Mlečika Epilobium angustifolium/ parviflorum (Onagraceae)

Mlečika Epilobium angustifolium/ parviflorum (Onagraceae)

Mlečika (Epilobium parviflorum/anguistifolium L.

BILJNI PREPARATI MLEČIKE: TINKTURA I MATIČNA TINKTURA (MLEČIKA HSS i TM)

Tinctura Epilobium parviflorum/anguistifolium L. (Ph. Eur. DER 1:5)

Epilobii parviflorum/anguistifolium recentis extractum ethanolicum liquidum

Preparati mlečike su namenjeni kod problema sa benignom hiperplazijom prostate 

Tradicionalno, koristi se za olakšanje mokrenja i tegoba usled benigne hiperplazije prostate, pa je najviše korise muškarci. Čaj se koristi i za ublažavanje gastro-intestinalnih tegoba – osećaja pečenja u želucu, enteritisa, dijareje, kolitisa i iritabilnog kolona. U narodnoj medicini se koristi i kod kožnih problema, kod ekcema, kao antiseptik kod gljivičnih infekcija i za ubrazanje zarastanja rana.

Prema zvaničnim indikacijama navedenim u monografiji Evropske Medicinske Agencije, na osnovu dugotrajnih dokazanih iskustava o efikasnosti upotrebe, upotreba sitnocvetne vrbovice preporučuje se muškarcima: cilju ublažavanje tegoba kod benigne hiperplazije prostate, čaj se može koristiti u dužem vrmenaskom periodu.

Ukoliko se sitnocvetna vrbovica koristi za ublažavanje gastro-intestinalnih tegoba, usled nedostatka podataka o bezbednosti, savetuje se oprez tokom trudnoće, dojenja i kod dece mlađe od 12 godina.

Pored sitnocvete vrbovke i drugi vidovi vrbovki imaju lekovito dejstvo kao sto su:
Epilobium roseum – roze crvena vrbovka
Epilobium montanum – planinska vrbovka 2
Epilobium obscurum – tamnozelena vrbovka
Epilobium lanceolatum – lancetovidna vrbovka
Epilobium collinum – brezuljkasta vrbovka
Epilobium palustre – blatna vrbovka
Epilobium fleischer – sljunkasta vrbovka
Epilobium anagallidifolium – alpska vrbovka
Vrste koje se ne prporucuju za upotrebu su:
Epilobium hirsutum 2
Epilobium angustifolium

BILJNI PREPARATI MLEČIKE: TINKTURA I MATIČNA TINKTURA (MLEČIKA HSS i TM)

ATC: A09AX – Erscheinungsdatum Bundesanzeiger: 18.9.1986., Heftnummer: 173., ATC-Code: A09AX.; Monographie

U skladu sa Eu. Ph. 8  monografijom: 

EMA/HMPC/712511/2014 Committee on Herbal Medicinal Products (HMPC) od 24 November 2015: Committee on Herbal Medicinal Products (HMPC)
European Union herbal monograph on Epilobium angustifolium L. and/or Epilobium parviflorum Schreb., herba, Final

EMA/HMPC/712510/2014 Committee on Herbal Medicinal Products (HMPC) od 24 November 2015: Assessment report on Epilobium angustifolium L. and/or Epilobium parviflorum Schreb., herba, Final

Deutsches Homöopathisches Arzneibuch – HAB:

Epilobium ad praeparationes homoeopathicas (Epilobium angustifolium L. and/or Epilobium parviflorum Schreb., pour préparations homéopathiques), method 3a,

Pharmacopée française 2002: Epilobium parviflorum/anguistifolium L.)ad praeparationes homoeopathicas (Epilobium parviflorum/anguistifolium L.) for homeopathic preparations)

HPUS 78: Epilobium angustifolium L. and/or Epilobium parviflorum Schreb.,hom. HPUS78. 

 a) Epilobium angustifolium L. and/or Epilobium parviflorum Schreb., (smallflower hairy willowherb fresh plant, above ground parts ).

 

Biljni preparati u tečnom obliku (nerazblaženi ili razblaženi) za oralnu i lokalnu upotrebu.

 

Sastav: a) tečni ekstrakt (DER 1:2), ekstrakcioni rastvarač etanol 65% (v/v),

Epilobium angustifolium L. and/or Epilobium parviflorum Schreb.,sadrži preko xxx *(xxx) istraženih hemijskih jedinjenja koja ispoljavaju xxx *(xxx) dejstava.

 

Sadržaj:

a) minimalno 0,15% m/m tanina izraženog kao pirogalol (pyrogallol) (MF: C6H6O3ili C6H3(OH)3, MW: 126,11004 g/mol−1),

b) u većoj koncentraciji sadrži flavonoide, tanine, triterpene, fitosterole

c) više od svih biljaka sadrži

d) 

 

Indikacije: biljni preparati su namenjeni poboljšanju opšteg stanja organizma kroz razna naučno dokazana dejstva.

Upotreba za ublažavanje simptoma u donjem delu urinarnog trakta, koji su povezani sa benignom hiperplazijom prostate.

For symptomatic treatment of mild micturition disorders related to benign prostatic hyperplasia, irritable bladder. Relief of symptoms of benign prostatic hypertrophy or inflammation such as nocturia, frequent daytime micturition, lack of complete emptying.

 

Dr. Džems Djuk (Dr. James Duke) u Handbook of Medicinal Herbs, 2nd Ed. (2002). CRC Press, navodi sledeće:

 – ima jako dejstvo kod: 

– delotvoran kod:

– u narodnoj medicini kod:

– spoljašnja primena kod:

– upotrebljava se kao:

 

Monografija nemačke E komisije (Commission E Monographs), terapijski vodič za biljne lekove, preporučuje Epilobium za tretman benigne hiperplazije prostate, kod tegoba sa mokrenjem.

 

Doziranje i način primene: 2 mL (80 kapi) podeljeno u 2 do 4 doze.

Biljni preparati MLEČIKA HSS i TM: pojedinačna doza: 0,5-1 mL, preporučena dnevna doza (PDD): 2 mL. Oralna (15 minuta pre obroka) i lokalna primena. Upotreba na koži: aplicirati na obolelo mesto u tankom sloju ili obliku impregniranog zavoja. Napraviti pauzu posle 4 nedelje neprekidne upotrebe.

Po preporukama, preparat postiže najbolje efekte pri upotrebi od 8 do 12 nedelja, duža upotreba je bezbedna uz pauze od po nedelju dana.

Kontraindikacije: preosetljivost na aktivne supstance, preosetljivost na biljke porodice (genus Epilobium, family Onagraceae), trudnoća.

Interakcije: ne postoje adekvatni podaci o mogućim interakcijama; pri upotrebi u preporučenim dnevnim dozama nema interakcija i neželjenih efekata.

Čuvanje: na tamnom, suvom i hladnom mestu do 20˚C, van domašaja dece i izlaganja EM zračenju,  u dobro zatvorenoj originalnoj ambalaži.

Rok upotrebe: 5 godina, posle prvog otvaranja 6 meseci.

Pakovanje: 50 mL i 100 mL, standarne farmaceutske braon bočice; 250 mL, 500 mL, 1L i 5 L na zahtev.

Nutritivne informacije: MLEČIKA HSS i TM:

energetska vrednost u 100 mL:  1172 kJ/ 280 kcal,

u preporučenoj dnevnoj dozi (PDD) 2 mL: 23,45kJ/ 5,6 kcal,

suve materije (DR) više od 1,5% (Ph. Fr.), RD 0,900 – 0,930.

Bez konzervanasa, proteina, masti i ugljenih hidrata.

MLEČIKA HSS i TM su rukom rađeni proizvodi. 

 

CENOVNIK

MATIČNA TINKTURA MALA MLEČIKA/ MLEČIKA

TM  50 mL – 600,00 RSD (5 e); 100 mL – 1200,00 RSD (10 e), 

Upotreba mlečike (Epilobium spp.) sa referencama.

E Epilobium angustifolium (Onagraceae)  Common nameYakiotu

upotreba reference
antiflogistik
adstrigent Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
čaj Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
tonik Steinmetz, E.F. 1957. codex Vegetabilis. Published by the author, Amsterdam.
Tu
povrede

Data by National Agricultural Library

CERES Epilobium parviflorum Urtinktur 

Allgemeine Informationen zu CERES Epilobium parviflorum Urtinktur
Epilobium parviflorum Ø
Weidenröschen-Urtinktur
Verwendete Pflanzenteile: Frisches Kraut zu beginnender Blüte

Herstellvorschrift: HAB, § 2a

Einnahmeempfehlung für Ceres Heilmittel

Beachten Sie die tiefe Dosierung
Ceres-Arzneimittel werden in sehr tiefer Dosierung (in der Regel 1 bis 3 x täglich 2-5 Tropfen) ein­genommen. Holen Sie bei Bedarf medizinischen Rat ein.

Verweilen Sie einige Augenblicke beim Aroma
Nehmen Sie das Aroma durch Nase und Gaumen bewusst auf. Das Aroma ist von grosser Bedeutung und verstärkt die lebensfördernde und harmonisierende Wirkung. Am besten entfalten sich die Wirkkräfte, wenn die Tropfen in etwas Wasser ge­geben, eine Weile im Mund behalten werden. Sie können die Tropfen aber auch direkt auf die Zunge geben und einspeicheln. Dies wird vor allem im Akutfall empfohlen.

Erspüren Sie das Wesen der Arznei
Treten Sie mit dem Wesen der Heilpflanze auf Ihre ganz persönliche Weise in einen inneren Dialog. Häufigkeit und Dauer der Einnahme sollen innerlich erspürt werden. Es ist die Sprache des Körpers, die Ihnen signalisiert, ob das Mittel gebraucht wird oder nicht. Genies­sen und kosten Sie die Aufnahme der Tropfen, wie fein zubereitete Nahrung.

Nehmen Sie geistige, seelische und körperliche Signale wahr
Beobachten Sie sich: Verschlimmern sich die Symptome oder treten neue hinzu, kann das eine Folge zu hoher Dosierung sein. Legen Sie in diesem Fall eine Pause von einigen Tagen ein und fahren Sie danach mit tieferer Dosierung fort. Holen Sie bei anhaltenden Symp­tomen medizinischen Rat ein.

Zeitlicher Mindestabstand mehrerer Urtinkturen
Werden mehrere Ceres Heilmittel parallell eingenommen, sollte ein zeitlicher Abstand von mindestens 15 Minuten eingehalten werden. Geniessen Sie die Auf- und Annahme der heilenden Impulse bewusst.

Informieren Sie sich
Bisherige Erfahrungen zeigen, dass Ceres-Arzneimittel problemlos mit schulmedizinischen, homöopathischen und komplementär­medi­zinischen Heilmitteln kombiniert werden können. Holen Sie trotzdem medizinischen Rat ein, wenn Sie an Krankheiten leiden, Allergien haben oder weitere – auch selbstgekaufte – Arzneimittel ein­nehmen.
Zusammensetzung von CERES Epilobium parviflorum Urtinktur

Antimicrobial activity of Epilobium spp. extracts.

The antimicrobial activity of the Epilobium angustifolium, E. hirsutum, E. palustre, E. tetragonum and E. rosmarinifolium ethanolic extracts was studied in vitro on Gram-positive and Gram-negative bacteria, yeasts and fungi. The cytotoxicity of the extracts was also evaluated using the Artemia salina test. All the extracts showed antimicrobial activity in a range of concentrations between 10 and 650 microgml of dry extract. E. angustifolium and E. rosmarinifolium had the most broad spectrum of action inhibiting bacteria, yeasts and fungi. The extracts were devoid of toxicity on Artemia salina within the range of antimicrobial concentrations, suggesting that the action is selective on microorganisms.

 

X X X X X

What do we know about phytotherapy of benign prostatic hyperplasia? 

Benign prostatic hyperplasia (BPH) is one of the most common urological diseases in aging men. Because of its long latency, BPH is a good target for prevention. The aim of the study has been to review the various options of treatment, currently available, in the field of phytotherapy. Watchful waiting, pharmacological therapy, and surgery are also helpful, depending on the severity of the disease. Although drug therapy (alpha1-blockers, 5alpha-reductase inhibitors) and surgery (prostatectomy, transurethral resection, etc.) seem to be most effective for patients with moderate-severe BPH, herbal medicines (i.e., Serenoa repens, Pygeum africanum, Urtica dioica) are also commonly used in patients with mild-moderate symptoms. On the basis of preclinical studies several mechanisms of action have been postulated, including 5alpha-reductase inhibition, alpha-adrenergic antagonism, dihydrotestosterone and estrogen receptor inhibition. Randomized clinical trials indicate significant efficacy in improving urinary symptoms and mild adverse effects for some phytotherapeutic agents, while further clinical evidence is needed for others (e.g., Epilobium spp., Secale cereale, Roystonea regia). Healthcare professionals should be constantly informed about BPH phytotherapy, taking into account the risk/benefit profile of the use of medicinal plants in the management of BPH.

X X X X X 

Extracts from Epilobium sp. herbs induce apoptosis in human hormone-dependent prostate cancer cells by activating the mitochondrial pathway.

OBJECTIVES:

The aim of this work was to determine the effect of standardized aqueous extracts from Epilobium angustifolium L., E. parviflorum Schreb. and E. hirsutum L. herbs on the apoptosis of hormone-dependent prostate cancer cells (LNCaP).

METHODS: The extracts were characterized using high-performance liquid chromatography-diode array detector coupled with mass spectrometry (HPLC-DAD-MS/MS). Apoptosis in the cells was analysed using Annexin V-fluorescein isothiocyanate, and mitochondrial potential, Δψm , using JC-1 by flow cytometry. Caspase-3 activity was determined by enzyme-linked immunosorbent assay.

KEY FINDINGS: Using the HPLC-DAD-MS/MS method, 38 constituents were characterized. Extracts contained significant amounts of oenothein B as well as flavonoids and phenolic acids. Exposure of LNCaP cells to the extracts (20, 50 and 70 μg/ml) resulted in a significant increase in the level apoptotic cells, from 2.86 ± 0.5% (for untreated cells) up to 86.6 ± 1.0%. All extracts significantly decreased the mitochondrial potential, Δψm , resulting in an increase in the activity of caspase-3 from 0.3 ± 0.07 ng/mg of protein (for untreated cells) up to 1.26 ± 0.32 ng/mg of protein.

CONCLUSIONS: This study demonstrated that Epilobium extracts are active against LNCaP prostate cancer cells and that their apoptotic activity is related to activation of the mitochondrial pathway. The high oenothein B content may influence the biological activity of these plant materials

X X X X X

Oenothein B’s contribution to the anti-inflammatory and antioxidant activity of Epilobium sp.

Willow herb tea or preparation are available and relatively popular in the European market, and claimed to be effective inter alia because of their anti-inflammatory activity. The present study is therefore aimed at comparing the anti-inflammatory and antioxidant activity of extracts of the three most popular Epilobium species (E. angustifolium, E. hirsutum and E. parviflorum) and at juxtaposing this activity against the dominating compounds from the following extracts: oenothein B (OeB), quercetin-3-O-glucuronide and myricetin-3-O-rhamnoside. The phytochemical analysis of the extracts has shown that OeB quantities vary between 20% and 35%, while flavonoids content does not exceed 2%. All extracts have inhibited the activity of hyaluronidase and lipoxygenase with IC₅₀ around 5 μg/ml and 25 μg/ml. The inhibition of hyaluronidase is related with the presence of OeB, a strong inhibitor of this enzyme (IC₅₀) 1.1 μM). Additionally, the extracts inhibited myeloperoxidase (MPO) release from stimulated neutrophils. OeB inhibited MPO release similarly to the anti-inflammatory drug indomethacin with IC₅₀ 7.7 μM and 15.4 μM, respectively. Tested extracts significantly reduced the production of reactive oxygen species (ROS) from f-MLP and PMA induced neutrophils with IC₅₀ 5 μg/ml and 25 μg/ml, respectively. The flavonoids content seems to exert little influence on extracts’ activity, contrary to OeB, whose high concentration explains the activity of extract obtained from Epilobium. Tested currently marketed Epilobium preparations are often wrongly assigned, but we should stress that the level of OeB in all tested herbs was high and always exceeded 2% in raw material.

X X X X X 

Antioxidant and antiinflammatory effect of Epilobium parviflorum Schreb. 

Epilobium parviflorum Schreb. (Onagraceae) is used for the treatment of benign prostatic hyperplasia (BPH), but its biological action is not entirely identified. This paper aims to report data on E. parviflorum with respect to its antioxidant and antiinflammatory effects. The aqueous acetone extract of E. parviflorum showed higher antioxidant effect in the DPPH assay than well known antioxidants and inhibited the lipid peroxidation determined by the TBA assay (IC(50) = 2.37 +/- 0.12 mg/mL). In concentrations of 0.2-15.0 microg/mL the extract possessed a protective effect, comparable to catalase (250 IU/mL), against oxidative damage, generated in fibroblast cells. In the COX inhibition assay E. parviflorum decreased the PGE(2) release, so showing inhibition of the COX-enzyme (IC(50) = 1.4 +/- 0.1 microg/mL).

XXXXXXXX

Therapeutic Potential of Polyphenols from Epilobium angustifolium (Fireweed)

Epilobium  palustre Bundesanzeiger Nr. 109 a vom 16.6.1987  Monographie BGA/BfArM (Kommission D)












Pakovanje mL/ g:
 10 20 30 50 100 250 500 1000

Količina:
1 2 3 više 

vrh