. Efficacy of herbal tea preparation in infantile colic. J Pediatr 1993;122(650):652.
  11. Vasudevan, K., Vembar, S., Veeraraghavan, K., and Haranath, P. S. Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats. Indian J Gastroenterol 2000;19(2):53-56. 10812814
  12. Reiter, M. and Brandt, W. Relaxant effects on tracheal and ileal smooth muscles of the guinea pig. Arzneimittelforschung 1985;35(1A):408-414. 4039178
  13. Saleh, M, Hashem, F, and Grace, M. Volatile oil of Egyptian sween fennel (Foeniculum vulgare, var. dulce. Alef.)

 

Izvor: www.sigmaaldrich.com












Pakovanje mL/ g:
 10 20 30 50 100 250 500 1000

Količina:
1 2 3 više 

 

vrh